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| 1 | Anti-diabetic activity of quercetin extracted from Phyllanthus emblica L.fruit: In silico and in vivo approaches显示文摘In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin(STZ)-induced diabetic rats was examined. The isolated quercetin administered at a dose of 75 mg/kg body weight produced a maximum decrease of14.78% in blood glucose levels in the diabetic rats after 7 days of treatment. Furthermore, quercetin doses of 50 and 75 mg/kg were shown to significantly improve the profiles of triglycerides, high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein, and total cholesterol at the end of the study in STZ-induced diabetic rats. The administration of quercetin(25, 50, and 75 mg/kg body weight)daily for 28 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and urine sugar levels, with a considerable rise in plasma insulin and hemoglobin levels. Therefore, quercetin is a potential drug with antidiabetic and antihyperglycemic action mediated by changes in the levels of glucose, cholesterol, and triglycerides as indicated by in silico and in vivo studies. | Prabhu Srinivasan S.Vijayakumar Swaminathan Kothandaraman Manogar Palani | 2018 | Journal of Pharmaceutical Analysis2018，8，2： | 18 |
| 2 | Thermal properties ofpolyvinyl alcohol 显示文摘 | Vijayakiimar C T Kothandaraman H | 1983 | Thermochimica Acta1983，60，3： | 1 |
| 3 | Implementing Relationship Strategy显示文摘 | Kothandaraman Wilson | 2000 | Industrial Marketing Management2000，29，4： | 1 |
| 4 | Chemical com- position and nutritional value of para rubber seed and its products for chickens 显示文摘 | NARAHARI D KOTHANDARAMAN P | 1984 | Animal Feed Science Tech- nology1984，10，： | 1 |
| 5 | Utilization of undecorticated safflower seed meal in layer rations显示文摘 | Raj Kothandaraman | 1981 | lndian J Poultry Sci1981，16，4： | 1 |
| 6 | The future of competition value-creating networks显示文摘 | Kothandaraman Prabakar Wilson David T | 2001 | Industrial Marketing Management2001，30，4： | 1 |
| 7 | The thermal dissociation of phenol - blocked toluene diisocyanate crosslinkers 显示文摘 | H Kothandaraman A Suhhan Nasar | 1993 | Polymer1993，34，3： | 1 |
| 8 | Morphometry of the iliolumbar artery and the iliolumbar veins and their correlations with the lumbosacral trunk and the obturator nerve显示文摘 | Teli CG Kate NN Kothandaraman U | 2013 | Journal of Clinical and Diagnostic Research2013，7，3： | 1 |
| 9 | Soil phenolics and plant growth inhibition 显示文摘 | Chandramohan D Purushothaman D Kothandaraman R | 1973 | Plant Soil1973，39，： | 1 |
| 10 | The future of competition-value-creating networks显示文摘 | Kothandaraman P Wilson D T | 2001 | Industrial Marketing Management2001，，30： | 1 |
| 11 | Naturally colored lint genetic resources in National Cotton Gene Bank, their characteristics and utilization显示文摘 | SINGH V V Mohan P Kothandaraman R | 1996 | CottonImprov1996，21，2： | 1 |
| 12 | Fusidic acid-induced hyperbilirubinemia显示文摘 | Kutty KP Nath IV Kothandaraman KR | | 0，，08： | 1 |
| 13 | E2F5 sta- tus significantly improves malignancy diagnosis of epitheli- al ovarian cancer 显示文摘 | Kothandaraman N Bajic VB Brendan PN | 2010 | BMC Cancer2010，64，10： | 1 |
| 14 | Synthesis and thermal diisociation of phenol-and naphthol-blocked diisocyanates显示文摘 | KOTHANDARAMAN H NASAR A S LAKSHMI R K | 1994 | Journal of Applied Polymer Science1994，53，1： | 1 |
| 15 | The future of competition显示文摘 | Kothandaraman Prabhakar and Wilson David T | 2001 | Industrial Marketing Management2001，30，4： | 1 |
| 16 | The thermal dissociation of phenol- blocked toluene diisocyanate crosslinkers显示文摘 | KOTHANDARAMAN H SULTAN NASAR A | 1993 | Polymer1993，34，3： | 1 |
| 17 | Polymerization of methyl methacrylate and p-fluorostyrene with the ferric acetylacetonate-teiethylaluminum catalyst system 显示文摘 | Kothandaraman H Palanivelu K | 1987 | J Macromol Sci Chem1987，24，2： | 1 |
| 18 | The Future of Competition显示文摘 | Prabakar Kothandaraman David T Wilson | 2001 | Industrial Marketing Management2001，，4： | 1 |
| 19 | Studies on toluenediisocyanate blocked by benzophenone oximes显示文摘 | R Thangavel | 1993 | J Polym Sci Polym Chem1993，31，： | 1 |
| 20 | Synthesis and thermal diisocyanate of phenol-and naphthol-blocked diisocyanates显示文摘 | A Sultan Nasar R Kamal Lakshmi | 1994 | J Appl Polym Sci1994，53，： | 1 |
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