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| 1 | Pulmonary fibrosis and emphysema: Is the emphysema type associated with the pattern of fibrosis?显示文摘AIM: To investigate whether the predominant emphysema type is associated with the high resolution computed tomography(HRCT) pattern of fibrosis in combined pulmonary fibrosis and emphysema(CPFE).METHODS: Fifty-three smokers with upper lobe emphysema and lower lobe pulmonary fibrosis on- HRCT-were retrospectively evaluated. Patients were stratified into 3 groups according to the predominant type of emphysema: Centrilobular(CLE), paraseptal(PSE), CLE = PSE. Patients were also stratified into 3 other groups according to the predominant type of fibrosis on HRCT: Typical usual interstitial pneumonia(UIP), probable UIP and nonspecific interstitial pneumonia(NSIP). HRCTs were scored at 5 predetermined levels for the coarseness of fibrosis(Coarseness), extent of emphysema(emphysema), extent of interstitial lung disease(Tot Ext ILD), extent of reticular pattern not otherwise specified(Ret NOS), extent of ground glass opacity with traction bronchiectasis(extG GOBx), extent of pure ground glass opacity and extent of honeycombing. HRCT mean scores, pulmonary function tests, diffusion capacity(DLCO) and systolic pulmonary arterial pressure were compared among the groups.RESULTS: The predominant type of emphysema was strongly correlated with the predominant type of fibrosis. The centrilobular emphysema group exhibited a significantly higher extent of emphysema(P < 0.001) and a lower extent of interstitial lung disease(P < 0.002), reticular pattern not otherwise specified(P < 0.023), extent of ground glass opacity with traction bronchiectasis(P < 0.002), extent of honeycombing(P < 0.001) and coarseness of fibrosis(P < 0.001) than the paraseptal group. The NSIP group exhibited a significantly higher extent of emphysema(P < 0.05), total lung capacity(P < 0.01) and diffusion capacity(DLCO)(P < 0.05) than the typical UIP group. The typical UIP group exhibited a significantly higher extent of interstitial lung disease, extent of reticular pattern not otherwise specified, extent of ground glass opacity with traction bronchiectasis, extent of honeycombing and coarseness of fibrosis(0.039 > P > 0.000). Although the pulmonary arterial pressure was higher in typical UIP group relative to the NSIP group, the difference was not statistically significant.CONCLUSION: In CPFE patients, paraseptal emphysema is associated more with UIP-HRCT pattern and higher extent of fibrosis than centrilobular emphysema. | Anastasia Oikonomou Paraskevi Mintzopoulou Argyris Tzouvelekis Petros Zezos George Zacharis Anastasios Koutsopoulos Demosthenes Bouros Panos Prassopoulos | 2015 | World Journal of Radiology2015，7，9： | 2 |
| 2 | A microscopic traffic simulator for evaluation of dynamic traffic management systems 显示文摘 | Yang Qi Koutsopoulos H N | 1996 | Transportation Research C1996，4，3： | 1 |
| 3 | Effects of antifibrotic agents on TGF-beta1, CTGF and IFN-gamma expression in patients with idiopathic pulmonary fibrosis显示文摘 | Tzortzaki EG Antoniou KM Zervou MI Lambiri I Koutsopoulos A Tzanakis N Plataki M Maltezakis G Bouros D Siafakas NM | 2007 | Respir Med2007，101，8： | 1 |
| 4 | Integrated driving behavior modeling 显示文摘 | Toledo T Koutsopoulos H N Ben-Akiva M | 2007 | Transportation Research Part C2007，15，2： | 1 |
| 5 | Clinical outcome of patients with non-small cell lung cancer receiving front-line chem- otherapy according to EGFR and K-RAS mutation status显示文摘 | Kalikaki A Koutsopoulos A Hatzidaki D | 2010 | Lung Cancer2010，69，1： | 1 |
| 6 | Towards Disaggregate Dynamic Travel Forecasting Models显示文摘The authors argue that travel forecasting models should be dynamic and disaggregate in their representation of demand, supply, and supply-demand interactions, and propose a framework for such models. The proposed framework consists of disaggregate activity-based representation of travel choices of individual motorists on the demand side integrated with disaggregate dynamic modeling of network performance, through vehicle-based traffic simulation models on the supply side. The demand model generates individual members of the population and assigns to them socioeconomic characteristics. The generated motorists maintain these characteristics when they are loaded on the network by the supply model. In an equilibrium setting, the framework lends itself to a fixed-point formulation to represent and resolve demand-supply interactions. The paper discusses some of the remaining development challenges and presents an example of an existing travel forecasting model system that incorporates many of the proposed elements. | Moshe Ben-Akiva Jon Bottom Song Gao Haris N. Koutsopoulos Yang Wen | 2007 | Tsinghua Science and Technology2007，12，2： | 1 |
| 7 | Network State Estimation and Prediction for Real-time Transportation Management Apphcations 显示文摘 | BEN-ALIVA M BIERIARIE M KOUTSOPOULOS H N | 2001 | Networks and Spatical Economice2001，1，34： | 1 |
| 8 | Cross-layer adaptive techniques for throughput enhancement in wireless OFDM-Based networks显示文摘 | KOUTSOPOULOS I TASSIULAS L | 2006 | IEEE/ACM Transactions on Networking2006，14，5： | 1 |
| 9 | Maximum-throughput access control in wireless LANs through max-weight-inspired policies显示文摘 | Oliveira R Koutsopoulo I | | 0，，06： | 1 |
| 10 | Modeling discrete choice behavior using concepts from fuzzy set theory, approximate reasoning and neural networks显示文摘 | VYTHOULKAS P C KOUTSOPOULOS H N | 2003 | Transportation Researeh Part C2003，11，1： | 1 |
| 11 | Malignant mixed tumor of the nasal cavity显示文摘 | Chimona TS Koutsopoulos AV Malliotakis P | 2006 | Auris Nasus Laryna2006，33，1： | 1 |
| 12 | Expression of apoptotic and antiapoptotic markers in epithelial ceils in idiopathic pulmonary fibrosis 显示文摘 | Plataki M Koutsopoulos AV Darivianaki KG | 2005 | Chest2005，127，1： | 1 |
| 13 | The calcification of fibrin in vitro显示文摘 | Koutsopoulos S Dalas E | 2000 | J Crystal Growth2000，216，： | 1 |
| 14 | Nonlin- ear Kalman filtering algorithms for on-line calibration of dynam- ic traffic assignment models 显示文摘 | ANTONIOU C BEN-AKIVA M KOUTSOPOULOS H N | 2007 | IEEE Transactions on Intelligent Transportation Systems2007，8，4： | 1 |
| 15 | Slow release of molecules in self-assembling peptide nanofiber scaffold显示文摘 | Nagai Y Unsworth LD Koutsopoulos S Zhang S | 2006 | J Control Release2006，115，： | 1 |
| 16 | Altered surfactant protein-A expression in type II pneumocytes in COPD显示文摘 | Vlachaki EM Koutsopoulos AV Tzanakis N | | 0，，： | 1 |
| 17 | Simulation of ur- ban rail operations application framework 显示文摘 | Koutsopoulos Haris N Wang Zhigao | 2006 | Transporta- tion Research Record2006，，5： | 1 |
| 18 | Kinetically controlled refolding of a heat-denatured hyperthermostable protein 显示文摘 | Koutsopoulos S van der Oost J Norde W | 2007 | FEBS Journal2007，274，22： | 1 |
| 19 | Cross-layer adaptive techniques for throughput enhancement in wireless OFDM- based networks显示文摘 | Koutsopoulos I Tassiulas L | 2006 | IEEE/ACM Transactions on Networking2006，14，5： | 1 |
| 20 | High Beclin 1 expression defines a poor prognosis in endometrial adeno- carcinomas 显示文摘 | Giatromanolaki A Koukourakis MI Koutsopoulos A | 2011 | Gynecol Oneol2011，123，1： | 1 |
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