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| 1 | 关节镜下骨-髌腱-骨移植重建前十字韧带显示文摘目的关节镜下以可吸收界面螺钉固定骨-髌腱-骨(bone-patellartendon-bone,BPB)重建膝前十字韧带(ACL),并分析影响疗效的因素。方法1999年12月~2003年6月,采用关节镜下可吸收界面螺钉固定BPB移植修复ACL损伤32例,男22例,女10例;年龄20~45岁,平均32.5岁;左膝18例,右膝14例。急性损伤8例,陈旧性损伤24例。术前膝关节功能Lysholm评分平均为(52.1±5.6)分。行膝前小切口切取BPB并修整,建立骨隧道,安放胫骨侧骨块时外旋90°以适应ACL前内和后外两束的解剖结构和生理功能,采用可吸收界面螺钉固定BPB两端骨块。同时,在关节镜下处理合并损伤。术后早期行CPM功能锻炼。结果32例患者均获随访,随访6~40个月,平均32个月。采用改良Lysholm评分标准评价疗效:优24例,良7例,可1例;术后膝关节功能Lysholm评分为(98.7±3.6)分,与术前相比差异有显著性(P<0.05)。结论关节镜下可吸收界面螺钉固定BPB移植重建ACL是一种微创手术,操作简单,疗效肯定。 | 冯世庆 郭世绂 王沛 马信龙 郑永发 孙振辉 刘涛 Jeyan Krishnan | 2004 | 中华骨科杂志2004，24，3： | 22 |
| 2 | Robust stability criteria for uncertain linear systems with interval time-varying delay显示文摘This paper considers the robust delay-dependent stability problem of a class of linear uncertain system with interval time-varying delay and proposes less conservative stability criteria for computing the maximum allowable bound of the delay range. Less conservatism of the proposed stability criteria is attributed to the delay-central point method of stability analysis, wherein the delay interval is partitioned into two subintervals of equal length, and the time derivative of a candidate Lyapunov-Krasovskii functional based on delay decomposition technique is evaluated in each of these delay segments. In deriving the stability conditions in LMI framework, neither model transformations nor bounding techniques using free-weighting matrix variables are employed for dealing the cross-terms that emerge from the time derivative of the Lyapunov-Krasovskii functional; instead, they are dealt using tighter integral inequalities. The proposed analysis subsequently yields a stability condition in convex LMI framework that can be solved using standard numerical packages. For deriving robust stability conditions, two categories of system uncertainties, namely, time-varying structured and polytopic-type uncertainties, are considered. The effectiveness of the proposed stability criteria is validated through standard numerical examples. | Krishnan RAMAKRISHNAN Goshaidas RAY | 2011 | 控制理论与应用(英文版)2011，9，4： | 16 |
| 3 | Review on mechanism and process of surface polishing using lasers显示文摘Laser polishing is a technology of smoothening the surface of various materials with highly intense laser beams. When these beams impact on the material surface to be polished, the surface starts to be melted due to the high temperature. The melted material is then relocated from the ‘peaks to valleys’ under the multidirectional action of surface tension. By varying the process parameters such as beam intensity, energy density, spot diameter, and feed rate, different rates of surface roughness can be achieved. High precision polishing of surfaces can be done using laser process. Currently, laser polishing has extended its applications from photonics to molds as well as bio-medical sectors. Conventional polishing techniques have many drawbacks such as less capability of polishing freeform surfaces, environmental pollution, long processing time, and health hazards for the operators. Laser polishing on the other hand eliminates all the mentioned drawbacks and comes as a promising technology that can be relied for smoothening of initial topography of the surfaces irrespective of the complexity of the surface. Majority of the researchers performed laser polishing on materials such as steel, titanium, and its alloys because of its low cost and reliability. This article gives a detailed overview of the laser polishing mechanism by explaining various process parameters briefly to get a better understanding about the entire polishing process. The advantages and applications are also explained clearly to have a good knowledge about the importance of laser polishing in the future. | Arun KRISHNAN Fengzhou FANG | 2019 | Frontiers of Mechanical Engineering2019，14，3： | 15 |
| 4 | 基于多特征融合的SVM声学场景分类算法研究显示文摘针对DCASE2017挑战赛的声场环境数据集,提取梅尔频率倒谱系数(MFCC)、短时能量(SE)、声学事件似然特征(AELF)、静音时间(MT)特征,组成多特征融合矩阵,通过对比多种核函数和寻优算法,最终选取高斯径向基核函数(RK)建立支持向量机(SVM)模型,采用交叉验证(CV)方法进行SVM参数寻优,对15种声学场景进行分类.实验结果表明,杂货店、办公室的分类准确性达到了90%以上,平均分类准确性达到71.11%,远高于挑战赛的基线系统61%的平均分类准确性. | 赵薇 靳聪 涂中文 SRIDHAR Krishnan 刘杉 | 2020 | 北京理工大学学报2020，40，1： | 13 |
| 5 | A universal strategy for the creation of machine learning-based atomistic force fields显示文摘Emerging machine learning(ML)-based approaches provide powerful and novel tools to study a variety of physical and chemical problems.In this contribution,we outline a universal strategy to create ML-based atomistic force fields,which can be used to perform high-fidelity molecular dynamics simulations.This scheme involves(1)preparing a big reference dataset of atomic environments and forces with sufficiently low noise,e.g.,using density functional theory or higher-level methods,(2)utilizing a generalizable class of structural fingerprints for representing atomic environments,(3)optimally selecting diverse and nonredundant training datasets from the reference data,and(4)proposing various learning approaches to predict atomic forces directly(and rapidly)from atomic configurations.From the atomistic forces,accurate potential energies can then be obtained by appropriate integration along a reaction coordinate or along a molecular dynamics trajectory.Based on this strategy,we have created model ML force fields for six elemental bulk solids,including Al,Cu,Ti,W,Si,and C,and show that all of them can reach chemical accuracy.The proposed procedure is general and universal,in that it can potentially be used to generate ML force fields for any material using the same unified workflow with little human intervention.Moreover,the force fields can be systematically improved by adding new training data progressively to represent atomic environments not encountered previously. | Tran Doan Huan Rohit Batra James Chapman Sridevi Krishnan Lihua Chen Rampi Ramprasad | 2017 | npj Computational Materials2017，，1： | 10 |
| 6 | Gastrointestinal complications of diabetes mellitus显示文摘Diabetes mellitus affects virtually every organ system in the body and the degree of organ involvement depends on the duration and severity of the disease,and other co-morbidities.Gastrointestinal(GI) involvement can present with esophageal dysmotility,gastro-esophageal reflux disease(GERD),gastroparesis,enteropathy,non alcoholic fatty liver disease(NAFLD) and glycogenic hepatopathy.Severity of GERD is inversely related to glycemic control and management is with prokinetics and proton pump inhibitors.Diabetic gastroparesis manifests as early satiety,bloating,vomiting,abdominal pain and erratic glycemic control.Gastric emptying scintigraphy is considered the gold standard test for diagnosis.Management includes dietary modifications,maintaining euglycemia,prokinetics,endoscopic and surgical treatments.Diabetic enteropathy is also common and management involves glycemic control and symptomatic measures.NAFLD is considered a hepatic manifestation of metabolic syndrome and treatment ismainly lifestyle measures,with diabetes and dyslipidemia management when coexistent.Glycogenic hepatopathy is a manifestation of poorly controlled type 1 diabetes and is managed by prompt insulin treatment.Though GI complications of diabetes are relatively common,awareness about its manifestations and treatment options are low among physicians.Optimal management of GI complications is important for appropriate metabolic control of diabetes and improvement in quality of life of the patient.This review is an update on the GI complications of diabetes,their pathophysiology,diagnostic evaluation and management. | Babu Krishnan Shithu Babu Jessica Walker Adrian B Walker Joseph M Pappachan | 2013 | World Journal of Diabetes2013，4，3： | 10 |
| 7 | Mercury remediation potential of a mercury resistant strain Sphingopyxis sp.SE2 isolated from contaminated soil显示文摘A mercury resistant bacterial strain SE2 was isolated from contaminated soil.The 16 s rRNA gene sequencing confirms the strain as Sphingopyxis belongs to the Sphingomonadaceae family of the α-Proteobacteria group.The isolate showed high resistance to mercury with estimated concentrations of Hg that caused 50%reduction in growth(EC_(50)) of 5.97 and 6.22 mg/L and minimum inhibitory concentrations(MICs) of 32.19 and 34.95 mg/L in minimal and rich media,respectively.The qualitative detection of volatilized mercury and the presence of mercuric reductase enzyme proved that the strain SE2 can potentially remediate mercury.ICP-QQQ-MS analysis of the remaining mercury in experimental broths indicated that a maximum of 44%mercury was volatilized within 6 hr by live SE2 culture.Furthermore a small quantity(23%) of mercury was accumulated in live cell pellets.While no volatilization was caused by dead cells,sorption of mercury was confirmed.The mercuric reductase gene merA was amplified and sequenced.Homology was observed among the amino acid sequences of mercuric reductase enzyme of different organisms from a-Proteobacteria and ascomycota groups, | Khandaker Rayhan Mahbub Kannan Krishnan Ravi Naidu Mallavarapu Megharaj | 2017 | Journal of Environmental Sciences2017，29，1： | 10 |
| 8 | Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection显示文摘AIM: To evaluate the prevalence of markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kolkata, Eastern India for two consecutive years and to conduct a pilot study to explore the presence of HBV DNA among hepatitis B surface antigen (HBsAg) negative but anti-HBc positive blood donors. METHODS: Seroprevalence of HBsAg, anti-HCV and anti-HIV was studied among 113 051 and 106 695 voluntary blood donors screened in 2004 and 2005, respectively. Moreover, a pilot study on 1027 HBsAg negative donors was carried out for evaluating the presence of HBV DNA by PCR on HBsAg negative/anti- HBc positive donors. RESULTS: A statistically significant increase in the prevalence of HBV (1448 vs 1768, P < 0.001), HIV (262 vs 374, P < 0.001), HCV (314 vs 372, P = 0.003) and syphilis (772 vs 853, P = 0.001) infections was noted among blood donors of Kolkata West Bengal in 2005 as compared to 2004. Moreover, the exploratory study on 1027 HBsAg negative donors revealed that 188 (18.3%)of them were anti-HBc positive out of which 21% were positive for HBV DNA. CONCLUSION: The findings of this study underscore the significantly increasing endemicity of hepatitis viruses, syphilis and HIV among the voluntary blood donors of our community. The pilot study indicates a high rate of prevalence of HBV DNA among HBsAg negative/anti-HBc positive donors and thus emphasizes the need for a more sensitive and stringent screening algorithm for blood donations. | Prasun Bhattacharya Partha Kumar Chandra Sibnarayan Datta Arup Banerjee Subhashish Chakraborty Krishnan Rajendran Subir Kumar Basu Sujit Kumar Bhattacharya Runu Chakravarty | 2007 | World Journal of Gastroenterology2007，13，27： | 9 |
| 9 | Isolation of the mucilages from Hibiscus rosasinensis linn.and Okra(Abelmoschus esculentus linn.) and studies of the binding effects of the mucilages显示文摘Objective:To isolate and evaluate comparatively the binding efficacy of the mucilages obtained from the plants of Hibiscus rosasinensis and Okra(Abelmoschus esculentus).Methods:Extraction of mucilages from the leaves of Hibiscus and pods of Okra(Ladies finger) was carried out by a cold maceration process.The extracted mucilages were subjected to various physicochemical properties for its suitability as an excipient in the formulation of tablet dosage form.Different concentrations(10,8,5,2 and 1%w/v) of binder solutions of Hibiscus and Okra were used for the formulation of tablets and the formulated tablets were evaluated by studying the standard parameters like diameter,thickness,weight variation,hardness,friability,disintegration and in vitro dissolution.Stability studies of the formulated tablets were conducted for four weeks. Results:The formulated tablets prepared using the mucilages of both Hibiscus and Okra had good appearance.The in vitro drug release profile of the tablets prepared using Okra mucilage had an optimum of 90%at a mucilage concentration of 1%w/v concentration mucilage itself within 4 h.Conclusions:According to the observations,the lower concentration levels of Okra can be used as an alternative binder to starch.The higher concentration levels of Okra mucilage show a slow and sustained release,and can be considered as an alternative natural excipient in the modified drug delivery systems.At the same time,the above natural excipient of Hibiscus mucilage could be used as a platform for prolonged release if its binder concentrations are increased. | Ameena K Dilip C Saraswathi R Krishnan PN Sankar C Simi SP | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 8 |
| 10 | Erasure coding for distributed storage: an overview显示文摘In a distributed storage system, code symbols are dispersed across space in nodes or storage units as opposed to time. In settings such as that of a large data center, an important consideration is the efficient repair of a failed node. Efficient repair calls for erasure codes that in the face of node failure,are efficient in terms of minimizing the amount of repair data transferred over the network, the amount of data accessed at a helper node as well as the number of helper nodes contacted. Coding theory has evolved to handle these challenges by introducing two new classes of erasure codes, namely regenerating codes and locally recoverable codes as well as by coming up with novel ways to repair the ubiquitous Reed-Solomon code. This survey provides an overview of the efforts in this direction that have taken place over the past decade. | S.B.BALAJI M.Nikhil KRISHNAN Myna VAJHA Vinayak RAMKUMAR Birenjith SASIDHARAN P.Vijay KUMAR | 2018 | Science China(Information Sciences)2018，61，10： | 8 |
| 11 | Transcranial magnetic stimulation for geriatric depression: Promises and pitfalls显示文摘As the global population gets older, depression in the elderly is emerging as an important health issue. A major challenge in treating geriatric depression is the lack of robust efficacy for many treatments that are of significant benefit to depressed working age adults. Repetitive transcranial magnetic stimulation(r TMS) is a novel physical treatment approach used mostly in working age adults with depression. Many TMS trials and clinics continue to exclude the elderly from treatment citing lack of evidence in this age group. In this review, we appraise the evidence regarding the safety and efficacy of rT MS in the elderly. A consistent observation supporting a high degree of tolerability and safety among the elderly patients emerged across the Randomised Controlled Trials and the uncontrolled trials. Further, there is no reliable evidence negating the utility of rT MS in the elderly with depression. We also identified several factors other than age that moderate the observed variations in the efficacy of rT MS in the elderly. These factors include but not limited to:(1) brain atrophy;(2) intensity and number of pulses(dose-response relationship); and(3) clinical profile of patients. On the basis of the current evidence, the practice of excluding elderly patients from TMS clinics and trials cannot be supported. | Priyadharshini Sabesan Sudheer Lankappa Najat Khalifa Vasudevan Krishnan Rahul Gandhi Lena Palaniyappan | 2015 | World Journal of Psychiatry2015，5，2： | 7 |
| 12 | 印度小圆胸小蠹的一种新寄主植物(英文)显示文摘自然条件下印度小圆胸小蠹Euwallacea fornicatus(Eichhoff,1868)在茶树枝条虫瘿内取食,是茶的重要害虫之一,以茶蛀虫著称。2010年5-8月,在印度MugaEri研究中心3号农场(Lahdoigarh,Jorhat-Assam)的黄心树Persea bombycina Kost.(樟科)种植园中发现该虫有自然分布,且已对黄心树造成了明显的危害。黄心树为小圆胸小蠹一种新纪录的寄主植物。本文对小圆胸小蠹的寄主范围、分布、生物学和生活史等进行了讨论。 | Rajesh KUMAR Girin RAJKHOWA Mattipalli SANKAR Rama Krishnan RAJAN | 2011 | 昆虫学报2011，54，6： | 7 |
| 13 | Biosorption of Cd (Ⅱ) and Pb (Ⅱ) Ions by Aqueous Solutions of Novel Alkalophillic Streptomyces VITSVK5 spp. Biomass显示文摘Discharge of heavy metals from metal processing industries is known to have adverse effects on the environment.Bio-sorption of heavy metals by metabolically inactive biomass of microbial organisms is an innovative and alternative technology for removal of these pollutants from aqueous solution.The search of marine actinobacteria with potential heavy metal biosorption ability resulted in the identification of a novel alkalophilic Streptomyces VITSVK5 species.The biosorption property of Streptomyces VITSVK5 spp.was investigated by absorbing heavy metals Cadmium (Cd) and Lead (Pb).Physiochemical characteristics and trace metal concentration analysis of the backwater showed the concentrations of different metals were lead 13±2.1 μg L-1,cadmium 3.1±0.3μg L-1,zinc 8.4±2.6μg L-1 and copper 0.3±0.1μg L-1,whereas mercury was well below the detection limit.The effect of pH and biomass dosage on removal efficiency of heavy metal ions was also investigated.The optimum pH for maximal biosorption was 4.0 for Cd (II) and 5.0 for Pb (II) with 41% and 84% biosorption respectively.The biosorbent dosage was optimized as 3 g L-1 for both the trace metals.Fourier transform infrared absorption spectrum results indicated the chemical interactions of hydrogen atoms in carboxyl (–COOH),hydroxyl (–CHOH) and amine (–NH2) groups of biomass with the metal ions.This could be mainly involved in the biosorption of Cd (II) and Pb (II) onto Streptomyces VITSVK5 spp.The results of our study revealed Streptomyces metabolites could be used to develop a biosorbent for adsorbing metal ions from aqueous environments. | Kumar Saurav Krishnan Kannabiran | 2011 | Journal of Ocean University of China2011，10，1： | 6 |
| 14 | 孤独症患者脑内神经胶质细胞的激活和神经炎症 | Vargas D.L. Nascimbene C. Krishnan C. C.A. Pardo 郭俊 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，5： | 6 |
| 15 | Management of neglected cervical spine dislocation: a study of six cases显示文摘没有神经病学的赤字的六忽视的颈的脊骨脱臼的一个案例系列,它是管理了 operatively.MethodsThe 学习的 ObjectiveTo 报告从 2010 年 8 月被进行到 2011 年 12 月,案例从医药教育和研究的研究生研究所的门诊部被选择,印度。病人在 30 ~ 50 年的年龄组。所有病人经由前面、以后的 approaches.ResultsDuring 被操作立即的手术后的时期,五(83.33%) 病人们有正常神经病学的地位。有 C 5-C6 subluxation 的(16.67%)病人在在更低的手足的 2/5 和在在 C 6 level.ConclusionThere 下面的上面的手足的 3/5 的水平和马达功率是的 C 6下面与感觉损失开发了神经病学的赤字在对颈的脊骨的忽视的分散注意力的屈曲损害的颅骨拖拉的角色都没为更多推迟比 3 个星期。以后由前面的途径列在后面节省许多时间。如果两条途径将在一样的坐被做,其次地对乐器学没有需要。但是如果上演过程是 planed,以后的稳定被推荐,,有在神经病学的地位的恶化的风险。 | Vijay Goni Nirmal Raj Gopinathan Vibhu Krishnan Rajesh Kumar Avinash Kumar | 2013 | Chinese Journal of Traumatology2013，16，4： | 6 |
| 16 | Biosorption of Cr(Ⅳ),Cr(Ⅲ),Pb(Ⅱ) and Cd(Ⅱ) from Aqueous Solutions by Sargassum wightii and Caulerpa racemosa Algal Biomass显示文摘Heavy metal pollution is one of the most important environmental problems today.Biosorption is an innovative tech-nology that employs biological materials to accumulate heavy metals from waste water through metabolic process or physicochemi-cal pathways of uptake.Even though several physical and chemical methods are available for removal of heavy metals,currently many biological materials such as bacteria,algae,yeasts and fungi have been widely used due to their good performance,low cost and large quantity of availability.The aim of the present study is to explore the biosorption of toxic heavy metals,Cr(VI),Cr(III),Pb(II) and Cd(II) by algal biomass obtained from algae Sargassum wightii(brown) and Caulerpa racemosa(green).Biosorption of algal biomass was found to be biomass concentration-and pH-dependent,while the maximal biosorption was found at pH 5.0 and with the metal concentration of 100 mg L-1.S.wightii showed the maximal metal biosorption at the biomass concentration of 25 g L-1,followed by C.racemosa with the maximal biosorption at 30 g L-1.S.wightii showed 78% biosorption of Cr(VI),Cr(III),Pb(II) and Cd(II) ions.C.racemosa exhibited 85% biosorption of Cd(II) and Cr(VI),and 50% biosorption of Cr(III) and Pb(II).The results of our study suggest that seaweed biomass can be used efficiently | Narayanaswamyb Tamilselvan Kumar Saurav Krishnan Kannabiran | 2012 | Journal of Ocean University of China2012，11，1： | 6 |
| 17 | Ipsilateral fracture dislocations of the hip and knee joints with contralateral open fracture of the leg: a rare case and its management principles显示文摘这份报纸讨论了损害机制和有的伴随物 ipsilateral 臀部和膝脱臼和 contralateral 打开腿骨折的一个病人的管理。一个 32 岁的人与左臀部(小瓦锅的类型 IV ) 和关节和 contralateral 张开的膝(穆尔二世) 的 ipsilateral 破裂脱臼介绍了在一个汽车事故以后的腿骨头的骨折。在紧急情况以后使复生的措施,新潮的关节被减少,小瓦锅的破裂用 Ganz 途径被修理与落后螺丝钉;膝关节仔细被减少,胫骨的高原骨折与跨越 fixator 的侧面的撑墙板和 transarticular 被稳定。另外的腿上的开的破裂与外部 fixator 被清除并且修理。当他在麻醉下面被检查时,在在固定以后的两个关节没有不稳定性。破裂在 3 个月以后联合起来,病人没有臀部和膝的剩余不稳定性。没有在在 6 个月以后的新潮的关节的 osteonecrosis 的临床或放射学的证据。在一个年后续,他在两个关节与运动的几乎正常范围有令人满意的功能的结果。Ipsilateral 臀部和膝脱臼是稀罕损害,更多的小心为早诊断被需要。及时适当干预能处于这种状况提供好功能的结果给病人。 | Ramesh Kumar Sen Sujit Kumar Tripathy Vibhu Krishnan Tarun Goyal Vanyambadi Jagadeesh | 2011 | Chinese Journal of Traumatology2011，14，3： | 5 |
| 18 | Nonsaturation Throughput Enhancement of IEEE 802.11b Distributed Coordination Function for Heterogeneous Traffic under Noisy Environment显示文摘In this paper, we propose a mechanism named modified backoff (MB) mechanism to decrease the channel idle time in IEEE 802.11 distributed coordination function (DCF). In the noisy channel, when signal-to-noise ratio (SNR) is low, applying this mechanism in DCF greatly improves the throughput and lowers the channel idle time. This paper presents an analytical model for the performance study of IEEE 802.11 MB-DCF for nonsaturated heterogeneous traffic in the presence of transmission errors. First, we introduce the MB-DCF and compare its performance to IEEE 802.11 DCF with binary exponential backoff(BEB). The IEEE 802.11 DCF with BEB mechanism suffers from more channel idle time under low SNR. The MB-DCF ensures high throughput and low packet delay by reducing the channel idle time under the low traffic in the network. However, to the best of the authors knowledge, there are no previous works that enhance the performance of the DCF under imperfect wireless channel. We show through analysis that the proposed mechanism greatly outperforms the original IEEE 802.11 DCF in the imperfect channel condition. The effectiveness of physical and link layer parameters on throughput performance is explored. We also present a throughput investigation of the heterogeneous traffic for different radio conditions. | Dhanasekaran Senthilkumar A. Krishnan | 2010 | International Journal of Automation and computing2010，7，1： | 5 |
| 19 | Anti-chikungunya activity of luteolin and apigenin rich fraction from Cynodon dactylon显示文摘Objective:To obtain Iuteolin and apigenin rich fraction from the ethanolic extract of Cynodon dactylon(L.)(C.dactylon) Pers and evaluate the fraction's cytotoxicity and anti-Chikungunya potential using Vero cells.Methods:The ethanolic extract of C.dactylon was subjected to silica gel column chromatography to obtain anti-chikungunya virus(CHIKV) fraction.Reverse phase-HPLC and GC-MS studies were carried out to identily the major phytochemicals in the fraction using phylochemical standards.Cytotoxicity and the potential of the fraction against CHIKV were evaluated in vitro using Vero cells.Reduction in viral replication was assessed by reverse transcriptase-polymerase chain reaction(RT-PCR) after treating the viral infected Vero cells with the fraction.Results:Reverse Phase-HPLC and GC-MS studies confirmed the presence of flavonoids,luteolin and apigenin as major phytochemicals in the anti-CHIKV ethanolic fraction of C.dactylon- The fraction was found to exhibit potent viral inhibitory activity(about 98%) at the concentration of 50 μg/mL as observed by reduction in cytopathic effect,and the cytotoxic concentration of the fraction was found to be 250 μg/mL.RT-PCR analyses indicated that the reduction in viral mRNA synthesis in fraction treated infected cells was much higher than the viral infected control cells.Conclusions:Luteolin and apigenin rich ethanolic fraction from C.dactylon can be utilized as a potential therapeutic agent against CHIKV infection as the fraction does not show cytotoxicity while inhibiting the virus. | Krishnan Saravana Murali Srinivasan Sivasubramanian Savariar Vincent Shanmugaraj Bala Murugan Bupesh Giridaran Sundaram Dinesh Palani Gunasekaran Kaveri Krishnasamy Ramalingam Sathishkumar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 5 |
| 20 | COVID-19: An overview and a clinical update显示文摘The outbreak of coronavirus disease-2019(COVID-19,previously known as 2019 nCoV)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in Wuhan City,China,has spread rapidly around the world.Most patients from the first cluster had an epidemiological connection to the Wuhan's Huanan Seafood Wholesale Market.Available evidence has shown that SARSCoV-2 can be easily transmitted from person to person through close contact and respiratory droplets,posing a substantial challenge to public health.At present,the research on SARS-CoV-2 is still in the primary stages.However,dexamethasone and remdesivir are appeared to be promising medical therapies.Still,there is no definite specific treatment,and the mainstay of treatment is still focused on supportive therapies.Currently,over 150 vaccines are under investigation.It is necessary to understand the nature of the virus and its clinical characteristics in order to find effectively manage the disease.The knowledge about this virus is rapidly evolving,and clinicians must update themselves regularly.The present review comprehensively summarizes the epidemiology,pathogenesis,clinical characteristics,and management of COVID-19 based on the current evidence. | Arunkumar Krishnan James P Hamilton Saleh A Alqahtani Tinsay A Woreta | 2021 | World Journal of Clinical Cases2021，9，1： | 5 |
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