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| 1 | Isolation of the mucilages from Hibiscus rosasinensis linn.and Okra(Abelmoschus esculentus linn.) and studies of the binding effects of the mucilages显示文摘Objective:To isolate and evaluate comparatively the binding efficacy of the mucilages obtained from the plants of Hibiscus rosasinensis and Okra(Abelmoschus esculentus).Methods:Extraction of mucilages from the leaves of Hibiscus and pods of Okra(Ladies finger) was carried out by a cold maceration process.The extracted mucilages were subjected to various physicochemical properties for its suitability as an excipient in the formulation of tablet dosage form.Different concentrations(10,8,5,2 and 1%w/v) of binder solutions of Hibiscus and Okra were used for the formulation of tablets and the formulated tablets were evaluated by studying the standard parameters like diameter,thickness,weight variation,hardness,friability,disintegration and in vitro dissolution.Stability studies of the formulated tablets were conducted for four weeks. Results:The formulated tablets prepared using the mucilages of both Hibiscus and Okra had good appearance.The in vitro drug release profile of the tablets prepared using Okra mucilage had an optimum of 90%at a mucilage concentration of 1%w/v concentration mucilage itself within 4 h.Conclusions:According to the observations,the lower concentration levels of Okra can be used as an alternative binder to starch.The higher concentration levels of Okra mucilage show a slow and sustained release,and can be considered as an alternative natural excipient in the modified drug delivery systems.At the same time,the above natural excipient of Hibiscus mucilage could be used as a platform for prolonged release if its binder concentrations are increased. | Ameena K Dilip C Saraswathi R Krishnan PN Sankar C Simi SP | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 8 |
| 2 | Anti-inflammatory activity of the leaf extacts of Gendarussa vulgaris Nees显示文摘Objective:To evaluate the anti-inflammatory property of the leaf exacts of Gendarussa vulgaris(G.vulgarix) Nees.Methods:G.vulgarix Nees of the family Apocynaceae is a medium sized tree grown in semishade or no shade and is common in the Ernad and Nilambur taluks of Kerala. Various parts of this plant have been used in the treatment of ulcers,sores,inflammation, dyspepsia,healing of wounds,etc.The present study aimed at the evaluation of anti-inflammatory property of the aqueous and alcoholic extracts of the leaves by both in vitro and in vivo methods. In vitro method was estimated by human red blood cell membrane stabilisation(HRBC) method and in vivo method was estimated on the carrageenan induced paw oedima.Results:Both the methods showed significant anti-inflammatory property of the different extracts tested. Conclusions:The alcoholic extract at a concentration of 300 mg/mL showed potent activity on comparing with the standard drug diclofenac sodium. | TK Mohamed Saleem AK Azeem C Dilip C Sankar NV Prasanth R Duraisami | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 3 |
| 3 | L-asparaginase production by mangrove derived Bacillus cereus MAB5:optimization by response surface methodology显示文摘Objective:To isolate marine bacteria,statistically optimize them for maximum asparaginase production.Methods:In the present study,statistically based experimental designs were applied to maximize the production of L-asparaginase from bacterial strain of Bacillus cereus(B.cereus) MAB5(HQ675025) isolated and identified by 16S rDNA sequencing from mangroves rhizosphere sediment.Results:Plackett-Barman design was used to identify the interactive effect of the eight variables viz.yeast extract,soyabean meal,glucose,magnesium sulphate,KH2PO4,wood chips,aspargine and sodium chloride.All the variables are denoted as numerical factors and investigated at two widely spaced intervals designated as -1(low level) and +1(high level). The effect of individual parameters on L-asparaginase production was calculated.Soyabean meal,aspargine,wood chips and sodium chloride were found to be the significant among eight variables.The maximum amount of L-asparaginase produced(51.54 IU/mL) from the optimized medium containing soyabean meal(6.282 8 g/L),aspargine(5.5 g/L),wood chips(1.383 8 g/L) and NaCl(4.535 4 g/L).Conclusions:The study revealed that,it is useful to produce the maximum amount of L-asparaginase from B.cereus MAB5 for the treatment of various infections and diseases. | Thenmozhi C Sankar R Karuppiah V Sampathkumar P | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 2 |
| 4 | Combining Feature Reduction and Case Selection in Building CBR Classifiers 显示文摘 | LI Yah Simon C K Shin Sankar K Pal | 2006 | IEEE Transactions on Knowledge and data Engineering2006，18，3： | 1 |
| 5 | Numerical simulation of the aerodynamics of horizontal axis wind turbines under yawed flow conditions显示文摘 | Tongchitpakdee C Benjanirat S Sankar L N | 2005 | Journal of Solar Energy Engineering2005，127，4： | 1 |
| 6 | Following the formation of y-phase Bi2MoO6 catalyst by in situ XRD/XAS and thermogravimetric techniques显示文摘 | REILLY L M SANKAR G CATLOW C R A | | 0，，1： | 1 |
| 7 | Doing better at doing good: when,why, and how consumers respond to corporate social initiatives 显示文摘 | Bhattacharya C B Sankar Sen | 2004 | California Management Review2004，47，1： | 1 |
| 8 | Sodium alginate micro spheres of metoprolol tartrate for intranasal systemic delivery: development and evaluation 显示文摘 | Rajinikanth PS Sankar C Mishra B | 2003 | Drug Deliv2003，10，1： | 1 |
| 9 | β-TrCP mediates the signal-induced ubiquitination of IκB显示文摘 | Wu C Sankar G | 1999 | J Biol Chem1999，274，29： | 1 |
| 10 | Does doing good always lead to doing better? Consurner reactions to corporate social responsibility显示文摘 | Sen Sankar and C B Bhattacharya | 2001 | Journal of Marketing Research2001，38，5： | 1 |
| 11 | Does Doing Good Always Lead to Doing Better? Consumer Reactions to Corporate Social Responsibility 显示文摘 | SANKAR S BHATFACHARYA C B | 2001 | Journal of Marketing Research2001，38，2： | 1 |
| 12 | Consumer-Company Identifieation: A Framework for Understanding Consumers' Relationships with Companies 显示文摘 | BHATTACHARYA C B SANKAR SEN | 2003 | Journal of Marketing2003，，67： | 1 |
| 13 | Differential re-sponses in water use efficiency in two varieties of ca-tharan-thus roseus under drought stress显示文摘 | Jaleel C A Gopi R Sankar B | 2008 | C R Biol2008，331，1： | 1 |
| 14 | Paclobutrazol enhances photosynthesis and ajmalicine production in C(tharanghus roseus显示文摘 | Jaleel C A Manivannan P Sankar B | 2007 | Process Biochem2007，42，11： | 1 |
| 15 | Doing Better at Doing Good 显示文摘 | Bhattacharya C B Sankar Sen | 2004 | Cali- fornia Management Review2004，47，1： | 1 |
| 16 | A Survey of 4WD Traction Control Systems and Strategies显示文摘 | Sankar K M Randolph C W | | SAE Paper0，1995，： | 1 |
| 17 | Does Doing Good always Lead to Doing Better? Consumer Reactions to Corporate Social Responsibility 显示文摘 | Sen Sankar Bhattacharya C B | 2001 | Journal of Marketing Research2001，38，2： | 1 |
| 18 | Voltammetric procedure for examining DNA - modified surfaces : quantitation, cationicbinding activity, and electron- transfer kinetics显示文摘 | Yu H Z Luo C Y Sankar C G | 2003 | Analytical Chemistry2003，75，15： | 1 |
| 19 | Rotary heat exchanger performance with axial heat dispersion 显示文摘 | SANKAR N SAMIR V DHINGRA S C | 1998 | International Journal of Heat and Mass Transfer1998，，41： | 1 |
| 20 | Does doing good always lead to doing better? Consumer reactions to corporate 显示文摘 | Sankar Sen C B Bhattachatya | 2001 | Journal of Marketing Research2001，5，： | 1 |
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