维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

1篇 您的检索式：作者名="Kristof Bozovicar"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders显示文摘BACKGROUND Endothelin(ET)-traps are Fc-fusion proteins with a design based on the physiological receptors of ET-1.Previous work has shown that use of the selected ET-traps potently and significantly reduces different markers of diabetes pathology back to normal,non-disease levels.AIM To demonstrate the selected ET-traps potently and significantly bind to ET-1.METHODS We performed phage display experiments to test different constructs of ET-traps,and conducted bio-layer interferometry binding assays to verify that the selected ET-traps bind specifically to ET-1 and display binding affinity in the double-digit picomolar range(an average of 73.8 rM,n=6).RESULTS These experiments have confirmed our choice of the final ET-traps and provided proof-of-concept for the potential use of constructs as effective biologics for diseases associated with pathologically elevated ET-1.CONCLUSION There is increased need for such therapeutics as they could help save millions of lives around the world.	Arjun Jain Kristof Bozovicar Vidhi Mehrotra Tomaz Bratkovic Martin H Johnson Ira Jha	2022	World Journal of Diabetes2022，13，6：	0

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费