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| 1 | Computational Study on the Effect of Inlet Port Con- figuration on In-Cylinder Flow of a Motored Four- Valve Internal Combustion Engine显示文摘 | Hoong T Toh Rong F Huang Kuan H Lin | 2011 | Journal of Ener- gy Engineering2011，137，4： | 1 |
| 2 | Therapeutic effects of lidocaine patch on myofascial pain syndrome of the upper trapezius: a ran- domized,double-blind,placebo-controlled study显示文摘 | Lin Y C Kuan T S H sieh P C | 2012 | Am J Phys Med Rehabil2012，91，10： | 1 |
| 3 | Beaming light from a subwavelength metal slit surrounded by dielectric surface grat- ings 显示文摘 | Lin D Z Chang C K Chen Y C Yang D L Lin M W Yeh J T Liu J M Kuan C H Yeh C S Lee C K | 2006 | Optics Express2006，14，8： | 1 |
| 4 | Multi-walled carbon nanotube reinforced poly (L-lactic acid) nanocomposites enhanced by water-crosslinking reaction显示文摘 | Kuan C F Chen C H Kuan H C Lin K C Chiang C L Peng H C | 2008 | J Phys Chem Solids2008，69，56： | 1 |
| 5 | A multilayered parallel coupled microstrip bandpass filter with embedded SIR cells to have a broad upper rejection band 显示文摘 | KUAN H LIN Y L YANG R Y | 2010 | IEEE Microwave and Wireless Components Letters2010，20，1： | 1 |
| 6 | Methods for accelerating nitrate reduction using zerovalent iron at near-neutral pH: Effects of H2-reducing pretreatment and copper deposition 显示文摘 | Liou Y H Lo S L Lin C J Hu C Y Kuan W H Weng S C | 2005 | Environmental Science and Technology2005，39，： | 1 |
| 7 | Causality in quan- tiles and dynamic stock return-volume relations显示文摘 | Chuang C C Kuan C M Lin H Y | 2009 | Journal of Banking and Finance2009，33，： | 1 |
| 8 | Reliable Multicast and Broadcast Mecha- nisms for Energy-Harvesting Devices 显示文摘 | Kuan C Lin G Wei H | 2014 | IEEE Transactions on Vehicular Technology2014，63，4： | 1 |
| 9 | Causality in quantiles and dynamic stock return-volume relations显示文摘 | Chuang C C Kuan C M Lin H Y | 2009 | Journal of Banking & Finance2009，33，7： | 1 |
| 10 | Analysis of the dark current in the bulk of InAs diode detectors 显示文摘 | C H Kuan R M Lin S F Tang | 1996 | Journal of Applied Physics1996，80，9： | 1 |
| 11 | Synthesis and preliminary evaluation of novel^(11)C-labeled GluN2B-selective NMDA receptor negative allosteric modulators显示文摘N-methyl-D-aspartate receptors(NMDARs)play critical roles in the physiological function of the mammalian central nervous system(CNS),including learning,memory,and synaptic plasticity,through modulating excitatory neurotransmission.Attributed to etiopathology of various CNS disorders and neurodegenerative diseases,GluN2B is one of the most well-studied subtypes in preclinical and clinical studies on NMDARs.Herein,we report the synthesis and preclinical evaluation of two^(11)C-labeled GluN2B-selective negative allosteric modulators(NAMs)containing N,N-dimethyl-2-(1H-pyrrolo[3,2-b]pyridin-1-yl)acetamides for positron emission tomography(PET)imaging.Two PET ligands,namely[^(11)C]31 and[^(11)C]37(also called N2B-1810 and N2B-1903,respectively)were labeled with[^(11)C]CH3I in good radiochemical yields(decay-corrected 28%and 32%relative to starting[^(11)C]CO_(2),respectively),high radiochemical purity(>99%)and high molar activity(>74 GBq/μmol).In particular,PET ligand[^(11)C]31 demonstrated moderate specific binding to GluN2B subtype by in vitro autoradiography studies.However,because in vivo PET imaging studies showed limited brain uptake of[^(11)C]31(up to 0.5 SUV),further medicinal chemistry and ADME optimization are necessary for this chemotype attributed to low binding specificity and rapid metabolism in vivo. | Ji-yun Sun Katsushi Kumata Zhen Chen Yi-ding Zhang Jia-hui Chen Akiko Hatori Hua-long Fu Jian Rong Xiao-yun Deng Tomoteru Yamasaki Lin Xie Kuan Hu Masayuki Fujinaga Qing-zhen Yu Tuo Shao Thomas Lee Collier Lee Josephson Yi-han Shao Yun-fei Du Lu Wang Hao Xu Ming-rong Zhang Steven H Liang | 2021 | Acta Pharmacologica Sinica2021，42，3： | 0 |
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