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| 1 | Intrahepatic distribution of hepatitis B virus antigens in patients with and without hepatocellular carcinoma显示文摘AIM: To study the intrahepatic expression of hepatitis B surface antigen(HBs Ag) and hepatitis B core antigen(HBc Ag) in chronic hepatitis B patients with and without hepatocellular carcinoma. METHODS: A total of 33 chronic hepatitis B patients(mean age of 40.3 ± 2.5 years), comprising of 14 HBe Ag positive and 19 HBe Ag negative patients; and 13 patients with hepatitis B virus related hepatocellular carcinoma(mean age of 49.6 ± 4.7 years), were included in our study. Immunohistochemical staining for HBc Ag and HBs Ag was done using standard streptavidin-biotin-immunoperoxidase technique on paraffin-embedded liver biopsies. The HBc Agand HBs Ag staining distributions and patterns were described according to a modified classification system. RESULTS: Compared to the HBe Ag negative patients, the HBe Ag positive patients were younger, had higher mean HBV DNA and alanine transaminases levels. All the HBe Ag positive patients had intrahepatic HBc Ag staining; predominantly with 'diffuse' distribution(79%) and 'mixed cytoplasmic/nuclear ' pattern(79%). In comparison, only 5% of the HBe Ag-negative patients had intrahepatic HBc Ag staining. However, the intrahepatic HBs Ag staining has wider distribution among the HBe Ag negative patients, namely; majority of the HBe Ag negative cases had 'patchy' HBs Ag distribution compared to 'rare' distribution among the HBe Ag positive cases. All but one patient with HCC were HBe Ag negative with either undetectable HBV DNA or very low level of viremia. Intrahepatic HBc Ag and HBs Ag were seen in 13(100%) and 10(77%) of the HCC patients respectively. Interestingly, among the 9 HCC patients on anti-viral therapy with suppressed HBV DNA, HBc Ag and HBs Ag were detected in tumor tissues but not the adjacent liver in 4(44%) and 1(11%) patient respectively. CONCLUSION: Isolated intrahepatic HBc Ag and HBs Ag can be present in tumors of patients with suppressed HBV DNA on antiviral therapy; that may predispose them to cancer development. | Parham Safaie Mugilan Poongkunran Ping-Ping Kuang Asad Javaid Carl Jacobs Rebecca Pohlmann Imad Nasser Daryl TY Lau | 2016 | World Journal of Gastroenterology2016，22，12： | 5 |
| 2 | Factors associated with the stability of mini - implants for orthodontic anchorage:a study of 414 samples in Taiwan 显示文摘 | Wu TY Kuang SH Wu CH | 2009 | J Oral Maxillofac Surg2009，67，8： | 1 |
| 3 | Factors associated with the stability of mini-implants for orthodontic anchorage: a study of 414 samples in Taiwan 显示文摘 | Wu TY Kuang SH Wu CH | 2009 | Journal of Oral and Maxillofacial Surgery2009，67，8： | 1 |
| 4 | Three-dimensional architecture of phycobilisomes from Nostoc falgelliforme revealed by single particle electron microscopy显示文摘 | YI ZW HUANG H KUANG TY SUI SF | 2005 | FEBS Letters2005，579，： | 1 |
| 5 | Molecular cloning,in vitro expression and enzyme activity analysis of violaxan-thin de-epoxidase from Oryza sativa L.显示文摘The violaxanthin de-epoxidase gene was cloned from rice (Oryza sativa subsp. japonica). The full length of the cDNA is 1887 bp, encoding a 446-amino acids protein with the transit peptide of 98 amino acids. The bacterial expression vector pET-Rvde was constructed and the expression quantity of the exogenous protein increased with the induction time by 0.4 mmol/L IPTG. Its molecular weight was similar with that of the native VDE. Western blotting indicated that the expressed protein has immu-nological reaction with the VDE polyclonal antibody. The absorbance spectrum together with xanthophyll pigments quantification by HPLC demonstrated that the expressed VDE has its enzyme activity, which can de-epoxidate violaxanthin into antheraxanthin and zeaxanthin in vitro. | Lin, RC Li, LB Kuang, TY | 2002 | Chinese Science Bulletin2002，47，11： | 1 |
| 6 | Factors associated with the stability of mini-implants for orthodontic anchorage:a study of 414 samples in Taiwan显示文摘 | Wu TY Kuang SH Wu CH | 2009 | J Oral Maxillofac Surg2009，67，8： | 1 |
| 7 | Factors associated with the stability of mini-implants for orthodontic anchorage:a study of 414 samples in Tai- wan 显示文摘 | Wu TY Kuang SH Wu CH | 2009 | J Oral MaxiUofac Surg2009，67，8： | 1 |
| 8 | The origin of the long wavelength fluorescence mission band (77 K) from photosystem I 显示文摘 | Kuang TY Argyroucli-Akoyunoglou JH Nakatam HY | 1984 | Arch Biochem Biophys1984，235，： | 1 |
| 9 | Effect of various temperatures on phosphatidylglycerol biosynthesis in thylakoid membranes显示文摘 | Xu YN Wang ZN Jiang GZ Li LB Kuang TY | | 0，，： | 1 |
| 10 | Factors associated with the stability of mini-implants for orthodontic anchorage: a study of 414 samples in Taiwan显示文摘 | Wu TY Kuang SH Wu CH | 2009 | J Oral Maxillofac Surg2009，67，8： | 1 |
| 11 | Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo 显示文摘 | Ojogun N Kuang TY Shao B | 2009 | J Infect Dis2009，200，11： | 1 |
| 12 | Factors associated with the stability of mini-implants for orthodontic anchorage: a study of 414 samples in Taiwan显示文摘 | Wu TY Kuang SH Wu CH | 2009 | l Oral Maxillofac- Surg2009，67，8： | 1 |
| 13 | The non-structural 5A protein of hepatitis C virus exhibits genotypic differences in interferon antagonism显示文摘 | Tsai YH Kuang WF Lu TY | 2008 | J Hepatol2008，49，6： | 1 |
| 14 | Factors associated with the stability of mini-implants for orthodontic anchorage: a study of 414 samples in Taiwan显示文摘 | Wu TY Kuang SH Wu CH | 2009 | J Oral Maxillofac Surg2009，67，8： | 1 |
| 15 | Factors associated with the stability of mini-implants for orthodontic anchorage:a study of 414 samples in Taiwan显示文摘 | Wu TY Kuang SH Wu CH | 2009 | J Oral Maxillofac Surg2009，67，8： | 1 |
| 16 | Genes differentially expressed under photoinhibition stress in flag leaves of super-hybrid rice Liangyoupeijiu (Oryza sativa) and their genetic origins显示文摘 | Jiang, GQ Guo, JL Meng, QW Chen, YQ Wang, HX Hu, ZA Kuang, TY | 2006 | 中国生物学文摘2006，20，2： | 0 |
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