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| 1 | Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury显示文摘In chronic phase of spinal cord injury, functional recovery is more untreatable compared with early intervention in acute phase of spinal cord injury. In the last decade, several combination therapies successfully improved motor dysfunction in chronic spinal cord injury. However, their effectiveness is not sufficient. We previously found a new effective compound for spinal cord injury, matrine, which induced axonal growth and functional recovery in acute spinal cord injury mice via direct activation of extracellular heat shock protein 90. Although our previous study clarified that matrine was an activator of extracellular heat shock protein 90, the potential of matrine for spinal cord injury in chronic phase has not been sufficiently evaluated. Thus, this study aimed to investigate whether matrine ameliorates chronic spinal cord injury in mice. Once daily intragastric administration of matrine(100 μmol/kg per day) to spinal cord injury mice were starte at 28 days after injury, and continued for 154 days. Continuous mat rine treatment improved hindlimb motor function in chronic spinal cord injury mice. In injured spinal cords of the matrine-treated mice, the density of neurofilament-H-positive axons was increased. Moreover, matrine treatment increased the density of bassoon-positive presynapses in contact with choline acetyltransferase-positive motor neurons in the lumbar spinal cord. These findings suggest that matrine promotes remodeling and reconnection of neural circuits to regulate hindlimb movement. All protocols were approved by the Committee for Animal Care and Use of the Sugitani Campus of the University of Toyama(approval No. A2013 INM-1 and A2016 INM-3) on May 7, 2013 and May 17, 2016, respectively. | Norio Tanabe Tomoharu Kuboyama Chihiro Tohda | 2019 | Neural Regeneration Research2019，14，11： | 5 |
| 2 | Formation of hydrogen-capped polyynes by laser ablation of C60 particles suspended in solution显示文摘 | Tsuji M Kuboyama S Matsuzaki T | 2003 | Carbon2003，41，11： | 2 |
| 3 | A biodegradable porous composite scaffold of PGA/IB-TCP for hone tissue engineering 显示文摘 | Cao H Kuboyama N | 2010 | Bone2010，46，2： | 1 |
| 4 | Complex blockade of TTX-resiatant Na + currents by lidocaine and bupivacaine reduce firing frequency in DRG neurons显示文摘 | Scholz A Kuboyama N Hempelmann G | 1998 | J neurophysiol1998，79，4： | 1 |
| 5 | Local and pseudo SELs observed in digital LSIs and their implication to SEL test method 显示文摘 | SHINDOU H KUBOYAMA S HIRAO T | 2005 | IEEE Trans Nuel Sci2005，，56： | 1 |
| 6 | Endometrial cancer side-population cel s show prominent migration and have a potential to differentiate into the mesenchymal cel lineage显示文摘 | Kato K Takao T Kuboyama A | | 0，，01： | 1 |
| 7 | Bulk damage caused by single protons in SDRAMs显示文摘 | SHINDOU H KUBOYAMA S IKEDA N | | 0，，06： | 1 |
| 8 | Cerebral cortex activity during supramaximal exhaustive exercise 显示文摘 | SHIBUYA K TANAKA J KUBOYAMA N | 2004 | J Sports Med Phys Fitness2004，44，2： | 1 |
| 9 | Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays显示文摘 | Tsuda M K Kuboyama KT Inoue T | | 0，，： | 1 |
| 10 | Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays显示文摘 | Tsuda M Kuboyama K Inoue T Nagata K Tozaki-Saitoh H Inoue K | 2009 | Mol Pain2009，5，： | 1 |
| 11 | Silk Fibroin-based Scaf-folds for Bone Regeneration 显示文摘 | Kuboyama N Kiba H Arai K | 2013 | J Biomed Mater Res B2013，101，2： | 1 |
| 12 | A spectrum tree kernel显示文摘 | Kuboyama T Hirata K Kashima H | 2007 | Information and Media Technologies2007，2，1： | 1 |
| 13 | Cerebral cortex activity during supramaximal exhaustive exercise显示文摘 | Shibuya K Tanaka J Kuboyama N | 2004 | J Sport Med Phys Fit2004，44，2： | 1 |
| 14 | A forest biornass yield table based on an empirical model 显示文摘 | Tomohiro Nishizono Toshio Iehara Hirofumi Kuboyama | 2005 | Journal of Forestry Research2005，10，： | 1 |
| 15 | Clinical feasibility of noncontrast-enhanced magnetic resonance lymphography of the thoracic duct显示文摘 | Takahashi H Kuboyama S Abe H | 2003 | Chest2003，124，6： | 1 |
| 16 | New global MCCB/ELCB G-twin breaker series 显示文摘 | KUBOYAMA K KOHANAWA A | 2006 | Fuji Electric Review2006，，52： | 1 |
| 17 | Astrocytic P2Y (1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral is- chemia显示文摘 | Kuboyama K Harada H Tozaki-Saitoh H | 2011 | J Cereb Blood Flow Metab2011，31，： | 1 |
| 18 | Search for natural products related to regeneration of the neuronal network 显示文摘 | Tohda C Kuboyama T Komatsu K | 2005 | Neurosignals2005，14，： | 1 |
| 19 | Protein tyrosine phosphatase receptor type Z negatively regulates oligodendrocyte differentiative and myelination 显示文摘 | KUBOYAMA K FUJIKAWA A MASUMURA M | 2012 | Plos One2012，7，48： | 1 |
| 20 | Mecha- nism for single-event burnout of bipolar transistors 显示文摘 | KUBOYAMA S SUZUKI T HIRAO T | 2000 | IEEE Transactions on Nuclear Science2000，47，6： | 1 |
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