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| 1 | IFN-a production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and-independent pathways显示文摘Understanding the defense mechanisms of the host of an organism is important for infection control.In previous studies,we demonstrated that interferon-a(IFN-a),but not IL-12,was produced by human peripheral blood mononuclear cells infected with varicella-zoster virus(VZV).Here,we investigated what kind of cell(s)and which signal molecule(s)are involved in IFN-a production.Using cell isolation and ELISA,we found that plasmacytoid dendritic cells(pDCs)were responsible for IFN-a production during VZV infection.We also found that Toll-like receptor 9(TLR9)was involved in VZV-induced IFN-a production because inhibitory CpG oligodeoxynucleotide inhibited IFN-a production.UV-inactivated VZV-induced IFN-a production was lower than that of active VZV,indicating another TLR9-independent pathway.Further studies demonstrated that double-stranded RNA-dependent protein kinase,but not DNA-dependent protein kinase was involved in VZV-induced IFN-a production.Together,these results suggest that pDCs play an important role in IFN-a production during VZV infection through TLR9-dependent and-independent pathways. | Hong-Ren Yu Hsin-Chun Huang Ho-Chang Kuo Jiunn-Ming Sheen Chia-Yo Ou Te-Yao Hsu Kuender D Yang | 2011 | Cellular & Molecular Immunology2011，8，2： | 7 |
| 2 | Recruitment of mesenchymal stem cells and expression of TGF-β1 and VEGF in the early stage of shock wave-promoted bone regeneration of segmental defect in rats显示文摘 | Yeung-Jen Chen Tilmann Wurtz Ching-Jen Wang Yur-Ren Kuo Kuender D Yang Hue-Chen Huang Feng-Sheng Wang | 2003 | Journal of Orthopaedic Research2003，，3： | 2 |
| 3 | Erosive esophagitis associated with metabolic syndrome,impaired liver function, and dyslipidemia显示文摘AIM:To investigate whether erosive esophagitis is correlated with metabolic syndrome and its components,abnormal liver function,and lipoprotein profiles.METHODS:We conducted a cross-sectional,case control study of subjects who underwent upper endoscopy during a health examination at the Health Management and Evaluation Center of a tertiary medical care facility located in Southern Taiwan.Metabolic syndrome components,body mass index(BMI),liver function,dyslipidemia,and cardiovascular risk factors,as defined by the ratio of total cholesterol to high-density lipoprotein cholesterol(HDL-C),and the ratio of low-density lipoprotein cholesterol to HDL-C were compared betweenindividuals with and without erosive esophagitis.Risk factors for erosive esophagitis were evaluated by multivariate logistic regression.RESULTS:Erosive esophagitis was diagnosed in 507of 5015 subjects who were individually age and sex matched to 507 esophagitis-free control subjects.In patients with erosive esophagitis,BMI,waist circumference,blood pressure,fasting plasma glucose,triglyceride levels,aspartate aminotransferase,alanine aminotransferase,the ratio of total cholesterol to HDL-C,and the ratio of low-density lipoprotein cholesterol to HDL-C were significantly higher and HDL-C was significantly lower compared to patients without erosive esophagitis(all P<0.05).In a multivariate analysis,central obesity(OR=1.38;95%CI:1.0-1.86),hypertension(OR=1.35;95%CI:1.04-1.76),hypertriglyceridemia(OR=1.34;95%CI:1.02-1.76),cardiovascular risk factors as defined by a ratio of total cholesterol to HDL-C>5(OR=1.45;95%CI:1.06-1.97),and aspartate aminotransferase(OR=1.59;95%CI:1.08-2.34)were significantly associated with erosive esophagitis.CONCLUSION:Metabolic syndrome,impaired liver function,and a higher ratio of total cholesterol to HDL-C were associated with erosive esophagitis. | Song-Seng Loke Kuender D Yang Kuang-Den Chen Jung-Fu Chen | 2013 | World Journal of Gastroenterology2013，19，35： | 2 |
| 4 | Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-β1 and IGF-I expression显示文摘 | Yeung-Jen Chen Ching-Jen Wang Kuender D Yang Yur-Ren Kuo Hui-Chen Huang Yu-Ting Huang Yi-Chih Sun Feng-Sheng Wang | 2003 | Journal of Orthopaedic Research2003，，4： | 1 |
| 5 | Sialylated glycansas receptor and inhibitor of enterovirus71infection to DLD-1in-testinal cells显示文摘 | Betsy Yang Hau Chuang Kuender D Yang | 2009 | Virology Journal2009，15，6： | 1 |
| 6 | Shock wave therapy induces neovascularization at the tendon–bone junction显示文摘 | Ching-Jen Wang Feng-Sheng Wang Kuender D Yang Lin-Hsiu Weng Chia-Chen Hsu Chun-Shun Huang Lin-Cheng Yang | 2003 | Journal of Orthopaedic Research2003，，6： | 1 |
| 7 | Shock wave therapy induces neovascularization at the tendon–bone junction显示文摘 | Ching-Jen Wang Feng-Sheng Wang Kuender D Yang Lin-Hsiu Weng Chia-Chen Hsu Chun-Shun Huang Lin-Cheng Yang | 2003 | Journal of Orthopaedic Research2003，，6： | 1 |
| 8 | Activation of extracellular signal-regulated kinase (ERK) and p38 kinase in shock wave-promoted bone formation of segmental defect in rats显示文摘 | Yeung-Jen Chen Yur-Ren Kuo Kuender D Yang Ching-Jen Wang Shyr-Ming Sheen Chen Hui-Chen Huang Ya-Ju Yang Sun Yi-Chih Feng-Sheng Wang | 2004 | Bone2004，，3： | 1 |
| 9 | Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-β1 and IGF-I expression显示文摘 | Yeung-Jen Chen Ching-Jen Wang Kuender D Yang Yur-Ren Kuo Hui-Chen Huang Yu-Ting Huang Yi-Chih Sun Feng-Sheng Wang | 2003 | Journal of Orthopaedic Research2003，，4： | 1 |
| 10 | Activation of extracellular signal-regulated kinase (ERK) and p38 kinase in shock wave-promoted bone formation of segmental defect in rats显示文摘 | Yeung-Jen Chen Yur-Ren Kuo Kuender D Yang Ching-Jen Wang Shyr-Ming Sheen Chen Hui-Chen Huang Ya-Ju Yang Sun Yi-Chih Feng-Sheng Wang | 2004 | Bone2004，，3： | 1 |
| 11 | Activation of extracellular signal-regulated kinase (ERK)and p38 kinase in shock wave-promoted bone formation of segmental defect in rats显示文摘 | Yeung-Jen Chen Yur-Ren Kuo Kuender D Yang | 2004 | Bone2004，34，3： | 1 |
| 12 | Activation of extracellular signal-regulated kinase(ERK) and p38 kinase in shock wave-promoted bone formation of segmental defect in rats显示文摘 | Yeung-Jen Chen Yur-Ren Kuo Kuender D | 2004 | Bone2004，34，3： | 1 |
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