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24篇 您的检索式：作者名="Kulbacka"

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	题名	作者	年代	出处	被引量
1	ETM study of electroporation influence on cell morphology in human malignant melanoma and human primary gingival fibroblast cells显示文摘Objective:To estimate electroporation(EP) influence on malignant and normal cells.Methods: Two cell lines including human malignant melanoma(Me-43) and normal human gingival fibroblast(HCFs) were used.EP parameters were the following:230,1000,1 730,2 300 V/cm;30 μ s by 3 impulses for every case.The viability of cells after EP was estimated by MTT assay. The ullrastructural analysis was observed by transmission electron microscope(Zeiss EM 900). Results:In the current study we observed the intracellular effect following EP on Me-43 and HGF cells.At the conditions applied,we did not observe any significant damage of mitochondrial activity in both cell lines treated by EP.Conversely,we showed that EP in some conditions can stimulate cells to proliferation.Some changes induced by EP were only visible in electron microscopy.In fibroblast cells we observed significant changes in lower parameters of EP(230 and 1 000 V/cm).After applying higher electric field intensities(2 300 V/cm) we detected many vacuoles,myelin-like bodies and swallowed endoplasmic reticulum.In melanoma cells such strong pathological modifications after EP were not observed,in comparison with control cells. The ultrastructure of both treated cell lines was changed according to the applied parameters of EP.Conclusions:We can claim that EP conditions are cell line dependent.In terms of the intracellular morphology,human fibroblasts are more sensitive to electric field as compared with melanoma cells.Optimal conditions should be determined for each cell line.Summarizing our study,we can conclude that EP is not an invasive method for human normal and malignant cells. This technique can be safely applied in chemotherapy for delivering drugs into tumor cells.	Nina Skolucka Malgorzata Daczewska Jolanta Saczko Agnieszka Chwilkowska Anna Choromanska Malgorzata Kotulska Iwona Kaminska Julita Kulbacka	2011	Asian Pacific Journal of Tropical Biomedicine2011，1，2：	2
2	Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus显示文摘	Schaefer-Graf UM Graf K Kulbacka I	2008	Diabetes Care2008，31，9：	1
3	Dynamic Oxidoreduc- tive Potential of Astringent Retraction Agents 显示文摘	Nowakowska D Saczko J Kulbacka J	2010	Folia Biol ( Pra- ha)2010，56，6：	1
4	Reactive oxygen and nitrogen species 显示文摘	Lugowski M Saczko J Kulbacka J	2011	Pol Merkur Lekarski2011，31，185：	1
5	Oxidative stress in cells damage processes显示文摘	Kulbacka J Saczko J Chwiikowska A	2009	Pol Merkur Lekarski2009，27，157：	1
6	Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells显示文摘	Drag-Zalesinska M Kulbacka J Saczko J	2009	Bioorg Med ChemLett2009，19，16：	1
7	The influence of electropo- ration on in vitro photodynamic therapy of human breast carcinoma cells 显示文摘	Kulbacka J Nowak M Skolucka N	2011	Folia Biol (Praha)2011，57，3：	1
8	Advances in photodynamic therapy assisted by electroporation显示文摘	Kotulska M Kulbacka J Saczko J	2013	Curr Drug Metab2013，14，3：	1
9	Cytotoxic potential of vasoconstrictor experimental gingival retraction agents: in vitro study on primary human gingival fibroblasts显示文摘	NOWAKOWSKA D SACZKO J KULBACKA J	2012	Folia Biol (Praha)2012，58，1：	1
10	Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus 显示文摘	Schaefer-Graf UM Graf K Kulbacka I	2008	Diabetes Care2008，31，9：	1
11	Anticancer properties of low molecular weight oat beta-glucan:An in vitro study显示文摘	Choromanska A Kulbacka J Rembialkowska N	2015	International Journal of Biological Macromolecules2015，80，：	1
12	Oxidative stress in cells damage processes显示文摘	Kulbacka J Saczko J Chwilkowska A	2009	Pol Merkur Lekarski2009，27，：	1
13	Photooxidative action in cancer and normal cells induced by the use of photofrin in photodynamic therapy显示文摘	Saczko J Chwilkowska A Kulbacka J	2008	Folia Biol(Praha)2008，54，1：	1
14	Photooxidative action in cancer and normal ceils induced by the use of Photofrin in photodynamic therapy 显示文摘	Saczko J Chwilkowska A Kulbacka J	2008	Folia Biol ( Praha)2008，54，：	1
15	Dynamic oxidoreductive potential of astringent retraction agents 显示文摘	Nowakowska D Saczko J Kulbacka J	2010	Folia Biol ( Praha)2010，56，6：	1
16	Cytotoxic po- tential of vasoconstrictor experimental gingival retraction a- gents: In vitro study on primary human gingival fibroblasts 显示文摘	Nowakowska D Saczko J Kulbacka J et al	2012	Folia Biol (Praha)2012，58，1：	1
17	Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus 显示文摘	Schaefer-Graf UM Graf K Kulbacka I	2008	Diabetes care2008，31，：	1
18	Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus显示文摘	Schaefer-graf UM Graf K Kulbacka I		0，，09：	1
19	Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus 显示文摘	Schaefer-graf UM Graf K Kulbacka I	2008	Diabetes care2008，31，9：	1
20	A simple and established method of tissue culture of human gingival fibroblasts for gingival augmentation显示文摘	Saczko Jolanta Dominiak Marzena Kulbacka Julita Chwilkowska Agnieszka Krawczykowska Honorata	2008	Folia Histochemica et Cytobiologica2008，，1：	1

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