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| 1 | Nested case-control study on the risk factors of colorectal cancer显示文摘AIM: To investigate the risk factors of colon cancer andrectal cancer.METHODS: A nested case-control study was conducted ina cohort of 64 693 subjects who participated in a colorectalcancer screening program from 1989 to 1998 in Jiashancounty, Zhejiang, China. 196 cases of colorectal cancer weredetected from 1990 to 1998 as the case group and 980non-colorectal cancer subjects, matched with factors of age,gender, resident location, were randomly selected from the64 693 cohort as controls. By using univariate analysis andmutivariate conditional logistic regression analysis, the oddsratio (OR) and its 95 % confidence interval (95 %CI) werecalculated between colorectal cancer and personal habits,dietary factors, as well as intestinal related symptoms.RESULTS: The mutivariate analysis results showed that aftermatched with age, sex and resident location, mucous bloodstool history and mixed sources of drinking water were closelyassociated with colon cancer and rectal cancer, OR values forthe mucous blood stool history were 3.508 (95 %CI: 1.370-8.985) and 2.139 (95 %CI: 1.040-4.402) respectively; for themixed drinking water sources, 2.387 (95 %CI: 1.243-4.587)and 1.951 (95 %CI: 1.086-3.506) respectively. All reachedthe significant level with a P-value less than 0.05.CONCLUSION: The study suggested that mucous bloodstool history and mixed sources of drinking water were therisk factors of colon cancer and rectal cancer. There was noany significant association between dietary habits and theincidence of colorectal cancer. | KunChen JianCai Xi-YongLiu Xi-YuanMa Kai-YanYao ShuZheng | 2003 | World Journal of Gastroenterology2003，9，1： | 15 |
| 2 | Relationship between metabolic enzyme polymorphism and colorectal cancer显示文摘AIM: To clarify the influence of genetic polymorphisms on colorectal cancer.METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data.RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)-rapid acetylator phenotype and genotye (pooled OR = 1.08)and NAT2-rapid acetylator phenotype (pooled OR = 1.15)had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYP1A1 L1e462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05).CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion,NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype. | KunChen Qin-TingJiang Han-QingHe | 2005 | World Journal of Gastroenterology2005，11，3： | 10 |
| 3 | Helicobacterpylori infection and gastric cancer:evidence from a retrospective cohort study and nested case-control study in China显示文摘AIM:To explore the association between Helicobacter pylri(HP) infection and risk of gastric cancer in China. | Bing-QuanWu TaoWang KunChen Ji-YaoWang Jie-PingZhang San-RenLi | 2002 | World Journal of Gastroenterology2002，8，6： | 8 |
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