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| 1 | Non-anthracycline-containing docetaxel and cyclophosphamide regimen is associated with sustained worse outcome compared with docetaxel, anthracycline and cyclophosphamide in neoadjuvant treatment of triple negative and HER2-positive breast cancer patients:显示文摘Objective: A previous study demonstrated that non-anthracycline-containing docetaxel plus cyclophosphamide(TC) regimen was inferior to docetaxel, anthracycline and cyclophosphamide(TAC) in neoadjuvant treatment of triple-negative breast cancer(TNBC) and human epidermal growth factor receptor-2-(HER2)-positive breast cancer in a short-term follow-up. Herein, long-term follow-up survival outcomes have been investigated.Methods: TNBC or HER2-positive patients were randomized to receive 6 cycles of TC or TAC neoadjuvant treatment. The primary endpoint was pathological complete remission(p CR). Secondary endpoints included clinical response rate, event-free survival(EFS), and overall survival(OS).Results: A cohort of 96 patients consisted of 45 in TC and 51 in TAC arm. With a median follow-up period of53(range, 8–76) months, the patients achieving p CR post neoadjuvant chemotherapy exhibited superior EFS and OS than patients without p CR(P<0.05). TAC treatment resulted in consistently better EFS than TC treatment:the estimated 5-year EFS was 66.1% vs. 29.8%(P=0.002). Moreover, the estimated 5-year OS was also in favor of TAC: 88.4% vs. 51.6%(P<0.001). Multivariable analysis demonstrated that the treatment regimen was an independent prognostic factor, and patients treated with TAC had a superior EFS [hazard ratio(HR), 0.48; 95%confidence interval(95% CI), 0.26–0.90; P=0.021] and OS(HR, 0.20; 95% CI, 0.08–0.60; P=0.003).Conclusions: The updated long-term follow-up data demonstrated a sustained benefit in EFS and OS from anthracycline-containing TAC treatment, indicating that anthracycline is an essential and effective drug in this clinical trial. | Xiaosong Chen Guolin Ye Chenfang Zhang Xinzheng Li Kunwei Shen | 2016 | Chinese Journal of Cancer Research2016，28，6： | 4 |
| 2 | Ultrasonic preparation of nano-nickel/activated carbon composite using spent electroless nickel plating bath and application in degradation of 2,6-dichlorophenol显示文摘Ni was effectively recovered from spent electroless nickel(EN) plating baths by forming a nano-nickel coated activated carbon composite. With the aid of ultrasonication, melamine–formaldehyde–tetraoxalyl-ethylenediamine chelating resins were grafted on activated carbon(MFT/AC). Pd Cl2 sol was adsorbed on MFT/AC, which was then immersed in spent electroless nickel plating bath; then nano-nickel could be reduced by ascorbic acid to form a nano-nickel coating on the activated carbon composite(Ni/AC) in situ. The materials present were carefully examined by Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, X-ray photoelectron spectroscopy and electrochemistry techniques. The resins were well distributed on the inside and outside surfaces of activated carbon with a size of 120 ± 30 nm in MFT/AC, and a great deal of nano-nickel particles were evenly deposited with a size of 3.8 ± 1.1 nm in Ni/MFT. Moreover, Ni/AC was successfully used as a catalyst for ultrasonic degradation of 2,6-dichlorophenol. | Jingyu Su Guanping Jin Changyong Li Xiaohui Zhu Yan Dou Yong Li Xin Wang Kunwei Wang Qianqian Gu | 2014 | Journal of Environmental Sciences2014，26，11： | 2 |
| 3 | Hydrothermal synthesis and photocatalytic properties of titanium acid H2Ti2O5(H2O) nanosheets显示文摘 | ZhiQiang Song HaiYan Xu KunWei Li | 2005 | Journal Molecular Catalysis A:Chemical2005，239，1： | 1 |
| 4 | Synthesis of CuS thin films by microwave assisted chemical bath deposition显示文摘 | Mudi Xin KunWei Li Hao Wang | 2009 | Applied Surface Science2009，256，： | 1 |
| 5 | High-performance visible-light-driven SnS2/SnO2 nanocomposite photocatalyst prepared via in situ hydrothermal oxidation of SnS2 nanoparticles 显示文摘 | ZHANG Yongcai Du Zhenni LI Kunwei | 2011 | Appl Mater Interfaces2011，3，5： | 1 |
| 6 | Self- assembly of hydroxyapatite nanostructures by microwave irradiation 显示文摘 | Jingbing Liu Kunwei Li Hao Wang | 2005 | Nanoteehnology2005，16，： | 1 |
| 7 | Hydrothermal synthesis and photocatalytic properties of layered La2Ti2O7 nanosheets显示文摘 | Li Kunwei Wang Yan Wang Hao | 2006 | Nanotechnology2006，17，19： | 1 |
| 8 | Syn- thesis of CuS thin films by microwave assis- ted chemical bath deposition 显示文摘 | Much Xin KunWei Li Hao Wang | | Applied Surface Science0，256，： | 1 |
| 9 | Preparation, characterization and photoeatalytic properties of nanoplate Bi2MoO6 catalysts 显示文摘 | HongHua Li ChaoYu Liu KunWei Li | 2008 | Materials Scence2008，43，： | 1 |
| 10 | Transformation process and photocatalytic activities of hydrothermally synthesized Zn2Sn O4 nanocrystals显示文摘 | ZENG JIA XIN MUDI LI KUNWEI | 2008 | J Phys Chem C2008，112，11： | 1 |
| 11 | Transformation process and photocatalytic activities of hydrothermally synthe- sized显示文摘 | ZENG Jia XIN Mu Di LI KunWei | 2008 | J Phys Chem C2008，112，： | 1 |
| 12 | Self-assembly of hydroxyapatite nanostructures by microwave irradiation 显示文摘 | Liu Jingbing Li Kunwei Wang Hao | 2005 | Nanotechnology2005，16，： | 1 |
| 13 | Synthesis of CuS thin films by microwave assisted chemical bath deposition显示文摘 | Mudi Xin KunWei Li Hao Wang | 2009 | Applied Surface Science2009，，5： | 1 |
| 14 | Hydrothermal preparation and photocatalytic properties of Y 2 Sn 2 O 7 nanocrystals显示文摘 | KunWei Li Hao Wang Hui Yan | 2006 | Journal of Molecular Catalysis A Chemical2006，，1： | 1 |
| 15 | Facile synthesis of ZnS nanostructured spheres and their photocatalytic properties 显示文摘 | Xiao Wu KunWei Li Hao Wang | 2009 | Journal of Alloys and Compounds2009，487，1： | 1 |
| 16 | Prognostic value of the 21-gene recurrence score in ER-positive,HER2-negative,node-positive breast cancer was similar in nodenegative diseases:a single-center study of 800 patients显示文摘Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer.This study aimed to evaluate the prognostic significance of the 21-gene recurrence score(RS)in Chinese patients with pN0-l,estrogen receptor-positive(ER+),human epidermal growth factor receptor 2-negative(HER2)breast cancer.Among 800 patients recruited between 2009 and 2016,the median RS was 24(0-69),with 27.4%,46.8%,and 25.9%patients classified into low-,intermediate-,and high-risk groups.Cox regression analysis demonstrated that the high-risk category was associated with significantly higher odds of invasive disease-free survival(IDFS)and distant disease-free survival(DDFS)events compared with the low-risk category(IDFS:HR=2.450,95%Cl 1.017-5.902,P=0.046;DDFS:HR=2.829,95%Cl 1.013-7.901,P=0.047).No significant association between RS category and overall survival(OS)was found(intermediate vs.low:HR=1.244,95%Cl 0.292-5.297,P=0.768;high vs.low:HR=2.933,95%Cl 0.759-11.327,P=0.119).RS,as a continuous variable,was a highly significant predictor for IDFS(HR=1.028,95%Cl 1.010-1.047,P=0.002),DDFS(HR=1.030,95%Cl 1.010-1.051,P=0.003),and OS(HR=1.034,95%Cl 1.007-1.063,P=0.014).Our findings suggested that RS may predict IDFS in Chinese patients with ER+/HER2 breast cancer with NO or N1 disease. | Jiayi Wu Weiqi Gao Xiaosong Chen Chunxiao Fei Lin Lin Weiguo Chen Ou Huang Siji Zhu Jianrong He Yafen Li Li Zhu Kunwei Shen | 2021 | Frontiers of Medicine2021，15，4： | 0 |
| 17 | A nomogram to predict adjuvant chemotherapy recommendation in breast cancer patients with intermediate recurrence score显示文摘Objective: The indication of adjuvant chemotherapy recommendation(ACR) in breast cancer patients with intermediate recurrence score(RS) is controversial. This study investigated the relationship between routine clinicopathological indicators and ACR, and established a nomogram for predicting the probability of ACR in this subset of patients.Methods: Data for a total of 504 consecutive patients with intermediate RS from January 2014 to December2016 were retrospectively reviewed. A nomogram was constructed using a multivariate logistic regression model based on data from a training set(378 cases) and validated in an independent validation set(126 cases). A Youdenderived cut-off value was assigned to the nomogram for accuracy evaluation.Results: The multivariate logistic regression analysis identified that age, histological grade, tumor size, lymph node(LN) status, molecular subtype, and RS were independent predictors of ACR. A nomogram based on these predictors performed well. The P value of the Hosmer-Lemeshow test for the prediction model was 0.286. The area under the curve(AUC) values were 0.905 [95% confidence interval(95% CI): 0.876–0.934] and 0.883(95%CI: 0.824–0.942) in the training and validation sets, respectively. The accuracies of the nomogram for ACR were84.4% in the training set and 82.1% in the validation set.Conclusions: We developed a nomogram to predict the probability of ACR in breast cancer patients with intermediate RS. This model may aid the individual risk assessment and guide treatment decisions in clinical practice. | Feilin Qu Xiaosong Chen Xiaochun Fei Lin Lin Weiqi Gao Yu Zong Jiayi Wu Ou Huang Jianrong He Li Zhu Weiguo Chen Yafen Li Kunwei Shen | 2018 | Chinese Journal of Cancer Research2018，30，2： | 0 |
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