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| 1 | Targeting the Wnt Signaling Pathway in Liver Fibrosis for Drug Options:An Update显示文摘morbidity and mortality for healthcare systems worldwide.It imparts an enormous economic burden to societies,making continuous research and informational updates about its pathogenesis and treatment crucial.This review′s focus is on the current knowledge about the Wnt signaling path-way,serving as an important pathway in liver fibrosis development and activation of hepatic stellate cells(HSCs).Two types of Wnt pathways are distinguished,namely the ß-catenin-dependent canonical and non-canonical Ca^(2+) or planar cell polarity(PCP)-dependent pathway.The dynamic balance of physiologically healthy liver and hepatocytes is disturbed by repeated liver injuries.Activation of theß-catenin Wnt pathway prevents the regeneration of hepatocytes by the replacement of extracellular matrix(ECM),leading to the appearance of scar tissue and the formation of regenerated nodular hepatocytes,lacking the original function of healthy hepatocytes.Therefore,liver function is reduced due to the severely advanced disease.Selective inhibition ofß-catenin inhibits inflammatory processes(since chemokines and pro-inflammatory cytokines are produced during Wnt activation),reduces growth of activated HSCs and reduces collagen synthesis and angiogenesis,thereby reducing the progression of liver fibrosis in vivo.While the canonical Wnt pathway is usually inactive in a physiologically healthy liver,it shows activity during cell regeneration or renewal and in certain pathophysiological conditions,such as liver diseases and cancer.Targeted blocking of some of the basic components of the Wnt path-way is a therapeutic approach.These include the frizzled transmembrane receptor(Fz)receptors using the secreted frizzled-related protein family(sFRP),Fz-coreceptors low-density LRP 5/6 through dickkopf-related protein 1(DKK1)or niclosamide,glycogen kinase-3 beta(GSK-3β)using SB-216763,cyclic-AMP response element-binding protein(CBP)using PRI-724 and ICG-001,the lymphoid enhancer binding factor(LEF)/T cell-specific transcription factor(TCF)system as well as Wnt inhibitory factor 1(WIF1)and miR-17-5p using pinostilbene hydrate(PSH).Significant progress has been made in inhibiting Wnt and thus stopping the progression of liver fibrosis by diminishing key components for its action.Comprehending the role of the Wnt signaling pathway in liver fibrosis may lead to discovery of novel targets in liver fibrosis therapeutic strategies’development. | Kristina Duspara Kristina Bojanic Josipa Ivanusic Pejic Lucija Kuna Tea Omanovic Kolaric Vjera Nincevic Robert Smolic Aleksandar Vcev Marija Glasnovic Ines Bilic Curcic Martina Smolic | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 2 | The N363S and I559N single nucleotide polymorphisms of the h-GR/NR3C1gene in patients with bronchial asthma显示文摘 | Micha? Panek Tadeusz Pietras Adam Antczak Artur Fabijan Marcelina Przem?cka Pawe? Górski Piotr Kuna Janusz Szemraj | 2012 | International Journal of Molecular Medicine2012，，1： | 2 |
| 3 | A randomized, double-blind trial of the effect of glucocorticoid, antileukotriene and bete-agonist treatment on IL-10 serum levels in children with asthma显示文摘 | Stelmach I Jerzynska J Kuna P | 2002 | Clin Exp Allergy2002，32，2： | 1 |
| 4 | Finite element techniques for dynamic crack analysis in piezoelectrics显示文摘 | ENDERLEIN M RICOEUR A KUNA M | 2005 | International Journal of Fracture2005，134，34： | 1 |
| 5 | Fracture mechanics of piezoelectric materi- als-Where are we right now? 显示文摘 | Kuna M | 2010 | Eng Fract Mech2010，77，： | 1 |
| 6 | A randomized, double-blind trial of the effect of antiasthma treatment on lung function in children with asthma 显示文摘 | Stelmach I Grzelewski T Bobrowska-Korzeniowska M Stelmach P Kuna P | 2007 | Pulm Pharmacol Therap2007，20，6： | 1 |
| 7 | Covariates of craving in actively drinking alcoholics显示文摘 | Chakravorty S Kuna ST Zaharakis N | 2010 | Am J Addict2010，19，5： | 1 |
| 8 | A randomized,double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum eosinophilic cationic protein(ECP),soluble interleukin 2 receptor(sIL-2R),IL-4,and soluble intercellular adhesion molecule 1(sICAM-1)in children with asthma显示文摘 | Stelmach I Jerzynska J Kuna P | 2002 | J Allergy Clin Immunol2002，109，2： | 1 |
| 9 | A randomized double-blind trial of the effect of treatment with montelukast on broncial hypersponsiveness and serum ECP, sIL-2R, IL-4 and sICAM-1 in children with asthma显示文摘 | Stelmach I Jerzynska I Kuna P | 2002 | J Allergy Clin Immunol2002，109，： | 1 |
| 10 | The role of heparin in al- lergic inflammation显示文摘 | Jerzyfiska J Stelmach I Kuna P | 2000 | Pol Merkur Lekarski2000，8，47： | 1 |
| 11 | Mutated citrullinated vimentin antibodies in rheumatoid arthritis 显示文摘 | KUNA AT | 2012 | Clin Chim Acta2012，413，12： | 1 |
| 12 | Einflus von silixonweichmachern auf griff undmechanische eigenschaften yon textilen flachengebilden 显示文摘 | BEREDER A RIEGEL D KUNA C | 1993 | Melliand Textilberichte1993，12，： | 1 |
| 13 | Heart mitochondria in rats submitted to chronic hypoxia 显示文摘 | Cervos Navarro J Kunas RC Sampaolo S | 1999 | Histol Histopathol1999，14，4： | 1 |
| 14 | Ultrasonographic differentiation of benign from malignant neck lymphadenopathy in thyroid cancer显示文摘 | Kuna SK Bracic I Tesic V | 2006 | J Ultrasound Med2006，25，12： | 1 |
| 15 | Determination of Deformation and Failure Properties of Ductile Materials by Means of the Small Punch Test and Neural Networks显示文摘 | ABENDROTH M KUNA M | 2003 | Computational Materials Science2003，28，34： | 1 |
| 16 | A randomized,double-blindtrial of the effect of treatment with montelukast onbronchial hyperreponsiveness and serum eosinophiliccationic protein(ECP),solouble interleukin 2 receptor (sIL-2R),IL-4,andsoluble intereclluiar adhesionmolecule 1 (sICAM-1) in ch显示文摘 | Stelmach I Jerzynska J Kuna P | | 0，，02： | 1 |
| 17 | Identification of Ductile Damage and Fracture Parameters from the Small Punch Test using Neural Networks显示文摘 | Martin Abendroth Meinhard Kuna | 2006 | Engineering Fracture Mechanics2006，73，6： | 1 |
| 18 | Fracture Mechanics of Piezoelectric Materials-where Are We Right Now显示文摘 | Kuna M | 2010 | Engineering Fracture Mechanics2010，77，2： | 1 |
| 19 | The irregularly irregular pattern of respiratory dyskinesia显示文摘 | Kuna ST Awan R | | 0，，： | 1 |
| 20 | Identification of ductile damage and fracture parameters from the small punch test using neural networks 显示文摘 | Abendroth M Kuna M | 2006 | Engineering Fracture Mechanics2006，73，6： | 1 |
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