|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma显示文摘AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study.All patients had chronic liver disease(CLD) due to infection with HCV.Thirty patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were enrolled.Possible associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 mo.RESULTS:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with HCC.Among patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/mL.Furthermore,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient prognosis.CONCLUSION:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in HCV-related HCC. | Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers显示文摘 | Katsuhiko Nosho Shoko Kure Natsumi Irahara Kaori Shima Yoshifumi Baba Donna Spiegelman Jeffrey A. Meyerhardt Edward L. Giovannucci Charles S. Fuchs Shuji Ogino | 2009 | Gastroenterology2009，，5： | 4 |
| 3 | Screening of SLC25A13 mutation in the Thai population显示文摘AIM:To determine the prevalence of SLC25A13 mutations in the Thai population.METHODS:A total of 1537 subjects representing the Thai population were screened for a novel pathologic allele p.Met1?(c.2T>C)and six previously known common SLC25A13 mutations:[Ⅰ](c.851_854delGTAT),[Ⅱ](g.IVS11+1G>A),[Ⅲ](c.1638_1660dup),[Ⅳ](p.S225X),[Ⅴ](IVS13+1G>A),and[XIX](g.IVS16ins3kb)using a newly developed TaqMan and established HybProbe assay,respectively.Sanger sequencing was employed for specimens showing an aberrant peak to confirm the targeted mutation as well as the unknown aberrant peaks detected.Frequencies of the mutations identified were compared in each region.Carrier frequency and disease prevalence of citrin deficiency caused by SCL25A13 mutations were estimated.RESULTS:p.Met1?was identified in the heterozygous state in 85 individuals,giving a carrier frequency of1/18,which suggests possible selective advantage of this variant.The question of p.Met1?homozygote lethality remains unanswered which may serve as an explanation as to why this homozygote has yet to be identified in patients/controls even with high allele frequency.The p.Met1?mutation has rarely been studied in populations other than Thai and Chinese;therefore,may have been overlooked.Development of the TaqMan assay in the present study would allow a simple,rapid,and cost-effective method for mass screening.Heterozygous mutations:[XIX]and[Ⅰ]were identified in 17 individuals,giving a carrier rate of 1/90 and a calculated homozygote rate of 1/33000.Two novel variants,g.IVS11+17C>G and c.1311C>T,of unknown clinical significance were identified at low frequency.CONCLUSION:This study highlighted the current underestimation of citrin deficiency and suggests the possible selective advantage of the p.Met1?allele. | Parith Wongkittichote Chonlaphat Sukasem Atsuo Kikuchi Wichai Aekplakorn Laran T Jensen Shigeo Kure Duangrurdee Wattanasirichaigoon | 2013 | World Journal of Gastroenterology2013，19，43： | 4 |
| 4 | Plasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first-line oxaliplatin-based treatment显示文摘 | J.B. Kjersem T. Ikdahl O.C. Lingjaerde T. Guren K.M. Tveit E.H. Kure | 2014 | Molecular Oncology2014，，1： | 4 |
| 5 | γ″Precipitate in Inconel 718显示文摘The γ'precipitate in Inconel 718 Ni-base superalloy has been investigated using TEM. Based on a calculation of diffraction pattern. the orientation relations between precipitates and matrix are given in detail. The influence of solution temperature on growth of γ' precipitates was investigated. and a γ' precipitate free area near δ phase was found. The coarsening behaviour of γ' precipitates during short time aging is | Jianhong HE (Dept. of Mater. Sci. and Eng., Tsinghua University, Beijing, 100084, China)S.Fukuyama and K. Yokogawa (Chugoku National Industrial Research Institute, Hiro-suehiro 2-2-2, Kure, Hiroshima, 737-01, Japan (To whom correspondence should be addres | 1994 | Journal of Materials Science & Technology1994，10，4： | 3 |
| 6 | Hydrologic impact of regional climate change for the snowfed and glacierfed river basins in the Republic of Tajikistan: hydrological response of flow to climate change显示文摘 | S. Kure S. Jang N. Ohara M. L. Kavvas Z. Q. Chen | 2013 | Hydrol Process2013，，26： | 2 |
| 7 | 状态监测——维修的最佳化显示文摘转向架状态监测为提高可靠性和安全性以及为实现低维修成本提供机会。在本文中,SKF公司的Fottfried Kure先生阐述如何使用状态监测工具和利用数据处理程序进行故障检测和避免机械故障的发生。 | Gottfried Kure 刘景宝 | 2010 | 国外内燃机车2010，，6： | 2 |
| 8 | Evidence of apoptosis cell death after focal cerebral ischemia显示文摘 | Tominaga T Kure S Narisawa K | | 0，，01： | 1 |
| 9 | Downward move- ment of syringe pumps reduces syringe output显示文摘 | Kern H Kuring A Redlich U | 2001 | Br J Anaesth2001，86，6： | 1 |
| 10 | Comparison of a technique using a new percutaneous osteosynthesis device with conventional open surgery for displaced patella fractures显示文摘 | Kose KC Kure I Maralcan G | 2007 | J Orthop Trauma2007，26，1： | 1 |
| 11 | Allelic and non-allelicheterogeneities in pyridoxine Dependen seizures revealed by ALDH7AI mutational analysis 显示文摘 | Kanno J Kure S Narisawa A | 2007 | Mol Genet Metab2007，91，4： | 1 |
| 12 | Transgenic expression of a dominant-negative connexin26 causes degeneration of the organ of Cord and non-syndromic deafness显示文摘 | Kudo T Kure S Ikeda K | 2003 | Hum Mol Genet2003，12，： | 1 |
| 13 | Poly- crystalline silicon 'slit nanowire' for possible quan- tum devices显示文摘 | WADA Y KURE T YOSHIMURA T | 1994 | Journal of Vacuum Science *Tech- nology B: Microelectronics and Nanometer Struc- tures1994，12，1： | 1 |
| 14 | Endonuclease activation following focal ischemic injury in the rat brain 显示文摘 | Kure S Narisawa K | 1993 | Brain Res1993，608，： | 1 |
| 15 | Inherited risk factors for deep venous thrombosis following total hip arthroplasty in Japanese patients: matched control study 显示文摘 | Kiyoshige Y Kure S Goto K | 2007 | Orthop Sci2007，12，2： | 1 |
| 16 | Evaluating effects of sewage sludge and household compost on soil physical, chemical and microbiological properties显示文摘 | Debosz K Petersen S O Kure L K | 2002 | ApplSoilEcol2002，，19： | 1 |
| 17 | Stage specific effects of the osmolarity of a culture medium on the development of parthenogenetic diploids in the pig显示文摘 | Nguyen V T Kure bayashi S Harayama H | 2003 | Theriogenology2003，59，34： | 1 |
| 18 | P16-positive continuous minimal deviation adenocarcinoma and gastric type adenocarcinoma in a patient with Peutz-Jeghers syndrome显示文摘 | Peng WX Kure S Ishino K | 2015 | Int J Clin Exp Pathol2015，8，5： | 1 |
| 19 | A Comparison of Load Balancing Techniques for Scalable Web Servers显示文摘 | Bryhni H Klovning E Kure O | 2000 | IEEE Network2000，7，8： | 1 |
| 20 | Tetrahydrobiopterln - responsive phenylalanine hydroxylase deficiency显示文摘 | S Kure DC Hou | 1999 | J Pediatr1999，135，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员