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| 1 | Lack of hepcidin expression attenuates steatosis and causesfibrosis in the liver显示文摘AIM: To investigate the role of key iron-regulatory protein, hepcidin in non-alcoholic fatty liver disease(NAFLD). METHODS: Hepcidin(Hamp1) knockout and floxed control mice were administered a high fat and high sucrose(HFS) or a regular control diet for 3 or 7 mo. Steatosis, triglycerides, fibrosis, protein and gene expression in mice livers were determined by histological and biochemical techniques, western blotting and realtime polymerase chain reaction. RESULTS: Knockout mice exhibited hepatic iron accumulation. Despite similar weight gains, HFS feeding induced hepatomegaly in floxed, but not knockout, mice. The livers of floxed mice exhibited higher levels of steatosis, triglycerides and c-Jun N-terminal kinase(JNK) phosphorylation than knockout mice. In contrast, a significant increase in fibrosis was observed in knockout mice livers within 3 mo of HFS administration. The hepatic gene expression levels of sterol regulatoryelement-binding protein-1c and fat-specific protein-27, but not peroxisome proliferator-activated receptoralpha or microsomal triglyceride transfer protein, were attenuated in HFS-fed knockout mice. Knockout mice fed with regular diet displayed increased carnitine palmitoyltransferase-1a and phosphoenolpyruvate carboxykinase-1 but decreased glucose-6-phosphatase expression in the liver. In summary, attenuated steatosis correlated with decreased expression of lipogenic and lipid storage genes, and JNK phosphorylation. Deletion of Hamp1 alleles per se modulated hepatic expression of beta-oxidation and gluconeogenic genes. CONCLUSION: Lack of hepcidin expression inhibits hepatic lipid accumulation and induces early development of fibrosis following high fat intake. Hepcidin and iron may play a role in the regulation of metabolic pathways in the liver, which has implications for NAFLD pathogenesis. | Sizhao Lu Robert G Bennett Kusum K Kharbanda Duygu Dee Harrison-Findik | 2016 | World Journal of Hepatology2016，8，4： | 3 |
| 2 | Transient focal ischemia induces motor deficit but does not impair the cognitive function in middle cerebral artery occlusion model of stroke in rats显示文摘 | Yogendra K G Kusum S Geeta C | 2002 | J Neuro Sci2002，203，204： | 1 |
| 3 | Simple construction of multiple interleavers: cyclically shifting a single interleaver 显示文摘 | KUSUME K BAUCH G | 2008 | IEEE Transactions on Communications2008，56，9： | 1 |
| 4 | Simple construction of multiple interleavers:cyclically shifting a single interleaver显示文摘 | KUSUME K BAUCH G | 2008 | IEEE Transactions on Communications2008，56，： | 1 |
| 5 | Simple Construction of Multiple Interleavers:Cyclically Shifting a Single Interleaver显示文摘 | KUSUME K BAUCH G | 2008 | TCOMM2008，56，09： | 1 |
| 6 | Tarsal contact chemoreceptors response to glucosinolates and cardenolides mediating oviposition in Pieris rapae 显示文摘 | Erich Stadler J A A Cella D Kusum S G | 1995 | Phys Ent1995，20，： | 1 |
| 7 | Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury显示文摘It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain. | Natalia A Osna Wayne G Carter Murali Ganesan Irina A Kirpich Craig J Mc Clain Dennis R Petersen Colin T Shearn Maria L Tomasi Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，27： | 1 |
| 8 | Detection of a case of cervical dysplasia with co-existent cervical tuberculosis by pap smear examination显示文摘 | Ankit S Madhur K Kusum G | 2014 | Indian J Cancer2014，51，3： | 1 |
| 9 | Transient focal ischemia induces motor deficit but does not impair the cognitive function in middle cerebral artery occlusion model of stroke in rats显示文摘 | Yogendra K G Kusum S Geeta C | 2002 | J Neuro Sci2002，203，204： | 1 |
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