|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 中文版Kutcher青少年抑郁量表测评青少年样本的效度与信度显示文摘目的:检验中文版Kutcher青少年抑郁量表(11项)(KADS-11)的效度、信度,确定其敏感度、特异度和划界值等,以期对中国青少年抑郁症状的筛查提供有用的工具。方法:选取黑龙江、辽宁、河北、河南、江西、湖南6个省和上海市的11-17岁中小学学生3180例,使用KADS-11和儿童抑郁量表(CDI)对全部样本进行抑郁症状的筛查,并由精神科医生对CDI≥19分的学生(435例)使用DSM-IV做抑郁症的诊断评估,1个月后从上海地区的样本随机抽取73例以同样的程序对KADS-11、CDI进行重测。结果:探索性因子分析结果显示KADS-11有2个因子,使用验证性因子分析检验,两因子模型适配度较好,并且优于单因子模型,KADS-11与CDI总分之间呈正相关(r=0.74,P〈0.01),经诊断的抑郁症组在KADS-11各条目及总分得分上均高于非抑郁症组(P〈0.001);KADS-11量表在受试者工作特征曲线(ROC)下的面积AUC=0.94,11个条目的 AUC值都在0.7-0.9之间,选取总分≥9分作为KADS-11的划界值,此时,敏感度为89%,特异度为90%;KADS-11的Cronbachα系数为0.84,奇偶分半相关系数为0.77(P〈0.01),间隔1个月的重测信度为0.77(P〈0.01)。结论:中文版Kutcher青少年抑郁量表(11项)具有良好的效度、信度,且对青少年抑郁症筛查的准确性较高,可以用于对我国青少年抑郁症状的筛查。 | 周慧鸣 郝楠 杜亚松 刘艳玉 隋雨彤 王艳华 崔亚男 钟秋平 焦秀娟 魏屹峰 KUTCHER Stanley | 2015 | 中国心理卫生杂志2015，29，6： | 23 |
| 2 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 3 | Control ,c*(HTe*cti{)n ,aml nxxlc]-ing of sei - up en-or ami organ molio 显示文摘 | Kutcher CJ’Magmis CS Licbel SA | 1995 | Semin liadiat Oncol1995，5，： | 1 |
| 4 | The use of a multi-leaf collimator for conformal radiotherapy of carcinomas of the prostate and nasopharynx 显示文摘 | LoSasso T Chui CS Kutcher GJ | 1993 | International Journal of Radiation Oncology Biology Physics1993，25，： | 1 |
| 5 | Three Dimensional conformal radiotherapy and dose escalation:where do we stand?显示文摘 | Leibel SA Kutcher GJ | 1998 | Semin Radiat Oncol1998，8，1： | 1 |
| 6 | Trends in vascular complications after diagnostic cardiac catheterization and percutaneous coronary intervention via the femoral artery, 1998 to 2007显示文摘 | Applegate R J Saerinty MT Kutcher MA | 2008 | JACC Cardiovase Interv2008，1，： | 1 |
| 7 | Natural History and Effect of Resuscitation Ratio on Coagulation After Trauma:A Prospective Cohort Study显示文摘 | Kutcher ME Kornblith LZ Vilardi RF | 2014 | Ann Surg2014，12，： | 1 |
| 8 | Characterization of platelet dysfunction after trauma显示文摘 | Kutcher ME Redick BJ McCreery RC | 2012 | J Trauma Acute Care Surg2012，73，1： | 1 |
| 9 | Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations显示文摘 | Kutcher GJ Burman C Brewster L | | 0，，01： | 1 |
| 10 | Trends in vascular complications after diagnostic cardiac catheterization and percutaneous coronary intervention via the femoral artery,1998 to 2007显示文摘 | Applegate RJ Sacrinty MT Kutcher MA | 2008 | J Am Coll Cardiol Intv2008，1，3： | 1 |
| 11 | The Pericyte:Cellular Regulator of Microvascular Blood Flow显示文摘 | Kutcher ME Herman IM | 2009 | Microvasc Res2009，77，3： | 1 |
| 12 | A paradigm shift in trauma resuscitation:evaluation of evolving massive transfusion practices显示文摘 | KUTCHER M E KORNBLITH L Z NARAYAN R | 2013 | JAMA Surg2013，148，： | 1 |
| 13 | Three Dimensional Conformal Radiotherapy and Escalation: Where do We Stand?显示文摘 | Zelefsky MJ Leibel SA Kutcher GJ | 1998 | Semin Radiat Oncol1998，8，2： | 1 |
| 14 | Characterization of platelet dysfunction after trauma显示文摘 | Kutcher ME Redick BJ McCreery RC | 2012 | J Trauma Acute Care Surg2012，73，1： | 1 |
| 15 | Vascular complications with newer generations of angioseal vascular closure devices显示文摘 | APPLEGATE RJ SACRINTY M KUTCHER MA | 2006 | J Interv Cardiol2006，19，1： | 1 |
| 16 | Improved dose distribution for 3D con{ormal boost treatments in carcinoma of nasopharynx显示文摘 | Leibel S A Kutcher G J Harrison L B | 1991 | Int J Radiat Oncol Biol Phys1991，20，4： | 1 |
| 17 | Fitting of normal tissue tolerance data to an analytic function显示文摘 | Burman C Kutcher GJ Emami B | 1991 | Int J Radiat Oncol Biol Phys1991，21，： | 1 |
| 18 | Fitting of normal tissue tolerance data to an analytic function显示文摘 | Burman C Kutcher GJ Emami B | 1991 | Int J Radiat Oncol Biol Phys1991，21，1： | 1 |
| 19 | Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations显示文摘 | Kutcher GJ Bruman C Brewster L | 1991 | Int J Radiat Oncol Biol Phys1991，21，： | 1 |
| 20 | Evidence review and clinical guidance for the use of Ziprasidone in Canada显示文摘 | Gardner DM Murphy AL Kutcher S | 2013 | Ann Gen Psychiatry2013，12，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员