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| 1 | Helicobacter pylori-associated immune thrombocytopenia:Clinical features and pathogenic mechanisms显示文摘Immune thrombocytopenia(ITP)is an autoimmune disease mediated by anti-platelet autoantibodies.There is growing evidence that the eradication of Helicobacter pylori(H.pylori)effectively increases platelet count in a considerable proportion of ITP patients infected with this bacterium.In the majority of ITP patients responding to H.pylori eradication therapy,the anti-platelet autoantibody response is completely resolved with no relapse for more than 7 years,indicating that the disease is cured.Therefore,adult patients with suspected ITP should be examined for H.pylori infection,and eradication therapy is recommended if the infection is present.Notably,however,the efficacy of H.pylori eradication therapy in ITP patients varies widely among countries,with a higher response rate in Japan compared with the United States and European countries other than Italy.The pathogenesis of H.pylori-associated ITP is still uncertain,although the mechanisms are known to involve multiple factors.H.pylori may modulate the Fcγ-receptor balance of monocytes/macrophages in favor of activating Fcγreceptors,and H.pylori components may mimic the molecular makeup of platelet antigens.Further studies of the pathogenic process of H.pyloriassociated ITP may be useful for the development of new therapeutic strategies for ITP. | Masataka Kuwana | 2014 | World Journal of Gastroenterology2014，20，3： | 19 |
| 2 | 皮肌炎/临床无肌病性皮肌炎患者血清中CADM-140抗体的检测和临床意义显示文摘目的对皮肌炎(DM)/临床无肌病性皮肌炎(CADM)患者进行CADM-140抗体检测,探讨CADM-140抗体与临床特征间的联系。方法采集38例DM(22例)/CADM(16例)患者血清,另外采集46例伴有肺间质病变的其他结缔组织病患者血清,包括8例多发性肌炎、15例系统性红斑狼疮、5例系统性硬化病、6例干燥综合征、6例混合性结缔组织病、6例特发性肺纤维化和5例正常对照者。以重组黑素瘤分化相关基因5(rMDA-5)为底物,通过ELISA检测患者血清中CADM-140抗体,比较CADM-140抗体阳性与阴性患者的临床特征。结果①16例CADM和22例DM患者血清CADM-140抗体阳性例数分别为7例和2例,CADM患者阳性率(43.8%)显著高于DM(9.1%)(P〈0.05),46例伴有肺问质病变的其他结缔组织病患者及5例正常人均阴性;②CADM-140抗体阳性患者皮肤溃疡和坏死的发生率为8/9,红细胞沉降率为(40.8±23.1)mm/1h,CADM-140抗体阴性组分别为6.9%和(22.5±16.8)mm/1h,两组比较,P〈0.01和〈0.05;CADM-140抗体阳性患者乳酸脱氢酶水平显著高于阴性组(分别为328.3±104.2和241.1±100.3IU/L,P〈0.05),而肌酸激酶显著低于阴性组(分别为156.3±260.8和1806.2±3737.1IU/L,P〈0.05);两组问抗核抗体阳性率和恶性肿瘤发生率的差异无统计学意义;③CADM-140抗体阳性患者不仅肺间质病变发生率显著高于阴性组(分别为9/9和48.3%,P〈0.01),而且急进型肺间质病变发生率也显著高于阴性组(分别为5/9和0,P〈0.05)。阳性组肺高分辨率CT评分(122.9±54.8)显著高于阴性组(70.0-4-59.8)(P〈0.05)。结论通过检测CADM-140抗体不仅可以判断DM/CADM是否合并肺间质病变,还可能是伴发急进型肺问质病变的血清学标记,动态观察血清CADM-140抗体水平也许有助于预测肺间质病变病程。 | 曹华 李霞 亢延卿 施若非 周敏 Masataka Kuwana 丁晓毅 郑捷 | 2011 | 中华皮肤科杂志2011，44，7： | 10 |
| 3 | 禽类原始生殖细胞的迁移能力显示文摘Blood samples were collected from chicken embryos at stage 11~15, and labeled with fluorescent dye PKH26. Primordial germ cells (PGCs) were then isolated from blood samples by nycodenz density gradient centrifugation. After PGCs were labeled and isolated, about 200 PGCs in one microliter were injected into the subgerminal cavity of quail blastoderm at stageⅩ. After 48 hours incubation, chicken PGCs were identified by fluorescent microscopy. Red fluorescence emitted from PKH26 labeled chicken PGCs was observed in the head, the heart and the developing gonadal anlage of quail embryos. The result suggests that chicken PGCs still keep migration ability after 56 hours. | 李赞东 李相芝 赵东风 Takashi KUWANA | 2003 | 动物学报2003，49，6： | 5 |
| 4 | CD4 + CD25 + Foxp3 + Regulatory T Cells in the Pathophysiology of Immune Thrombocytopenia显示文摘 | Tetsuya Nishimoto Masataka Kuwana | 2013 | Seminars in Hematology2013，，： | 4 |
| 5 | Derivation of multipotent progenitors from human circulating CD14 + monocytes显示文摘 | Noriyuki Seta Masataka Kuwana | 2010 | Experimental Hematology2010，，7： | 3 |
| 6 | Effects of a Helicobacter pylori eradication regimen on anti-platelet autoantibody response in infected and uninfected patients with idiopathic thrombocytopenic purpura 显示文摘 | Asahi A Kuwana M Suzuki H | 2006 | Haematologica2006，91，10： | 1 |
| 7 | Mathematical modelling of weld phenomena 3 显示文摘 | Kuwana T Kokawa H Saotome M | 1997 | The Institute of Materials1997，64，： | 1 |
| 8 | Clinical characteris- tics of Japanese patients with anti-PL-7 ( anti-threonyl-tRNA synthetase) autoantibodies 显示文摘 | Sato S Hirakata M Kuwana M | 2005 | Clin Exp Rheumatol2005，23，： | 1 |
| 9 | Expression and function of the Delta-1/Notch-2/Hes- 1 pathway during experimental acute kidney injury显示文摘 | Kobayashi T Terada Kuwana I4 | 2008 | Kidney Int2008，73，11： | 1 |
| 10 | CD4 + CD25 Foxp3 regulatory T cells in the pathophysiology of immune thrombocytopenia 显示文摘 | Nishimoto T Kuwana M | 2013 | Semin Hematol2013，50，1： | 1 |
| 11 | Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury显示文摘 | Kobayashi T Terada Y Kuwana H | 2008 | Kidney Int2008，73，11： | 1 |
| 12 | A neuronal mechanism of propofol- induced central respiratory depression in newborn rats显示文摘 | KASHIWAGI M OKADA Y KUWANA S | 2004 | Anesth Analg2004，99，1： | 1 |
| 13 | Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane显示文摘 | Kuwana T Mackey MR Perkins G | 2002 | Cell2002，111，3： | 1 |
| 14 | Bcl-2 family Proteins and the role of mitochondria in apoptosis显示文摘 | Kuwana T Newmeyer D D | 2003 | Curr Opin Cell Biol2003，15，4： | 1 |
| 15 | Reversible electrode reaction of cytochrome c 显示文摘 | Yeh P Kuwana T | 1977 | Chemistry Letters1977，10，： | 1 |
| 16 | Suppression of autoreactive T- cell response to glycoprotein Ⅱb/Ⅲa by blockade of CIM0/CD154 interaction : implications for treatment of immune thromboeytopenic purpura显示文摘 | Kuwana M Kawakami Y Ikeda Y | 2003 | Blood2003，101，2： | 1 |
| 17 | Migratory mechanisms of chick primordial germ cells toward gonadal anlage显示文摘 | Kuwana T Rogulska T | 1999 | Cellular and Molecular Biology1999，45，： | 1 |
| 18 | Effects of a Helicobacter pylori eradication regimen on anti-platelet autoantibody response in infected and uninfected patients with idiopathic thrombocytopenic purpura显示文摘 | Asahi N Kuwana M Suzuki H | 2006 | Haematologica2006，91，10： | 1 |
| 19 | Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis显示文摘 | Chipuk J E Kuwana T Bouchier-Hayes L | 2004 | Science2004，303，5660： | 1 |
| 20 | Cisplatin-induced macro- autophagy occurs prior to apoptosis in proximal tubules in vivo显示文摘 | Inoue K Kuwana H Shimamura Y | 2010 | Clin Exp Nephrol2010，14，2： | 1 |
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