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| 1 | Tailored eradication vs empirical bismuth-containing quadruple therapy for first-line Helicobacter pylori eradication: A comparative,open trial显示文摘BACKGROUND Few studies have compared the efficacy and safety profile of a tailored eradication(TR)strategy based on the presence of a 23S ribosomal RNA point mutation with those of empirical bismuth-based quadruple therapy(EBQT)for first-line eradication of Helicobacter pylori(H.pylori)in Korean patients.AIM To compare the efficacy and safety of a TR strategy and those of EBQT regimen as first-line eradication therapy for H.pylori.METHODS This is an open-label,comparative study in which we prospectively enrolled patients over 18 years of age with H.pylori infection and retrospectively reviewed their data.H.pylori-positive patients diagnosed by rapid urease test,Giemsa staining,or dual priming oligonucleotide polymerase chain reaction(DPO-PCR)were enrolled from May 2016 to September 2018 at Gil Medical Center.Patients with H.pylori infection received either a TR regimen or the EBQT regimen.In the tailored therapy group that underwent DPO-PCR testing,patients with A2142G and/or A2143G point mutations were treated with a bismuth-containing quadruple regimen.The eradication rate,patient-reported side effect rate,and H.pylori eradication success rate were evaluated and compared between the groups.RESULTS A total of 150 patients were assigned to the TR(n=50)or EBQT group(n=100).The first-line eradication rate of H.pylori did not differ between the groups(96.0%vs 95.7%,P=0.9).The rate of eradication-related side effects for TR was 12.0%,which differed significantly from that of EBQT(43.0%)for first-line treatment(P<0.001).CONCLUSION DPO-PCR-based TR for H.pylori eradication may be equally efficacious,with less treatment-related complications,compared to EBQT in Korea,where clarithromycin resistance is high. | Youn I Choi Jun Won Chung Dong Kyun Park Kyoung Oh Kim Kwang An Kwon Yoon Jae Kim Ja Young Seo | 2019 | World Journal of Gastroenterology2019，25，46： | 1 |
| 2 | Dynamic process of technology spillover: a transfer function approach显示文摘 | Kwang I H Chihiro W | 2002 | Technovation2002，，22： | 1 |
| 3 | Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis显示文摘 | LIU J CHEN I KWANG J | 2005 | J girol2005，79，82： | 1 |
| 4 | Structure and prop erties of biodegradable gluten/aliphatic polyester blends 显示文摘 | Sung W I In K J Kwang H L | 1999 | European Polymer Journal1999，，35： | 1 |
| 5 | Characterization of a previously uni-dentified viral protein in Porcine circovirus type 2 - infected cellsand its role in virus - induced apoptosis显示文摘 | LIU J CHEN I KWANG J | 2005 | J Virol2005，79，13： | 1 |
| 6 | All-fiber a- cousto-optic tunable notch filter with electronically controllable spectral profile 显示文摘 | KIM H S YUN S H KWANG I K | 1997 | Optics Letters1997，22，19： | 1 |
| 7 | Enhanced replicationof porcine reproductive and respiratory syndrome(PRRS)virus in homogeneous subpopulation of MA-104 cell line显示文摘 | Kim H S Kwang J Yoon I J | 1993 | Arch Virol1993，133，34： | 1 |
| 8 | Characterization of a previously uni- dentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis显示文摘 | Liu Jue Chen I Kwang J | 2005 | J Virol2005，79，： | 1 |
| 9 | Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis显示文摘 | Liu J Chela I Kwang J | 2005 | J Virol2005，79，13： | 1 |
| 10 | Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis 显示文摘 | Liu J Chen I Kwang J | 2005 | J Virol2005，79，： | 1 |
| 11 | Development and validation of real-time quantitative reverse transcriptase polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro 显示文摘 | Winer J Christopher Kwang SJ Shackel I | 1999 | Analytical Biochemistry1999，270，： | 1 |
| 12 | Face recognition using kernel princi-pal components analysis显示文摘 | Kwang I K Keechul J Hang J K | 2002 | IEEE Signal Processing Letters2002，9，2： | 1 |
| 13 | Support Vector Machines for texture classification显示文摘 | Kwang I Keechul J Hang J | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，11： | 1 |
| 14 | Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis 显示文摘 | LIU J CHEN I KWANG J | 2005 | J Virol2005，79，13： | 1 |
| 15 | Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis显示文摘 | Liu J Chen I Kwang J | | 0，，13： | 1 |
| 16 | Fingertip reconstruction using a volar flap based on the transverse pabnar branch of the digita! artery 显示文摘 | Kwang S K Sung I Y Kim D Y | 2001 | Ann Plast Surg2001，47，3： | 1 |
| 17 | Tailored eradication strategy vs concomitant therapy for Helicobacter pylori eradication treatment in Korean patients显示文摘BACKGROUND Antibiotic resistance to Helicobacter pylori(H.pylori)infection,which ultimately results in eradication failure,has been an emerging issue in the clinical field.Recently,to overcome this problem,an antibiotic sensitivity-based tailored therapy(TT)for H.pylori infection has received attention.AIM To investigate the efficacy and safety profiles of TT for H.pylori infection treatment compared to a non-bismuth quadruple therapy,concomitant therapy(CT)regimen.METHODS We included patients(>18 years)with an H.pylori infection and without a history of Helicobacter eradication who visited the Gil Medical Center between March 2016 and October 2020.After being randomly assigned to either the TT or CT treatment group in 1 to 1 manner,patient compliance,eradication success rate(ESR),and patient-reported side effects profiles were assessed and compared between the two groups.H.pylori infection was diagnosed using a rapid urease test,Giemsa stain,or dual priming oligonucleotide polymerase chain reaction(DPO-PCR).Tailored eradication strategy based through the presence of a 23S ribosomal RNA point mutation.For the TT group,a DPO-PCR test,which detected A2142G and/or A2143G point mutations,and a clarithromycin resistance test were performed.Patients in the clarithromycin-resistant group were treated with a bismuth-containing quadruple combination therapy,while those with sensitive results were treated with the standard triple regimen.RESULTS Of the 217 patients with a treatment naive H.pylori infection,110 patients[mean age:58.66±13.03,men,n=55(50%)]were treated with TT,and 107 patients[mean age:56.67±10.88,men,n=52(48.60%)]were treated with CT.The compliance(TT vs CT,100%vs 98.13%,P=0.30),and follow-up loss rates(8.18%vs 9.35%,P=0.95)were not significantly different between the groups.The ESR after treatment was also not statistically different between the groups(TT vs CT,82.73%vs 82.24%,P=0.95).However,the treatment-related and patient-reported side effects were significantly lower in the TT group than in the CT group(22.77%vs 50.52%,P<0.001).CONCLUSION The DPO-based TT regimen shows promising results in efficacy and safety profiles as a first-line Helicobacter eradication regimen in Korea,especially when physicians are confronted with increased antibiotic resistance rates. | Youn I Choi Jun-Won Chung Kyoung Oh Kim Kwang An Kwon Yoon Jae Kim Jung Ho Kim Ja Young Seo Dong Kyun Park | 2021 | World Journal of Gastroenterology2021，27，31： | 1 |
| 18 | Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis显示文摘 | Liu J Chen I Kwang J | 2005 | J Virol2005，79，13： | 1 |
| 19 | Characterization of a previously unidenti- fied viral protein in porcine circovirus type 2 infected cells and its role in virus induced apoptosis显示文摘 | Liu J Chen I Kwang J | 2005 | Journal of Virology2005，79，： | 1 |
| 20 | Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its pole in virus-induced apoptosis显示文摘 | Liu J Chen I Kwang J | 2005 | J Virol2005，79，13： | 1 |
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