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| 1 | Efficacy of small-volume simethicone given at least 30 min before gastroscopy显示文摘AIM To evaluate the efficacy of 5 m L simethicone solution in decreasing gastric foam if given at least 30 min before gastroscopy.METHODS This was a randomized, placebo controlled, endoscopist blinded study performed at Changi General Hospital. Patients were at least 21 years old, had no prior sur-gical resection of the upper gastrointestinal tract, and scheduled for elective diagnostic gastroscopies. The primary outcome was the total mucosal visibility score(TMVS) which was evaluated using Mc Nally score. The sample size was calculated to be 24 per group(SD 2.4, 80% power, P < 0.05, 2-sample t test). RESULTS Fifty-four patients were randomised to receive either simethicone [1 m L liquid simethicone(100 mg) in 5 m L of water] or placebo(5 m L of water) at least 30 min before their gastroscopy. Six accredited consultants conductedthe gastroscopy, and the interobserver agreement of scoring TMVS was good with a Kappa statistic of 0.73. The simethicone group had significantly better mean TMVS compared to placebo(5.78 ± SD 1.65 vs 8.89 ± SD 1.97, P < 0.001). The improvement was statistically significant for the duodenum and the gastric antrum, angularis, body, and fundus. Percent 51.9 of patients in the simethicone group had a TMVS of 4(no bubbles at all) to 5(only 1 area with minimal bubbles), while in the placebo group 3.7% of patients had TMVS of 4 or 5. The number needed to treat was 2.1 to avoid a TMVS of 6 and more. The simethicone group also had a significantly shorter procedure time with less volume of additional flushes required during gastroscopy to clear away obscuring gastric foam.CONCLUSION With a premedication time of at least 30 min, 5 m L simethicone can significantly decrease gastric foam, decrease the volume of additional flushes, and shorten gastroscopy time. | Mingjun Song Andrew Boon Eu Kwek Ngai Moh Law Jeannie Peng Lan Ong Jessica Yi-Lyn Tan Prem Harichander Thurairajah Daphne Shih Wen Ang Tiing Leong Ang | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 10 |
| 2 | Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis显示文摘BACKGROUND Proton pump inhibitors(PPIs)are widely prescribed,often without clear indications.There are conflicting data on its association with mortality risk and hepatic decompensation in cirrhotic patients.Furthermore,PPI users and PPI exposure in some studies have been poorly defined with many confounding factors.AIM To examine if PPI use increases mortality and hepatic decompensation and the impact of cumulative PPI dose exposure.METHODS Data from patients with decompensated liver cirrhosis were extracted from a hospital database between 2013 to 2017.PPI users were defined as cumulative defined daily dose(cDDD)≥28 within a landmark period,after hospitalisation for hepatic decompensation.Cox regression analysis for comparison was done after propensity score adjustment.Further risk of hepatic decompensation was analysed by Poisson regression.RESULTS Among 295 decompensated cirrhosis patients,238 were PPI users and 57 were non-users.PPI users had higher mortality compared to non-users[adjusted HR=2.10,(1.20-3.67);P=0.009].Longer PPI use with cDDD>90 was associated with higher mortality,compared to non-users[aHR=2.27,(1.10-5.14);P=0.038].PPI users had a higher incidence of hospitalization for hepatic decompensation[aRR=1.61,(1.30-2.11);P<0.001].CONCLUSION PPI use in decompensated cirrhosis is associated with increased risk of mortality and hepatic decompensation.Longer PPI exposure with cDDD>90 increases the risk of mortality. | Marianne Anastasia De Roza Lim Kai Jia Wen Kam Yiong Huak Chan Andrew Kwek Tiing Leong Ang John Chen Hsiang | 2019 | World Journal of Gastroenterology2019，25，33： | 6 |
| 3 | Effects of noisy quantum channels on one-qubit rotation gate显示文摘We investigate the effects of noisy quantum channels on the entanglement of cluster states and one way quantum computational gates.We take a basic model,the rotational gate about x axis based on the cluster state,in order to get the most essential effects of the paradigmatic noisy quantum channels.The entanglement of cluster states in the noisy channels and the fidelity between the rotated state without noisy channel and that with noisy channel are calculated. | XU GuoFu Kwek L.C TONG DianMin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，5： | 3 |
| 4 | Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome 显示文摘 | Lew TW Kwek TK Tai D | 2003 | JAMA2003，290，： | 2 |
| 5 | Ten‐day triple therapy versus sequential therapy versus concomitant therapy as first‐line treatment for H elicobacter pylori infection显示文摘 | Tiing Leong Ang Kwong Ming Fock Mingjun Song Daphne Ang Andrew Boon Eu Kwek Jeannie Ong Jessica Tan Eng Kiong Teo Subbiah Dhamodaran | 2015 | J Gastroenterol Hepatol2015，，7： | 2 |
| 6 | Education: professional and lay: student companion program improves knowledge and attitudes toward palliative care显示文摘 | Kwek K Vahl C Eland J | 2004 | J Pain2004，5，3： | 1 |
| 7 | Kinematic approach to the mixed state geometric phase in nonunitary evolu-tion显示文摘 | SjOvist E Kwek L C | 2004 | Phys Rev Lett2004，93，8： | 1 |
| 8 | Bures fidelity of squeezed thermal states显示文摘 | Wang Xiang-bin Oh C H Kwek L C | 1998 | Phys Rev1998，58，5： | 1 |
| 9 | Quantum roulette:an extended quantum strategy显示文摘 | KWEK L C OH C H | 2004 | Phys Lett A2004，277，： | 1 |
| 10 | Apoptosis inhibitor as a suppressor of tumor progression:expression of Bcl-2 eliminated selective advantages for p53-deficient cells in the tumor显示文摘 | Gurova KV Kwek SS Koman IE | 2002 | Cancer Biol Ther2002，1，1： | 1 |
| 11 | The in vitro effects of clonidine and dexmedetomidine on human myometrium显示文摘 | Sia AT Kwek K Yeo GS | 2005 | Int J Obstet Anesth2005，14，2： | 1 |
| 12 | Single - operator-cholangioscopy - guided laser lithotripsy in patients with diffi-cult biliary and pancreatic ductal stones ( with videos ) 显示文摘 | Maydeo A Kwek BE Bhandari S etal | 2011 | Gastrointest Endosc2011，74，6： | 1 |
| 13 | Functional analysis and intracellular localization of p53 modified by SUMO-1 显示文摘 | Kwek SS Derry J Tyner AL | 2001 | Oncogene2001，20，20： | 1 |
| 14 | Potentiating en- dogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF 显示文摘 | Fong L Kwek S S O'Brien S | 2009 | Cancer Res2009，69，2： | 1 |
| 15 | The in vitro effects of clonidine and dexmedetomidine on human myometrium显示文摘 | Sia AT Kwek K Yeo GS | 2005 | Int J Obstet Anesth2005，14，2： | 1 |
| 16 | Safer childbirth: avoiding medical interventions fornon-medical reasons显示文摘 | Chong YS Kwek KY | 2010 | The Lancet2010，375，9713： | 1 |
| 17 | Single-operator chol- angioscopy-guided laser lithotripsy in patients with difficult biliary and pancreatic ductal stones (with videos) 显示文摘 | Maydeo A Kwek BE Bhandari S | 2011 | Gastro-intest Endosc2011，74，6： | 1 |
| 18 | 查看详情显示文摘 | J L Chen C F Wu L C Kwek C H Oh and M L Ge | | 0，，03： | 1 |
| 19 | Cephalomedullary nail versus sliding hip screw for unstable intertrochanter- ic fractures in elderly patients显示文摘 | Chua IT Rajamoney GN Kwek EB | 2013 | J Orthop Surg (Hong Kong)2013，21，3： | 1 |
| 20 | Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1),placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy显示文摘 | Tagore S Kwek K | | 0，，06： | 1 |
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