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| 1 | T2期胆囊癌肿瘤位置和手术范围对预后的影响:一项国际多中心研究显示文摘T2期胆囊癌根据肿瘤位置不同,进一步细分为T2a(腹膜侧)或T2b期(肝脏侧)。既往有研究认为对于腹膜侧(T2a)肿瘤,在不影响预后的情况下可避免肝脏切除,但是目前仍然缺乏可靠的证据。为了探讨肿瘤位置对T2期胆囊癌的预后价值并明确手术切除的适当范围,该研究分析了韩国、日本、智利和美国的14家医院中937例接受胆囊癌手术患者的临床及病理资料。 | Kwon W Kim H Han Y 杨发才(编译) | 2020 | 中华医学杂志2020，100，39： | 21 |
| 2 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 3 | 显示文摘 | Ju H Y Kwon C Li Q | 1995 | Appl Phys Rev Lett1995，75，： | 2 |
| 4 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 5 | The preparation of exfoliated graphite by using microwaves 显示文摘 | KWON O CHOIR S PARK K KWON Y | 2003 | J Ind Eng Chem (Seoul Republic Korea)2003，9，6： | 1 |
| 6 | Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi:oxysterols block transport by binding to Insig显示文摘 | RADHAKRISHNAN A IKEDA Y KWON H J | 2007 | Proc Natl Acad Sci USA2007，104，： | 1 |
| 7 | Kinetics of monodisperse iron oxide nanocrystal formation by “heating-up” process 显示文摘 | Kwon S G Piao Y Z Park J | 2007 | J Am Chem Soc2007，129，12： | 1 |
| 8 | S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors 显示文摘 | Kwon M MacLeod TJ Zhang Y | 2005 | Front Biosci2005，234，10： | 1 |
| 9 | Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng显示文摘 | HAN J Y IN J G KWON Y S | 2010 | Phytochemistry2010，71，1： | 1 |
| 10 | A quantitative bioassay for Necrosis toxin from Pyrenophora tritici - repentis based on electrolyre leakage显示文摘 | Kwon C Y Rasmussen J B Francl L J | 1996 | Phytopathol1996，86，： | 1 |
| 11 | Development of one step reverse transcriptase polymerase chain reaction to detect duck hepatitis virus type l显示文摘 | Kim M C Kwon Y K Joh S J | 2007 | Avian Dis2007，51，2： | 1 |
| 12 | Over expression of CD24:association with invasiveness in urothelial carcinoma of bladder显示文摘 | Choi Y L Lee S H Kwon G Y | 2007 | Arch Pathol Lab Med2007，131，2： | 1 |
| 13 | Ovarian cancer durring pregnancy : clinical and pregnancy outcome 显示文摘 | Kwon Y Mok J Lira K | 2010 | J Korean Med Sci2010，25，2： | 1 |
| 14 | Laparoscopic management of bile duct and bowel injury during laparoscopic cholecystectomy显示文摘 | KWON AH INUI H KAMIYAMA Y | 2001 | World J Surg2001，25，： | 1 |
| 15 | Regulation of ILlheta-mediated MUC2 gene in NCI-H292 human airway epithelial cells显示文摘 | Kim Y D Kwon E J Raque G H | 2000 | Biochem Biophys Res Commum2000，274，5： | 1 |
| 16 | Development of one-step reverse transcriptase-polymerase chain reaction to detect duck hepatitis virus type 1 显示文摘 | KIM M C KWON Y K JOH S J | 2007 | Avian Dis2007，51，2： | 1 |
| 17 | Prevention of pleural effusion after hepatectomy using fibrinsealant 显示文摘 | Uetsuji S Komada Y Kwon AH | 1994 | Int Surg1994，79，2： | 1 |
| 18 | CPW-fed planar ultra wideband antenna having a frequency band notch function 显示文摘 | KIM Y KWON D H | 2004 | Electronics Letters2004，40，7： | 1 |
| 19 | Continuous- conduction-mode SEPIC converter with low reverse- recovery loss for power factor correction 显示文摘 | KWON J M CHOI W Y LEE J J | 2006 | Electric Power Applications2006，153，5： | 1 |
| 20 | High-performance, nano-structured LiMnPO4 synthesized via a polyol method 显示文摘 | WANG D Y BUQA H CROUZET M DEGHENGHI G DREZENT EXNAR I KWON N H MINERS J H POLETTO L GRATZEL M | 2009 | J Power Sources2009，189，1： | 1 |
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