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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | Rb-Sr dating of sphalerites from MVT ore deposits显示文摘 | Nakai S Halliday A N Kesler S E Jones H D Kyle J R Lane T E | 1993 | Geochimica et Cosmochimica Acta1993，57，： | 1 |
| 3 | pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines显示文摘 | Chen N Kyle DE Pasay C | 2003 | Antimicrob Agents Chemother2003，47，11： | 1 |
| 4 | Rb-Sr dating of sphalerites from Mississippi Valley (MVT) ore deposits显示文摘 | Nakai S Halliday A N Kesler S E Jones H D Kyle J R and Lane T E | | 0，，： | 1 |
| 5 | Global vascular expression of murine D34, a sialomucin-like endothelial ligand for L-selectin显示文摘 | Baumhueter S Dybdal N Kyle C | 1994 | Blood1994，84，： | 1 |
| 6 | White Island volcano, New Zealand carbon dioxide and sulfur dioxide emission rates and melt inclusion studies 显示文摘 | Wardell L J Kyle P R Dunbar N | 2001 | Chemical Geology2001，177，： | 1 |
| 7 | Nutrition support in critically ill chil- dren:Underdelivery of energy and protein compared with current recom- mendations 显示文摘 | Kyle UG Jaimon N Coss -Bu JA | 2012 | J Acad Nutr Diet2012，112，12： | 1 |
| 8 | BIO-MOS Opportunities for improving calf produc-tion显示文摘 | Kyle N | 2002 | Feed Compounder2002，，6： | 1 |
| 9 | Nutrition support in critical- ly ill children: underdelivery of energy and protein compared with current recommendations 显示文摘 | Kyle UG Jaimon N Coss -Bu JA | 2012 | J Acad Natr Diet2012，112，12： | 1 |
| 10 | Pfcrt allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium fdciparum isolates from the Philippines 显示文摘 | Chen N Kyle DE Pasay C eta/ | 2003 | Antimicrob Agents Chemother2003，47，11： | 1 |
| 11 | Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation显示文摘 | Michela N Graeme M Kyle N | 2004 | Circ Res2004，94，： | 1 |
| 12 | Myeloma kidney: improving clinical outcomes?显示文摘 | Haynes R Leung N Kyle R | 2012 | Adv Chronic Kidney Dis2012，19，5： | 1 |
| 13 | Waterborne and dietary hexavalent chromium exposure causes DNA-protein crosslink(DPX) formation in erythrocytes of largemouth bass(Micropterus salmoides)显示文摘 | KUYKENDALL J R KYLE L M MELLINGER K N | 2006 | Aquatic Toxicology2006，78，： | 1 |
| 14 | Jaggedl-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin显示文摘 | Kevin G Leong Kyle N | 2007 | J Exp Med2007，12，： | 1 |
| 15 | Precious metal mineralogy in porphyry-, skarn-,and replacement-type ore deposits of the Ertsberg(Gu- nung Bijih) distriet,Irian Jaya, Indonesia显示文摘 | Rubin J N Kyle J R | 1997 | Economic Geolo- gy1997，92，5： | 1 |
| 16 | Skarn Cu-Au orebodies of the Gunung Bijih (Ertsberg) district, Irian Jaya, Indonesia 显示文摘 | Mertig H J Rubin J N Kyle J R | 1994 | Journal of Geochemical Exploration1994，50，1： | 1 |
| 17 | Determination of pre-eruptive H2O, F and Cl contents of silicic magmas using melt inclusions: examples from Taupo volcanic center, New Zealand 显示文摘 | Dunbar N W Hervig R L Kyle P R | 1989 | Bull Volcanol1989，51，： | 1 |
| 18 | Genetic aberrations and survival in plasma cell leukemia 显示文摘 | TIEDEMANN R E GONZALEZ-PAZ N KYLE R A | 2008 | Leukemia2008，22，5： | 1 |
| 19 | Photoconductance and inverse photoconductance in films of functionalized metal nanoparticles 显示文摘 | HIDEYUKI N KYLE J M B BARTLOMIEJ K | 2009 | Nature2009，460，37： | 1 |
| 20 | Soil nutrients influence spatial distributions of tropical tree species显示文摘 | Robert J James WD Kyle EH Joseph BY Robert FS Matthew M Stephen PH Renato V Hugo N Martha V Robin BF | 2007 | Proceedings of the National Academy of Sciences of the United States of America2007，104，3： | 1 |
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