|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Conceptualizing EvolvingModels of Educational Development 显示文摘 | Kym F Gosling D Sorcinelli D | 2010 | New Directions for Higher Education2010，，122： | 1 |
| 2 | Remodeling of the plasma for sperm-egg recognition: proteins membrane in preparation roles of acrosomal显示文摘有卵的细胞外的矩阵的精子的相互作用,带 pellucida (ZP ) 是在男、女的配偶子之间的联合的第一个步骤。这个过程的分子的机制被学习过去的六十年了,结果获得了有趣、糊涂。在这篇文章,我们描述我们的最近的工作,它从以前的研究尝试问题的二根线到地址。首先,因为有众多的 ZP,有约束力的蛋白质由各种各样的研究人员报导了,这些蛋白质怎么在 sperm-ZP 一起行动相互作用吗?第二,很多 acrosomal 蛋白质为什么有 ZP 亲密关系?他们主要涉及起始的 sperm-ZP 绑定或相当在抛锚的 acrosome 反应 / 反应精子到 ZP 吗?我们的研究揭示那很多 ZP 有约束力的蛋白质和女伴,从前面的精子头血浆膜提取了,作为高分子的重量(HMW ) 共存建筑群,和那在使能够的精子的这些建筑群有优先的能力绑在 ZP。Zonadhesin (ZAN ) ,与 ZP 亲密关系作为 acrosomal 蛋白质知道,是在 HMW 建筑群的这些蛋白质之一。Immunoprecipitation 显示 ZAN 与另外的 acrosomal 蛋白质, proacrosin/acrosin 和 sp32 (ACRBP ) 交往,在 HMW 建筑群也在场。精子上的 ZAN 和 proacrosin/acrosin 的 Immunodetection 进一步显示到精子头的两蛋白质交通在精子 acrosomal 矩阵仍然是未经触动的 capacitation 期间出现,并且因此,他们多半涉及起始的 sperm-ZP 绑定步。 | Nongnuj Tanphaichitr Kessiri Kongmanas Hathairat Kruevaisayawan Arpornrad Saewu Clarissa Sugeng Jason Fernandes Puneet Souda Jonathan B Angel Kym F Faull R John Aitken Julian Whitelegge Daniel Hardy Trish Berger Mark Baker | 2015 | Asian Journal of Andrology2015，17，4： | 0 |
| 3 | Antimicrobial lipids:Emerging effector molecules of innate host defense显示文摘The antimicrobial properties of host derived lipids have become increasingly recognized and evidence is mounting that antimicrobial lipids(AMLs),like antimicrobial peptides,are effector molecules of the innate immune system and are regulated by its conserved pathways.This review,with primary focus on the human body,provides some background on the biochemistry of lipids,summarizes their biological functions,expands on their antimicrobial properties and site-specific composition,presents modes of synergism with antimicrobial peptides,and highlights the more recent reports on the regulation of AML production as well as bacterial resistance mechanisms.Based on extant data a concept of innate epithelial defense is proposed where epithelial cells,in response to microbial products and proinflammatory cytokines and through activation of conserved innate signaling pathways,increase their lipid uptake and up-regulate transcription of enzymes involved in lipid biosynthesis,and induce transcription of antimicrobial peptides as well as cytokines and chemokines.The subsequently secreted antimicrobial peptides and lipids then attack and eliminate the invader,assisted by or in synergism with other antimicrobial molecules delivered by other defense cells that have been recruited to the site of infection,in most of the cases.This review invites reconsideration ofthe interpretation of cholesteryl ester accumulation in macrophage lipid droplets in response to infection as a solely proinflammatory event,and proposes a direct antimicrobial role of lipid droplet-associated cholesteryl esters.Finally,for the interested,but new-to-the-field investigator some starting points for the characterization of AMLs are provided.Before it is possible to utilize AMLs for anti-infectious therapeutic and prophylactic approaches,we need to better understand pathogen responses to these lipids and their role in the pathogenesis of chronic infectious disease. | Edith Porter Daniel C Ma Sandy Alvarez Kym F Faull | 2015 | World Journal of Immunology2015，5，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员