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| 1 | Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility显示文摘The azoospermia factor(AZF)region is important for spermatogenesis,and deletions within these regions are a common cause of oligozoospermia and azoospermia.Although several studies have reported this cause,the present research,to the best of our knowledge,is the first large-scale study assessing this factor in Japan.In this study,1030 male patients with infertility who were examined for Y chromosome microdeletion using the polymerase chain reaction-reverse sequence-specific oligonucleotide(PCR-rSSO)method,a newly developed method for Y chromosome microdeletion screening,were included.The study enrolled 250 patients with severe oligospermia and 717 patients with azoospermia.Among the 1030 patients,4,4,10,and 52 had AZFa,AZFb,AZFb+c,and AZFc deletions,respectively.The sperm recovery rate(SRR)of microdissection testicular sperm extraction in patients with AZFc deletions was significantly higher than that in those without AZF deletions(60.0%vs 28.7%,P=0.04).In patients with gr/gr deletion,SRR was 18.7%,which was lower than that in those without gr/gr deletion,but was not statistically significant.In conclusion,our study showed that the frequency of Y chromosome microdeletion in male patients in Japan was similar to that reported in patients from other countries,and SRR was higher in patients with AZFc deletion. | Masashi Iijima Kazuyoshi Shigehara Hideki Igarashi Koichi Kyono Yasuo Suzuki Yuji Tsuji Yoshitomo Kobori Hideyuki Kobayashi Atsushi Mizokami | 2020 | Asian Journal of Andrology2020，22，4： | 4 |
| 2 | Crystal Structures of Human Dipeptidyl Peptidase Ⅳ in its Apo and Diprotin B-complexed Forms显示文摘Dipeptidyl 肽酶 IV (DPPIV ) 丝氨酸朊酶 oligopeptidasefamily 属于 prolyl,被知道把许多规章的生物功能和过时的人或物显示在类型 2 糖尿病被含有。开发选择 humanDPPIV (hDPPIV ) 禁止者因此是重要的。在这研究,我们在 1.9A 分辨率决定了 apo hDPPIV 的水晶结构。我们 apo hDPPIV 的高分辨率的水晶结构在活性部位揭示了钠离子和甘油分子的存在。以便阐明 hDPPIV 绑定模式和底层特性,我们在 2.1 一分辨率决定了 hDPPIV-diprotin B (Val-Pro-Leu ) 建筑群的水晶结构,并且在在 diprotin B anddiprotin A (Ile-Pro-Ile ) 之间的有约束力的模式澄清了差别进 hDPPIV 的活性部位。在我们的水晶结构和报导 apo hDPPIV 结构之间的比较表明那断然为功能的组充电了并且保存了贡献的水分子有 hDPPIV 的 ligands 的相互作用。这些结果为有势力 hDPPIV 禁止者的设计是有用的。 | Hajime H1RAMATSU Kiyoshi KYONO Atsushi YAMAMOTO Kazuhiko SAEKI Hideaki SHIMA Shigeru SUGIYAMA Koji INAKA Ryo SHIMIZU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，5： | 4 |
| 3 | The crystal structure of TlAlSiO4: the role of inert pairs in exclusion of Tl from silicate minerals显示文摘 | Atsushi Kyono Mitsuyoshi Kimata Masahiro Shimizu | 2000 | American Mineralogist2000，85，： | 1 |
| 4 | Effect of additions of Ti, B and Ce on microstructural stability, creep strength and creep damage in austenitic stainless steel 显示文摘 | Laha K Kyono J Sasaki T | 2005 | Materials Science and Technology2005，21，11： | 1 |
| 5 | Potential indications-for ovarian autotransplantation based on the analysis of 5571 autopsyfinding of females under the age of 40 in Ja-pan显示文摘 | Kyono K Doshida M Toya M | | 0，，7： | 1 |
| 6 | Beneficial effect of B segregation on creep cavitation in a type 347 austenitic stainless steel 显示文摘 | Laha K Kyono J Kishimoto S | 2005 | Scripta Materialia2005，52，7： | 1 |
| 7 | An advanced creep cavitation resistance Cu-containing 18Cr-12Ni-Nb austenitic stainless steel 显示文摘 | Laha K Kyono J Shinya N | 2007 | Scripta Materialia2007，56，10： | 1 |
| 8 | Improved creep strength and creep ductility of type 347 austenitic stainless steel through the self-healing effect of boron for creep cavitation 显示文摘 | Laha K Kyono J Sasaki T | 2005 | Metallurgical and Materials Transactions A2005，36，2： | 1 |
| 9 | Clinical results of fetalobstructive uropathy treated by vesicoamniotic shunting 显示文摘 | Makino Y Kobayashi H Kyono K | 2000 | Urology2000，55，1： | 1 |
| 10 | Benificial Effect of B Segregation on Creep Cavitation in a Type 347 Austenite Stainless Steel显示文摘 | LaHa K Kyono J Kishimoto S | 2005 | Scripta Materialia2005，52，7： | 1 |
| 11 | Improved Creep Strength and Creep Ductility of Type 347 Austenitic Stainless Steel Through the Self-Healing Effect of Boron for Creep Cavitation 显示文摘 | LaHa K Kyono J Sasaki T | 2005 | Metallurgical and Materials Transactions2005，36，2： | 1 |
| 12 | The effect of isothermal exposure on the transverse properties of a continuous fiber metal-matrix composite显示文摘 | KYONO T HALL I W TAYA M | 1986 | Journal of Materials Science1986，21，12： | 1 |
| 13 | Vitamin D receptor agonist supplementation and suppression of inflammation may have ad- vantage for all - cause mortality in hemodialysis patients 显示文摘 | Ogawa T Kyono A Sato M | 2012 | Clinical and experimental nephrology2012，16，5： | 1 |
| 14 | Conversion of unused heat energy to electricity by means of thermoelectric generation in condenser显示文摘 | Kyono T Suzuki R O Ono K | 2003 | IEEE Transactions on Energy Conversion2003，18，1： | 1 |
| 15 | Nonlinear Proximal Decomposition Method for Convex Programming显示文摘 | M. Kyono M. Fukushima | 2000 | Journal of Optimization Theory and Applications2000，，2： | 1 |
| 16 | A study of histopathological assessment criteria for assessing malignancy of gastrointestinal stromal tumor,from a clinical standpoint显示文摘 | Kimiyoshi Yokoil Noritake Tanakal Kyono Shojil | 2005 | J Gastroenterol2005，40，： | 1 |
| 17 | Benifitial effect of B segregation on creep cavitation in a type 347 austenite stainless steel 显示文摘 | Laha K Kyono J Kishimoto S Shinya N | 2005 | Scripta Materialia2005，，52： | 1 |
| 18 | Creep fracture mechanism map and creep damage of Cr-Mo-V turbine rotor steel显示文摘 | SHINYA N KYONO J KUSHIMA H | | 0，，10： | 1 |
| 19 | Improved creep strength and creep ductility of type 347 austenitic stainless steel through the self-healing effect of boron for creep cavitation 显示文摘 | Laha K Kyono J Sasaki T Kishinoto S Shinya N | 2005 | Metallurgical and Materials Transactions A2005，36，2： | 1 |
| 20 | A second case of somatic triple mosaicism in the CYBB gene causing chronic granulomatous disease显示文摘 | Noack D Heyworth PG Kyono W | 2001 | Hum Genet2001，109，2： | 1 |
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