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| 1 | Different characteristics of chronic dibutyltin dichloride-induced pancreatitis and cholangitis in mouse and rat显示文摘Background:Current animal models of chronic pancreatitis(CP)often provide only limited pathophysio-logical insights since they incompletely reflect the human disease.CP induced by injection of dibutyltin dichloride(DBTC-pancreatitis)shares with human CP the important feature of extended fibrosis and would be an even more attractive model if it could be transferred from rats to mice,as recently sug-gested in the context of combined ethanol and DBTC application.This study aimed to evaluate the effects of DBTC in pancreas and liver of C57BL/6 mice,a strain commonly used to engineer genetic mouse mod-els.Methods:C57BL/6 mice and Lewis rats were exposed to variable doses of DBTC.After an investigation period of up to 4 weeks,laboratory findings and histopathological changes of pancreas and liver were evaluated.Results:Chronic DBTC-pancreatitis in rats was characterized by acinar cell damage,ductal changes,fi-brosis,and inflammatory cell infiltrates.Mice treated with DBTC at 6–8 mg/kg body weight,the standard doses in rats,showed transient increases of lipase activities but no morphological signs of chronic DBTC-pancreatitis 4 weeks after injection of the drug.Increased doses of 10–12 mg/kg DBTC were intolerable due to their high toxicity.In contrast,mice and rats presented with a similar histopathology of the liver that can be characterized as a chronic-proliferative DBTC-cholangitis with predominating damage and proliferation of the small bile ducts as well as secondary portal inflammatory cell infiltrates and a begin-ning portal fibrosis.Conclusions:The DBTC-model cannot be transferred from rats to C57BL/6 mice with respect to chronic DBTC-pancreatitis,but might be of interest to study DBTC-cholangitis in both species. | Friederike Lütt Luise Ehlers Horst Nizze Robert Jaster | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 2 |
| 2 | Gene expression:RNA interference in adult mice显示文摘 | McCaffrey AP Meuse L Pham TT | 2002 | Nature2002，418，： | 1 |
| 3 | Peptide aggregation and pore formation in a lipid bilayer:a combined coarse-grained and all atom molecular dynamics study显示文摘 | Th(o)gersen L Schi(o)tt B Vosegaard T | | 0，，09： | 1 |
| 4 | Racl signalling towardsGLUT4/glucose uptake in skeletal muscle 显示文摘 | Chiu TT Jensen TE Sylow L | 2011 | Cell Signal2011，23，10： | 1 |
| 5 | Ocular surface disease in posttra- beculectomy/mitomycin C patients 显示文摘 | L AM J WONG TT TONG L | 2015 | Clin Ophthalmol2015，9，1： | 1 |
| 6 | A randomized clinical trial of progressive addition lenses versus single vision lenses on the progression of myopia in chil-dren显示文摘 | Gwiazda J Hyman L Hussein M Everett D Norton TT Kurtz D | 2003 | Invest Ophthalmol Vis Sciy2003，44，4： | 1 |
| 7 | Annual performance of building-integrated photovoltaic/water- heating system for warm climate application 显示文摘 | CHOW TT CHAN A L S FONG K F | 2009 | Applied Energy2009，86，9： | 1 |
| 8 | Fluorescent gold nanoprobes for the sensitive and selective detection for Hg~ 显示文摘 | Chai F Wang TT Li L | 2010 | Nanoscale Res Lett2010，5，11： | 1 |
| 9 | Overexpression of G pro-tein-coupled receptor kinase-2 in smooth muscle cells reducesneointimal hyperplasia显示文摘 | Peppel K Zhang L Huynh TT | 2002 | J Mol Cell Cardiol2002，34，10： | 1 |
| 10 | Genetic basis for in vivo daptomycin resistance in enterococci显示文摘 | Arias CA Panesso D McGrath DM Qin X Mojica MF Miller C Diaz L Tran TT Rincon S Barbu EM Reyes J Roh JH Lobos E Sodergren E Pasqualini R Arap W Quinn JP Shamoo Y Murray BE Weinstock GM | | 0，，： | 1 |
| 11 | Dual role of interleukin-10in the regulation of respiratory syncitial virus(RSV)-induced lung inflammation显示文摘 | Sun L Cornell TT LeVine A | 2013 | Clin Exp Immunol2013，172，2： | 1 |
| 12 | Control parameterization enhancing technique for time optimal control problems 显示文摘 | LEE tt W J TEO K L REHBOCK V ct al | 1997 | Dynamic Systems and Applications1997，6，： | 1 |
| 13 | Use of recombinant nucleocapsid proteins of the hantaan and nephropathia epidemica serotypes of hantaviruses as immunodiagnostic antigens显示文摘 | Zōller L Yang S Gōtt P | 1993 | Journal of Medical Virology1993，39，2： | 1 |
| 14 | Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum显示文摘 | Tu L Sun TT Kreibich G | 2002 | Mol Biol Cell2002，13，12： | 1 |
| 15 | A highly sensitiveassay for spectrofluorimetric determination of reduced glutathione using organic nano-probes 显示文摘 | Wang LY Wang L Xia TT | 2005 | Spectrochim Acta Part A2005，61，： | 1 |
| 16 | Propranolol therapy to treat proble- matic lemangiomas: A new standard therapy nmkes its debut显示文摘 | l oftler H Kosel C Cremer tt el al | 2009 | Hau- tarzt2009，60，12： | 1 |
| 17 | Chining of human thymic stmmal lymphopoietin(TSLP) and signaling mechanisms leading to proliikq'a/ion 显示文摘 | Quentmeicr tt l)rexler HG Fleckenslein I) c! al | 2001 | Leukemia2001，15，8： | 1 |
| 18 | NG, a novelPABA/NO- based oleanolic acid derivative, induces Human hepatoma cell apoptosis via a ROS/MAPK - dependent mitochondrial pathway 显示文摘 | LIU L J FU J J LI TT | 2012 | European Journal of Pharmacology2012，691，13： | 1 |
| 19 | P1aning and simulation of neurosurgery in a virtual reality environment显示文摘 | Kockro RA Serra L Yeo TT | 2000 | Neurosurgery2000，46，1： | 1 |
| 20 | Optimal production ~ff polyhydroxyalkanoates (PHA) in activated sludge fed by volatile fatty acids (VFAs) generated from alkaline excess sludge fermentation 显示文摘 | Cai M M Chua tt Zhao Q L | 2009 | Bioresour Technol2009，100，3： | 1 |
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