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| 1 | Oxidative stress indicators as selection tools for salt tolerance显示文摘 | C.Luna L.Garcia‐Seffino C.Arias E.Taleisnik | 2008 | Plant Breeding2008，，4： | 1 |
| 2 | Time step truncation error indirect simulation Monte Carlo显示文摘 | ALEJANDRO L.GARCIA | | 0，，10： | 1 |
| 3 | Development of gemcitabine-resistant patient-derived xenograft models of pancreatic ductal adenocarcinoma显示文摘Aim:Gemcitabine is a frontline agent for locally-advanced and metastatic pancreatic ductal adenocarcinoma(PDAC),but neither gemcitabine alone nor in combination produces durable remissions of this tumor type.We developed three PDAC patient-derived xenograft(PDX)models with gemcitabine resistance(gemR)acquired in vivo,with which to identify mechanisms of resistance relevant to drug exposure in vivo and to evaluate novel therapies.Methods:Mice bearing independently-derived PDXs received 100 mg/kg gemcitabine once or twice weekly.Tumors initially responded,but regrew on treatment and were designated gemR.We used immunohistochemistry to compare expression of proteins previously associated with gemcitabine resistance[ribonucleotide reductase subunit M1(RRM1),RRM2,human concentrative nucleoside transporter 1(hCNT1),human equilibrative nucleoside transporter 1(hENT1),cytidine deaminase(CDA),and deoxycytidine kinase(dCK)]in gemR and respective gemcitabine-naïve parental tumors.Results:Parental and gemR tumors did not differ in tumor cell morphology,amount of tumor-associated stroma,or expression of stem cell markers.No consistent pattern of expression of the six gemR marker proteins was observed among the models.Increases in RRM1 and CDA were consistent with in vitro-derived gemR models.However,rather than the expected decreases of hCNT1,hENT1,and dCK,gemR tumors expressed no change in or higher levels of these gemR marker proteins than parental tumors.Conclusion:These models are the first PDAC PDX models with gemcitabine resistance acquired in vivo.The data indicate that mechanisms identified in models with resistance acquired in vitro are unlikely to be the predominant mechanisms when resistance is acquired in vivo.Ongoing work focuses on characterizing unidentified mechanisms of gemR and on identifying agents with anti-tumor efficacy in these gemR models。 | Aubrey L.Miller Patrick L.Garcia Tracy L.Gamblin Rebecca B.Vance Karina J.Yoon | 2020 | Cancer Drug Resistance2020，3，3： | 1 |
| 4 | Empirical Evidence on Capital Investment,Growth Options,and Security Returns显示文摘 | Anderson C L.Garcia | | 0，，1： | 1 |
| 5 | Photosynthesis and conductance of spring‐wheat leaves: field response to continuous free‐air atmospheric CO2 enrichment显示文摘 | R. L.Garcia S. P.Long G. W.Wall C. P.Osborne B. A.Kimball G. Y.Nie P. J.Pinter R. L.Lamorte F.Wechsung | 2002 | Plant, Cell & Environment2002，，7： | 1 |
| 6 | Modelling extraordinary floods and sedimentological processes in a large channel-floodplain system of the Lower Paran River(Argentina)显示文摘A quasi-2D unsteady flow and sediment transport model suitable for the simulation of large lowland river systems,including their floodplains,is presented.The water flow and sediment equations are discretised using an interconnected irregular cells scheme,in which different simplifications of the 1D de Saint Venant equations are used to define the discharge laws between cells.Spatially-distributed transport and deposition of fine sediments throughout the river-floodplain system are simulated.The model is applied over a 208-km reach of the Parana River between the cities of Diamante and Ramallo(Argentina) comprising a river-floodplain area of 8100 km^2.After calibration and validation,the model is applied to predict water and sediment dynamics during synthetically generated extraordinary floods of100,1000,and 10,000 years return period.The potential impact of a 56-km long road embankment constructed across the entire floodplain is simulated and compared to model results without the embankment.The embankment results in increases in upstream water levels,inundation extent,flow duration,and sediment deposition. | Marina L.Garcia Pedro A.Basile Gerardo A.Riccardi José F.Rodriguez | 2015 | International Journal of Sediment Research2015，30，2： | 0 |
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