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| 1 | Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device显示文摘Convection-enhanced delivery(CED) is a promis ing technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6%(w/w) agarose tissue phantoms with isothermal conditions at 15 °C, 20 °C, 25 °C, and 30 °C. Infusion metrics were quantifled using a custom shadowgraphy setup and imageprocessing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 °C showing a 7-fold increase at 100 min over the 15 °C isothermal case. Infusions during photothermal heating(1064 nm at 500 mW) showed a similar eff ect with a 3.5-fold increase at 4 h over the control(0 mW). These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal. | R.Lyle Hood Rudy T.Andriani Tobias E.Ecker John L.Robertson Christopher G.Rylander | 2015 | Engineering2015，1，3： | 2 |
| 2 | Thrombophilia in pregnancy: a systematic review显示文摘 | L.Robertson O.Wu P.Langhorne S.Twaddle P.Clark G. D. O.Lowe I. D.Walker M.Greaves I.Brenkel L.Regan I. A.Greer | 2005 | British Journal of Haematology2005，，2： | 1 |
| 3 | Release of protein as well as activity of MMP‐9 from unstable atherosclerotic plaques during percutaneous coronary intervention显示文摘 | L.Robertson L.Grip L.Mattsson Hultén J.Hulthe O.Wiklund | 2007 | Journal of Internal Medicine2007，，6： | 1 |
| 4 | Thrombophilia in pregnancy: a systematic review显示文摘 | L.Robertson O.Wu P.Langhorne S.Twaddle P.Clark G. D. O.Lowe I. D.Walker M.Greaves I.Brenkel L.Regan I. A.Greer | 2005 | British Journal of Haematology2005，，2： | 1 |
| 5 | Thrombophilia in pregnancy: a systematic review显示文摘 | L.Robertson O.Wu P.Langhorne S.Twaddle P.Clark G. D. O.Lowe I. D.Walker M.Greaves I.Brenkel L.Regan I. A.Greer | 2005 | British Journal of Haematology2005，，2： | 1 |
| 6 | Thrombophilia in pregnancy: a systematic review显示文摘 | L.Robertson O.Wu P.Langhorne S.Twaddle P.Clark G. D. O.Lowe I. D.Walker M.Greaves I.Brenkel L.Regan I. A.Greer | 2005 | British Journal of Haematology2005，，2： | 1 |
| 7 | Thrombophilia in pregnancy: a systematic review显示文摘 | L.Robertson O.Wu P.Langhorne S.Twaddle P.Clark G. D. O.Lowe I. D.Walker M.Greaves I.Brenkel L.Regan I. A.Greer | 2005 | British Journal of Haematology2005，，2： | 1 |
| 8 | 美国总统的休闲生活显示文摘 1 With its long hours and psychological burden,the modern presidency is a stressful job.Consequently,rest and relaxation are important to the well-being of the president.…… | Daniel C.Diller Stephen L.Robertson 叶静 | 2008 | 海外英语2008，，12： | 0 |
| 9 | 切花的国际贸易显示文摘七十年代,切花和切枝、切叶的国际贸易额有了很大增长,这主要是由于在中南美洲(特别是哥伦比亚)、以色列、肯尼亚,以及近年又在墨西哥建成了一些新的生产基地;另一方面,发达的花卉生产中心如荷兰、意大利和加拿大也加强了他们的国际性花卉贸易活动。 | George L.Staby Jerry L.Robertson 邵健文 | 1984 | 世界农业1984，，12： | 0 |
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