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| 1 | Apoptotic cell death and its relationship to gastric carcinogenesis显示文摘AIM: To investigate the apoptotic process of cells with in the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. METHODS: Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. RESULTS: Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal metaplasia co-localized more with intestinal type carcinomas compared with diffuse type carcinomas [75% (21/28) vs 42% (6/14), respectively; P ≤0.05]. The mean apoptotic index in tumor cells was 0.70±0.08. The mean apoptotic index in intestinal metaplasias co-localizing to tumors was significantly higher than that of intestinal metaplasias co-localizing to chronic gastritis (0.70±0.03 vs 0.09±0.01, respectively; P≤0.05). p53 positivity was not observed in areas of intestinal metaplasia adjacent to tumors or chronic gastritis. Intestinal metaplasia areas adjacent to tumors showed lower cytoplasmic bcl-2 positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [55.5% (15/27) vs 70.5% (12/17), respectively]. On the other hand, intestinal metaplasia areas adjacent to tumors showed significantly higher cytoplasmic bax positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [44.4% (12/27) vs 11.7% (2/17), respectively; P ≤0.05]. CONCLUSION: Existence of apoptotic cells on the basis of TUNEL positivity is shown in intestinal metaplasias co-localizing to both diffuse and intestinal type gastric cancers in this study. Our results also suggested bax expression dependent induction of apoptosis especially in intestinal metaplasia areas adjacent to tumors. These findings strongly support the involvement of apoptotic mechanisms in the process of gastric carcinogenesis especially in the transition from intestinal metaplasia to gastric cancer. It may be suggested that induction of apoptosis in intestinal metaplasia areas adjacent to tumors may involve different mechanisms than induction by chronic inflammation. | Ferda Bir Nese Calli-Demirkan A Cevik Tufan Metin Akbulut N Lale Satiroglu-Tufan | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 2 | Mucociliary transport and its assessment:a review显示文摘 | LALE A M MASON J D JONES N S | 1998 | Clin Otolaryngol Allied Sci1998，23，： | 1 |
| 3 | Safety and efficacy of amphiphilic β-cyclodextrin nanoparticles for paclitaxel delivery显示文摘 | Erem Bilensoy Oya Gtirkaynak Dogan A Lale | 2008 | Int J Pharm2008，347，12： | 1 |
| 4 | The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity显示文摘 | Beck Stacy Wojdyla Daniel Say Lale Betran Ana Pilar Merialdi Mario Requejo Jennifer Harris Rubens Craig Menon Ramkumar Van Look Paul F A | 2010 | Bulletin of the World Health Organization2010，，1： | 1 |
| 5 | WHO analysis of causes of maternal death: a systematic review显示文摘 | Khalid S Khan Daniel Wojdyla Lale Say A Metin Gülmezoglu Paul FA Van Look | 2006 | 2006 (9516)2006，，9516： | 1 |
| 6 | Comparative evaluation of polymeric and amphiphilic cyclodextrin nanoparticles for effective camptothecin delivery 显示文摘 | Cirpanli Y Bilensoy E Lale Dogan A | 2009 | Eur J Pharm Biopharm2009，73，1： | 1 |
| 7 | Determination of Cu, Zn, Fe, Ni and Cd by flame atomic absorption spectrophotometry after preconcentration by Esche- richia coli immobilized on sepiolite显示文摘 | BAG H TURKER A R LALE M | 2000 | Talanta2000，51，： | 1 |
| 8 | WHO analysis of causes of maternal death: a systematic review显示文摘 | Khalid S Khan Daniel Wojdyla Lale Say A Metin Gülmezoglu Paul FA Van Look | 2006 | The Lancet2006，，9516： | 1 |
| 9 | Mucociliary transport and its assessment:a review 显示文摘 | LALE A M MASON J D T JONES N S | 1998 | Clinical Otolaryngollogy & Allied Sciences1998，23，5： | 1 |
| 10 | Maternal and umbilical cord blood lead levels: an Istanbul study显示文摘 | Furman A Laleli M | 2001 | Arch Environ Health2001，56，1： | 1 |
| 11 | WHO analysis of causes of maternal death: a systematic review显示文摘 | Khalid S Khan Daniel Wojdyla Lale Say A Metin Gülmezoglu Paul FA Van Look | 2006 | The Lancet2006，，9516： | 1 |
| 12 | Global causes of maternal death: a WHO systematic analysis显示文摘 | Lale Say Doris Chou Alison Gemmill ?zge Tun?alp Ann-Beth Moller Jane Daniels A Metin Gülmezoglu Marleen Temmerman Leontine Alkema | 2014 | The Lancet Global Health2014，，6： | 1 |
| 13 | WHO analysis of causes of maternal death: a systematic review显示文摘 | Khalid S Khan Daniel Wojdyla Lale Say A Metin Gülmezoglu Paul FA Van Look | 2006 | The Lancet . 2006 (9516)2006，，： | 1 |
| 14 | Determination of Cu, Zn, Fe, Ni and Cd by flame atomic absorption spectrophotometry after preconcentration by Escherichia coli immobilized on sepiolite 显示文摘 | HU SEYIN Bag A REHBER Turker MUSTAFA Lale | 2000 | Talanta2000，51，： | 1 |
| 15 | Adenocarcinoma of the ethmoid sinuses: A case of two primary tumours显示文摘 | MACE A D LALE A M CAPPER W R | 2002 | The Journal of Laryngology & Otology2002，116，9： | 1 |
| 16 | Separation and speciation of Cr( Ⅲ ) and Cr( Ⅵ ) with Saccharomyces cereisiae immobilized on sepiolite and determination of both species in water by FAAS 显示文摘 | Bag H Turker A R Lale M | 2000 | Talanta2000，51，5： | 1 |
| 17 | Determination of iron and nickel by flame atomic absorption spectrophotometry after preconcentration on saccharomyces cerevisiae immobilized sepiolite显示文摘 | Bag H Lale M Turker A R | 1998 | Talanta1998，47，3： | 1 |
| 18 | Determination of Cu, Zn, Fe, Ni and Cd by flame atomic absorption spectrophotometry after preconcentration by Escherichia coli immobilized on sepiolite显示文摘 | Bag H Turker A R Lale M | 2000 | Talanta2000，51，5： | 1 |
| 19 | Nitrogen utilization efficiency 显示文摘 | Samonte S O P B Wilson L T Medley J C Pinson S R M McClung A M Lales J S | 2006 | Agronomy Journal2006，98，1： | 1 |
| 20 | Stigma experienced by people using mental health services in San Diego County 显示文摘 | SARKIN A LALE R SKLAR M | 2015 | Soc Psychiatry Psychiatr Epidemiol2015，50，5： | 1 |
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