|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | Surgical management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the second most common cause of death from cancer worldwide. Standard potentially curative treatments are either resection or transplantation. The aim of this paper is to provide an overview of the surgical management of HCC, as well as highlight current issues in hepatic resection and transplantation. In summary, due to the relationship between HCC and chronic liver disease, the management of HCC depends both on tumourrelated and hepatic function-related considerations. As such, HCC is currently managed largely through nonsurgical means as the criteria, in relation to the above considerations, for surgical management is still largelyrestrictive. For early stage tumours, both resection and transplantation offer fairly good survival outcomes(5 years overall survival of around 50%). Selection therefore would depend on the level of hepatic function derangement, organ availability and local expertise. Patients with intermediate stage cancers have limited options, with resection being the only potential for cure. Otherwise, locoregional therapy with transarterial chemoembolization or radiofrequency ablation are viable options. Current issues in resection and transplantation are also briefly discussed such as laparoscopic resection, ablation vs resection, anatomical vs non-anatomical resection, transplantation vs resection, living donor liver transplantation and salvage liver transplantation. | Tony CY Pang Vincent WT Lam | 2015 | World Journal of Hepatology2015，7，2： | 10 |
| 3 | Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention显示文摘AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. | Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 4 | Cucurb-itacin B induces apoptosis and S phase cell cycle arrest in BEL-7402human hepatocellular carcinoma cells and is effective via oral admin-istration显示文摘 | Chan KT Meng FY Li Q Ho CY Lam TS To Y | 2010 | Cancer Lett2010，294，1： | 1 |
| 5 | Solid -cystic-papillarytumor: clin- icopathologic features in eight patients from hongkong and re- view of the literature 显示文摘 | Lam KY Lo CY Fan ST | 1999 | World J Surg1999，23，： | 1 |
| 6 | Routine parathyroid autotransplantation during thyroidectomy显示文摘 | Lo CY Lam KY | | 0，，03： | 1 |
| 7 | pancreatic solid-cystic-papllary tumor:clinicopathologic fe-Ture in eight patients from Hong Kong and review of the literature显示文摘 | Lam KY LO CY Fan ST | 1999 | WoldJ Surg1999，23，10： | 1 |
| 8 | Pancreatie solid -cystic papillary tumor: clinicopathologic features in eight patients from Hong Kong and review of the literature 显示文摘 | Lam KY Lo CY Fan ST | 1999 | World J Surg1999，23，10： | 1 |
| 9 | Telomerase activity in pancreatic endocrine tumours: a potential marker for malignancy显示文摘 | Lo CY Fan ST | 2000 | Mol Pathol2000，53，3： | 1 |
| 10 | Insular and anaplastic carcinoma of the thyroid: a 45-year comparative study at a single institution and a review of the sigificance of p53 and p21显示文摘 | Lam KY Lo CY Chan KW | 2000 | Am S urg2000，231，3： | 1 |
| 11 | Routine parathyroid autotansplanation during thyroidectomy显示文摘 | Lo CY Lam KY | 2001 | Surgery2001，129，3： | 1 |
| 12 | Postoperative hypocalcemia in patients who did or did not undergo parathyroid autotransplantation during thyroidecto- my: a comparative study显示文摘 | Lo CY Lam KY | 1998 | Surgery1998，124，6： | 1 |
| 13 | Primary 23-gauge transconjunctival sutureless vitrectomy for rhegmatogenous retinal detachment显示文摘 | Tsang CW Cheung BT Lam RF Lee GK Yuen CY Lai TY Lam DS | | 0，，08： | 1 |
| 14 | Pancreratic solid-cystic papillary tumor: clinicopathologic features in eight patients from hong kong and review of the literature 显示文摘 | Lam KY Lo CY Fan ST | 1999 | World J Surg1999，23，： | 1 |
| 15 | Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China, a randomized controlled trial显示文摘 | Wong CY Lam SK Wong WM | 2004 | JAMA2004，291，2： | 1 |
| 16 | Mercury-induced hepatotoxicity in zebrafish:in vivo mechanistic insights from transcriptome analysis,phenotype anchoring and targeted gene expression validation显示文摘 | Ung CY Lam SH Hlaing MM Winata CL Korzh S Mathavan S | 2010 | BMC Genomics2010，11，： | 1 |
| 17 | Pancreatic solid-cystic-papillary tumor: clinicopathologic features in eight patients from Hong Kong and review of the literature显示文摘 | Lam KY LO CY Fan ST | 1999 | World J Surg1999，23，10： | 1 |
| 18 | Opportunistic breast cancerscreening in Hong Kong: A revisit of the Kwong Wah Hospital expe-rience显示文摘 | Lui CY? Lam HS Chan LK | 2007 | Hong Kong Med2007，13，2： | 1 |
| 19 | Pharmacokinetics and pharmacodynamics of the taxanes显示文摘 | Francis YW Lam CY Chan J | 1997 | J Oncol Pharm Pract1997，3，2： | 1 |
| 20 | Malignancies after kidney transplantation : Hong Kong renal registry 显示文摘 | Cheung CY Lam MF Chu KH | 2012 | Am J Transplant2012，12，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员