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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 用带不同侧链的双取代聚乙炔衍生物增溶多壁碳纳米管显示文摘采用不同的双取代聚乙炔与多壁碳纳米管复合,通过π-π相互作用和聚合物链缠绕实现了对碳纳米管的增溶.这种方法对碳纳米管的结构没有损害,而且包覆到碳纳米管表面的双取代聚乙炔也显示了自身的荧光发射特性. | 袁望章 赵辉 徐海鹏 孙景志 LAM J W Y 毛宇 金佳科 张双 郑强 唐本忠 | 2007 | 高分子学报2007，17，10： | 5 |
| 3 | Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health显示文摘Gut microbes comprise a high density, biologically active community that lies at the interface of an animal with its nutritional environment. Consequently their activity profoundly influences many aspects of the physiology and metabolism of the host animal. A range of microbial structural components and metabolites directly interact with host intestinal cells and tissues to influence nutrient uptake and epithelial health. Endocrine, neuronal and lymphoid cells in the gut also integrate signals from these microbial factors to influence systemic responses. Dysregulation of these host-microbe interactions is now recognised as a major risk factor in the development of metabolic dysfunction. This is a two-way process and understanding the factors that tip host-microbiome homeostasis over to dysbiosis requires greater appreciation of the host feedbacks that contribute to regulation of microbial community composition. To date, numerous studies have employed taxonomic profiling approaches to explore the links between microbial composition and host outcomes(especially obesity and its comorbidities), but inconsistent host-microbe associations have been reported. Available data indicates multiple factors have contributed to discrepancies between studies. These include the high level of functional redundancy in host-microbiome interactions combined with individual variation in microbiome composition; differences in study design, diet composition and host system between studies; and inherent limitations to the resolution of r RNA-based community profiling. Accounting for these factors allows for recognition of the common microbial and host factors driving community composition and development of dysbiosis on high fat diets. New therapeutic intervention options are now emerging. | Connie WY Ha Yan Y Lam Andrew J Holmes | 2014 | World Journal of Gastroenterology2014，20，44： | 4 |
| 4 | Double-blind randomized sham controlled trial of intraperitoneal bupivacaine during emergency laparoscopic cholecystectomy显示文摘BACKGROUND: Intraperitoneal local anesthesia (IPLA) during elective laparoscopic cholecystectomy (el-LC) decreases post-operative pain. None of the studies have explored the efficacy of IPLA at emergency laparoscopic cholecystectomy (em-LC). A longer operative duration, the greater frequency of washing, and the inflammation associated with cholecystitis or pancreatitis are a few reasons why it cannot be assumed that a benefit in pain scores will be seen in em-LC with IPLA. This study was undertaken to assess the efficacy of IPLA in patients undergoing em-LC. METHODS: Double-blind randomized sham controlled trial was conducted of 41 consecutive subjects undergoing em-LC. IPLA was delivered by a combination of injection to the diaphragmatic and topical wash over the liver and gallbladder with bupivacaine or saline. The primary outcome was visual analogue scale pain scores until discharge. Secondary outcomes included pain scores in theatre recovery and analgesic consumption. RESULTS: One patient had a procedure converted to open and was excluded. There was no significant difference in pain scores in the ward or theatre recovery. Analgesic use, respiratory rate, oxygen saturation, duration to ambulation, eating, satisfaction scores, and time to discharge were comparable between the two groups. CONCLUSIONS: IPLA during em-LC does not influence postoperative pain. Other modalities of analgesia should be explored for decreasing the interval between diagnosis of acute admission and em-LC. | Keith J Roberts Jeff Gilmour Ruplay Pande James Hodson For Tai Lam Saboor Khan | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 3 |
| 5 | Battery performance enhancement with additions of bismuth显示文摘 | MANDERS J E LAM L T MARCO R D | 1994 | J Power Sources1994，48，： | 3 |
| 6 | Stability analysis and observer design for neutral delay systems 显示文摘 | Wang Z Lam J Burnham K J | 2001 | IEEE Trans on Automatic Control2001，47，8： | 2 |
| 7 | Anaerobic bacteria and intrahepatic stones: detections of Clostridium sp. and Bacteroides fragilis显示文摘To detect anaerobic bacteria Clostridium sp . and Bacteroides fragilis in intrahepatic stones by molecular genetic method Methods DNA was extracted from 59 stone samples and subjected to polymerase chain reaction (PCR) amplification targeting the 16S rRNA gene of Clostridium sp . and the glutamine synthetase gene of Bacteroides fragilis Single-strand conformational polymorphism (SSCP) analysis was performed to identify the Clostridium sp Results 16S rRNA gene sequences for Clostridium sp. were identified in 49 stones (83%, 49/59) The two most common groups were detected in 19 (41%) and 17 (37%) of the 46 samples using SSPC analysis, and 25/59 (42%) stones were tested positive for Bacteroides fragilis Conclusions Anaerobes such as Clostridium sp and Bacteroides fragilis present in intrahepatic stones and may play a role in stone formation PCR is a useful technique to detect fastidious pathogens, which are difficult to culture SSCP of PCR products is a rapid method in differentiating bacterial | LIU Yanlei Kan Lam Yajarayma J Tang Paul H Gumerlock Dong Ki Lee Myung Hwa Kim Sum P Lee Joseph SilvaJr Joseph W Leung | 2000 | Chinese Medical Journal2000，，9： | 2 |
| 8 | Stability analysis and observer design for neutral delay systems 显示文摘 | Wang Zidong Lam J Burnham K J | 2002 | IEEE Tran Automat Contr2002，47，3： | 2 |
| 9 | Current approaches to the management of acute primary angle-closure glaucoma显示文摘 | LAM D S THAM C C LAI J S | 2007 | Curr Opin Opthalmol2007，18，2： | 1 |
| 10 | A mathematical analysis of the DCT coefficient distributions for images显示文摘 | Lam E Y Goodman J W | 2000 | IEEE Transactions on Image Processing2000，9，10： | 1 |
| 11 | Network-based robust H∞ control of systems with uncertainty显示文摘 | YUE D HAN Q L LAM J | 2005 | Automatica2005，41，6： | 1 |
| 12 | The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population显示文摘 | Wang A H Lam W J Han D Y | 2011 | Human Immunology2011，72，： | 1 |
| 13 | Xylose fermentation by genetically modified Saccharomyces cerevisiae 259ST in spent sulrite liquor 显示文摘 | Helle S S Murray A Lam J | 2004 | Bioresource Technology2004，92，2： | 1 |
| 14 | Robust eigenstructure assignment under regional pole constaints显示文摘 | TAM H K LAM J | 1996 | IEEE1996，，12： | 1 |
| 15 | Robust D-stability analysis for uncertain discrete singular systems with state delay 显示文摘 | XU S Y LAM J ZHENG J | 2002 | IEEE Transactions on Circuits and Systems l2002，49，4： | 1 |
| 16 | Study on an ozone episode in hot season in Hong Kong and transboundary air pollution over Pearl River Delta region of China显示文摘 | Lam K S Wang T J Wu C L | 2005 | Atmospheric Environment2005，39，11： | 1 |
| 17 | Nueleolar pro- teome dynamics显示文摘 | Andersen J S Lam Y W Leung A K | 2005 | Nature2005，433，： | 1 |
| 18 | Electron microscopic observations of a marine fish iridovirus isolated from brown- spotted grouper, Epinephelus tauvina 显示文摘 | Qin Q w Lam T J Sin Y M | 2001 | J Virol Methods2001，98，： | 1 |
| 19 | Epidemiologieal features of supracondylar fractures of the humerus in Chinese children显示文摘 | Cheng J C Lam T P Maffulli N | 2001 | Pediatr Orthop B2001，10，： | 1 |
| 20 | Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole显示文摘 | Luo J D Xie Z L Lam J W Y | 2001 | Chem Commun2001，，： | 1 |
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