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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation显示文摘 | LAM C W JAMES JT Mc CLUSKEY R | 2004 | Toxicol Sci2004，77，1： | 1 |
| 4 | Recovery of lost or erroneously received motion vectors显示文摘 | Lam W M Reibman A R Liu B | 1993 | Minneapolis MN USA:Proceedings of ICASSP''93 Acoustics1993，5，4： | 1 |
| 5 | Pulmonary toxicity of single wall carbon nano-tubos in mice 7 and 90 days after intratracheal instillation显示文摘 | LAM C W JAMES J T MCCLUSKEY R | 2004 | Toxicological Sciences2004，77，1： | 1 |
| 6 | Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation显示文摘 | Lam C W James J T McCluskey R | 2004 | Toxicological Sciences2004，77，： | 1 |
| 7 | Culturing aerobic and anaerobic bacteria and mammalian cells with a microfluidic differential oxygenator 显示文摘 | LAM R H W KIM M C THORSEN T | 2009 | Anal Chem2009，81，14： | 1 |
| 8 | pulmonary toxicity of single-well carbon nanotubes in mice 7 and 90 days after intratracheal instillation显示文摘 | LAM C W JAMES J T MCCLUSKEY R | 2004 | Toxicological Sciences2004，77，1： | 1 |
| 9 | Numerical simulation of cross-flow around four cylinders in an in-line square configura- tion显示文摘 | Lam K Gong W Q So R M C | 2008 | Journal of Fluids and Structures2008，24，1： | 1 |
| 10 | Experimental Study on Embedded Steel Plate Composite Coupling Beams 显示文摘 | Lam W Y Su R K L Pam H J | 2005 | Journal of Structural Engineering2005，131，8： | 1 |
| 11 | In electrospray ionization source hydrogen/deuterium exchange LC-MS and LC-MS/MS for characterization of metabolites显示文摘 | Lam W Ramanathan R | 2002 | J Am Soc Mass Spectrom2002，13，： | 1 |
| 12 | Disconti- nuous innovation and supply relationships: Strategic dalliances显示文摘 | Phillips W Lamming R Bessant J | 2006 | R&D Management2006，36，4： | 1 |
| 13 | EDTA is a better anticoagulant than heparin or citrate for delayed blood processing for plasma DNA analysis显示文摘 | Lam N Y Rainer T H Chiu R W Lo Y M | 2004 | Clin Chem2004，50，： | 1 |
| 14 | X-Ray absorption spectroscopy of LiBF4 in propylene carbonate: A model lithium ion battery electrolyte 显示文摘 | SMITH J W LAM R K SHEARDY A T SHIH 0 RIZZUTO AM BORODIN 0 HARRIS S J PRENDERGAST D SAYKALLY R J | 2014 | Physical Chemistry Chemical Physic2014，16，23： | 1 |
| 15 | A Chinese family with familial paraganglioma syndrome due to succinate dehydrogenase deficiency 显示文摘 | Ma R C Lam C W Chan W B | 2007 | Hong Kong Med J2007，13，2： | 1 |
| 16 | Pulmonary toxicity of single Owall carbon nanotubes in mice 7 and 90 days after intratracheal instillation显示文摘 | Lam C W James J T McCluskey R | 2004 | Toxicol Sci2004，77，1： | 1 |
| 17 | Use of adenosine-5-triphosphate as an indicator of the microbial biomass in rumen contents显示文摘 | Forsberg C W Lam R | 1977 | Applied and Environmental Microbiology1977，33，： | 1 |
| 18 | Mesenchvreal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle显示文摘 | Ramaswamy R Fazekasoz H Lam E W | 2007 | Transplantation2007，83，1： | 1 |
| 19 | Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation显示文摘 | LAM C W JAMES J T McCLUSKEY R | 2004 | Toxicol Sci2004，77，1： | 1 |
| 20 | Capsaicin suppresses SP-induced joint inflammation in the rat 显示文摘 | Lam F Y Ferrell W R | 1989 | Neuro-Seienee Letter1989，105，1： | 1 |
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