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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | Culturing aerobic and anaerobic bacteria and mammalian cells with a microfluidic differential oxygenator 显示文摘 | LAM R H W KIM M C THORSEN T | 2009 | Anal Chem2009，81，14： | 1 |
| 4 | Experimental Study on Embedded Steel Plate Composite Coupling Beams 显示文摘 | Lam W Y Su R K L Pam H J | 2005 | Journal of Structural Engineering2005，131，8： | 1 |
| 5 | EDTA is a better anticoagulant than heparin or citrate for delayed blood processing for plasma DNA analysis显示文摘 | Lam N Y Rainer T H Chiu R W Lo Y M | 2004 | Clin Chem2004，50，： | 1 |
| 6 | Mesenchvreal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle显示文摘 | Ramaswamy R Fazekasoz H Lam E W | 2007 | Transplantation2007，83，1： | 1 |
| 7 | A novel introduction system for hydride generation- inductively coupled plasma mass spectrometry:determination of selenium in biological materials 显示文摘 | MOOR C LAM J W H STURGEON R E | 2000 | J Anal At Spectrom2000，15，2： | 1 |
| 8 | Genome sequence of the radioresistant bacteriumDeinococcus radiodurans R显示文摘 | White O Eisen J A Heidelberg J F Hickey E K Peterson J D Dodson R J Haft D H Gwinn M L Nelson W C Richardson D L Moffat K S Qin H Jiang L Pamphile W Crosby M Shen M Vamathevan J J Lam P McDonald L Utterback T Zalewski C Makarova K S Aravind L Daly M J Minton K W Fleischmann R D Ketchum K A Nelson K E Salzberg S Smith H O Venter J C Fraser C M | 1999 | Science1999，286，5444： | 1 |
| 9 | Thesequence and de novo assembly of the giant panda genome显示文摘 | LI R FAN W TIAN G ZHU H HE L CAI J HUANG Q CAIQ LI B BAI Y ZHANG Z ZHANG Y WANG W LI J WEI F LI H JIAN M LI J ZHANG Z NIELSEN R LI D GU W YANG Z XUAN Z RYDER OA LEUNG FC ZHOU Y CAO J SUN X FU Y FANG X GUO X WANG B HOU R SHEN F MU B NI P LIN R QIAN W WANG G YU C NIE W WANGJ WU Z LIANG H MIN J WU Q CHENG S RUAN J WANGM SHI Z WEN M LIU B REN X ZHENG H DONG D COOKK SHAN G ZHANG H KOSIOL C XIE X LU Z ZHENG H LI Y STEINER CC LAM TT LIN S ZHANG Q LI G TIAN J GONG T LIU H ZHANG D FANG L YE C ZHANG J HU W XU A REN Y ZHANG G BRUFORD MW LI Q MA L GUOY AN N HU Y ZHENG Y SHI Y LI Z LIU Q CHEN Y ZHAO J QU N ZHAO S TIAN F WANG X WANG H XU L LIU X VINAR T WANG Y LAM TW YIU SM LIU S ZHANGH LI D HUANG Y WANG X YANG G JIANG Z WANG J QIN N LI L LI J BOLUND L KRISTIANSEN K WONG GK OLSON M ZHANG X LI S YANG H WANG J WANG J | 2010 | Na-ture2010，463，： | 1 |
| 10 | Early diagnosis of intra-abdominal inflammation and sepsis by neutrophil CD64 expression in newborns显示文摘 | Lam H S Wong S P Cheung H M Chu W C Wong R P Chui K M | 2011 | Neonatology2011，99，： | 1 |
| 11 | Visible-light assisted photocatalytic degradation of gaseous formaldehyde by parallel-plate reactor coated with Cr ion-implanted Ti O2thin film显示文摘 | Lam R C W Leung M K H Leung D Y C | 2007 | Solar Energy Materials&Solar Cells2007，91，1： | 1 |
| 12 | Randomized controlled trial of transarterial lipiodol chemoembolization for unreseetable hepatocellular carcinoma显示文摘 | Lo C M Ngan H Tso W K Liu C L Lam C M Poon R T | 2002 | Hepatology2002，35，： | 1 |
| 13 | Strength and ductility of embedded steel composite coupling beams显示文摘 | LAM W Y SU R K L PAM H J | 2003 | International Journal of Advances in Structural Engineering2003，6，1： | 1 |
| 14 | Experimental study on embedded steel plate composite coupling beams显示文摘 | LAM W Y SU R K L PAM H J | 2005 | Journal of Structural Engineering ASCE2005，131，8： | 1 |
| 15 | Progression of middle cerebral artery occlusive disease and its relationship with further vascular events after stroke 显示文摘 | Wong K S Li H Lam W W Chan Y L Kay R | 2002 | Stroke2002，33，： | 1 |
| 16 | A gold(III)porphy?rin complex with antitumor properties targets the Wnt/-?catenin pathway 显示文摘 | Chow K H Sun R W Lam J B | 2010 | Cancer Res2010，70，1： | 1 |
| 17 | Effects of shear connectors on plate-reinforced composite coupling beams of short and medium-length spans显示文摘 | SU R K L PAM H J LAM W Y | 2006 | Journal of Constructional Steel Research2006，，62： | 1 |
| 18 | Citalo-pramandbupmpion- SR: conbining versus switching in patients with treatment resistant depression显示文摘 | Lam R W Hossie H Solomons K | 2004 | JClinPsychiatry2004，65，3： | 1 |
| 19 | Behavior of embedded steel plate in composite coupling beams显示文摘 | SU R K L LAM W Y PAM H J | 2008 | Journal of Constructional Steel Research2008，，64： | 1 |
| 20 | Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR : a meta-analysis 显示文摘 | KENNEDY S H ANDERSEN H F LAM R W | 2006 | J Psychiatry Neurosci2006，31，2： | 1 |
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