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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | 显示文摘 | Chen L C Hsu C Y Lan W H | 2003 | Solid-State Electronics2003，47，： | 1 |
| 3 | Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients显示文摘 | Dai Y Sui W Lan H | 2009 | Rheumatol Int2009，29，7： | 1 |
| 4 | Recovery of silicon powder from kerf loss slurry by centrifugation显示文摘 | Lin Y C Wang T Y Lan C W | 2010 | Powder Technology2010，200，03： | 1 |
| 5 | Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China 显示文摘 | Wang Y C Zhang H Y Xia N S Peng G Lan H Y Zhuang H Zhu Y H Li S W Tian K G Gu W J Lin W J Wu J X Li X Harrison T J | 2002 | Journal of Medical Virology2002，67，4： | 1 |
| 6 | Biosorption of Zn(Ⅱ) and Cu(Ⅱ) by the indigenous Thiobacillus thiooxidans显示文摘 | Liu H L Chen B Y Lan Y W | 2004 | Chem Eng J2004，97，： | 1 |
| 7 | Systemic and mucosal immu- nity in mice elicited by a single immunization with hu man adenovirus type 5 or 41 vector-based vaccines car- rying the spike protein of middle east respiratory syn drome coronavirus显示文摘 | Guo X Deng Y Chen H Lan J Wang W Zou X Hung T Lu Z Tan W | 2015 | Immunology2015，145，4： | 1 |
| 8 | Mouse embryonic head as a site for hematopoietic stem cell development 显示文摘 | Li Z Lan Y He W | 2012 | Cell Stem Cell2012，11，5： | 1 |
| 9 | Umbilical cord serum IgE concentration of Chinese babies in nong Kong 显示文摘 | Tseng R Y M Lan C W K Davies D P | 1987 | Acta Paediatr Scand1987，76，： | 1 |
| 10 | Studies on the synthe- sis and thermal properties of copoly(L-lactic acid/glycolic acid) by melt polycondesation显示文摘 | Lan P Zhang Y P Gao Q W | 2004 | Journal of Applied Pol- ymer Science2004，92，4： | 1 |
| 11 | Enhancing physical-layer secrecy in multiantenna wireless systems: an overview of signal processing approaches显示文摘 | Hong Y W P Lan Pang-chang and Kuo C C J | 2013 | IEEE Signal Processing Magazine2013，30，5： | 1 |
| 12 | Optimal dietary protein level and protein to energy ratio for growth of grouper(Epinephelus malabaricus)显示文摘 | Shiau S Y Lan C W | 1996 | Aquaculture1996，145，： | 1 |
| 13 | The role of the commensal gut microbial community in broiler chickens显示文摘 | Lan Y Verstegen M W A Tamminga S | 2005 | World''s Poultry Science Journal2005，61，1： | 1 |
| 14 | Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients显示文摘 | Dai Y Sui W Lan H | 2009 | Rheumatol Int2009，29，7： | 1 |
| 15 | The ash deposition mechanism in boilers burning Zhundong coal with high contents of sodium and calcium: A study from ash evaporating to condensing显示文摘 | XUEBIN W ZHAOXIA X BO W LAN Z HOUZHANG T TAO Y HRVOJE M NEVEN D | 2015 | Appl Therm Eng2015，80，： | 1 |
| 16 | Morphological instability due to dofJble diffusive convection in directional solidification: The pit formation显示文摘 | LAN C W TU C Y | 2000 | J Cryst Growth2000，220，： | 1 |
| 17 | Synthesis and luminescence properties of the red phosphor CaZrO3:Eu3+ for white lightemitting diode application 显示文摘 | HUANG J L ZHOU L Y LAN Y W | 2011 | Cent Eur J Phys2011，9，4： | 1 |
| 18 | De novo renal expression of macrophage migration inhibitory factor during the development of art crescentic glomerulonaphritis显示文摘 | Lan H Y Mu W Wang N | 1996 | Am J P Athol1996，149，： | 1 |
| 19 | A nationwide web-based automated system for outbreak early detection and rapid response in China 显示文摘 | Yang W Li Z Lan Y | 2011 | Western Pac Surveill Response J2011，2，1： | 1 |
| 20 | Evaluation of a proposed drift reduction technology high-speed wind tunnel testing protocol 显示文摘 | Hoffmann W C Fritz B K Lan Y | 2009 | Journal of ASTM International2009，6，4： | 1 |
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