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| 1 | High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease显示文摘AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [Crohn's disease(CD) and ulcerative colitis(UC)].METHODS:Thirty patients with CD(15 with at least one NOD2/CARD15 mutation),29 with UC,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood culture.RESULTS:MAP DNA was detected in all original blood samples and 8-wk blood cultures(CD,UC and non-IBD).Positive MAP DNA status was confirmed by dot blot assays.All 69 cultures were negative by acid-fast Ziehl-Neelsen staining.Viable MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 CD patients,one UC patient,and none of the non-IBD controls.No association was found between positive MAP cultures and use of immunosuppressive drugs or CDassociated single nucleotide polymorphisms.CONCLUSION:MAP is widely present in our area and MAP DNA can be recovered from the blood of CD,UC and non-IBD patients.However,MAP spheroplasts were only found in CD patients. | Juan L Mendoza Amparo San-Pedro Esther Culebras Raquel Cíes Carlos Taxonera Raquel Lana Elena Urcelay Fernando de la Torre Juan J Picazo Manuel Díaz-Rubio | 2010 | World Journal of Gastroenterology2010，16，36： | 5 |
| 2 | Mycobacterium avium subspecies paratuberculosis and its relationship with Crohn's disease显示文摘The hypothesis postulating that Mycobacterium avium paratuberculosis(MAP) is the cause of Crohn's disease(CD) has been circulating for many years.Advances in molecular techniques,such as polymerase chain reaction and culture methods,have enabled researchers to demonstrate that there is an association between MAP and CD.Recently,genome-wide association studies have identified novel susceptibility genes for CD,which are critical for generation of an adaptive immune response that is protective against intracellular pathogens,including M.tuberculosis infection.However,the role of MAP as a cause of CD suffered a setback with the report that administration of antimycobacterial therapy failed to lead to a sustained response in CD patients.Accordingly,this review sought neither to confirm nor refute this,but instead to survey recent literature on the role of MAP in CD. | Juan Luis Mendoza Raquel Lana Manuel Díaz-Rubio | 2009 | World Journal of Gastroenterology2009，15，4： | 4 |
| 3 | Inversion of Rayleigh wave phase and group velocities by simulated annealing显示文摘 | Martinez M D Lana X Olarte J | 2000 | Phys Earth Planet Inter2000，122，： | 1 |
| 4 | Characterization of abattery of monoclonal antibodies for differentiation of Newcastle-disease virus and pigeon paramyxovirus-1 strains显示文摘 | Lana D P Snyder D B King D J | 1988 | Avian Dis1988，32，2： | 1 |
| 5 | Executive functions and methylphenidate response in subtypes of attention-deficit/hyperactivity disorder显示文摘 | Gillian A O'Driscoll Lana Dépatie | 2005 | Biol Psychiatry2005，57，11： | 1 |
| 6 | Inhibition of non-enzy-matic glycation by silk extracts from a Mexican land race andmodern inbred lines of maize(Zea mays)显示文摘 | Farsi D A Harris C S Lana R | 2008 | Phytother Res2008，22，1： | 1 |
| 7 | Influence of catalyst properties and operating conditions on hydrodenitrogenation of quinoline显示文摘 | Rangwala H A Dalla Lana I G Otto F D | 1990 | Energy & Fuels1990，4，5： | 1 |
| 8 | Genetic mechanisms of antigenic variation in infectious bursal disease virus: analysis of a naturally occurring variant virus显示文摘 | LANA D P BEISEL C E SILVA R F | 1992 | Virus Genes1992，6，3： | 1 |
| 9 | Role of reduction sites in va- por-phase hydrolysis of carbonyl sulfide over alumina catalysts 显示文摘 | Akimoto M Lana I G D | 1980 | J Catal1980，62，1： | 1 |
| 10 | Hippocampal long term memory: effect of the cholinergic systemon local protein synthesis 显示文摘 | LANA D CERBAI F DIRUSS D J | 2013 | Neurobiol Learn Mere2013，106，3： | 1 |
| 11 | Cost-effectiveness analysis of trastuzumab in the adjuvant setting for treatment of HER2-positive breast cancer显示文摘 | Garrison LP Jr Lubeck D Lana D | 2007 | Cancer2007，110，3： | 1 |
| 12 | Nonsteroidal anti-inflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract:a trip from petic ulcer to colon cancer显示文摘 | Lanas Angel M D | 2009 | Am J Med Sci2009，338，2： | 1 |
| 13 | Ultrasound-assisted leaching-dispersive solid-phase extraction followed by liquid-liquid microextraction for the determination of polybrominated diphenyl ethers in sediment samples by gas chromatography-tandem mass spectrometry显示文摘 | FONTANA A R LANA N B MARTINEZ L D | 2010 | Talanta2010，82，1： | 1 |
| 14 | Nosocomial necrotizing enterocolitis outbreaks:epidemiology and control measures显示文摘 | Boccia D Stofli I Lana S | 2001 | Eur J Pediatr2001，160，6： | 1 |
| 15 | Short-term acetylsalicylic acid(aspirin) use for pain,fever,or colds-gastrointestinal adverse effects:a meta-analysis of randomized clinical trials显示文摘 | Lanas A McCarthy D Voelker M | | 0，，03： | 1 |
| 16 | Prevalence of mutations of the NOD2/CARD15 gene and relation to phenotype in Spanish patients with Crohn disease显示文摘 | J. L. Mendoza L. S. Murillo L. Ferná ndez A. S. Pe? a R. Lana E. Urcelay D. M. Cruz&hyphen Santamarí a E. G. de la Concha M. Dí az&hyphen Rubio J. Garcí a&hyphen Paredes | 2003 | Scandinavian Journal of Gastroenterology2003，，12： | 1 |
| 17 | Manifestaciones extraintestinales en la enfermedad inflamatoria intestinal: diferencias entre la enfermedad de Crohn y la colitis ulcerosa显示文摘 | Juan Luis Mendoza Raquel Lana Carlos Taxonera Cristina Alba Sonia Izquierdo Manuel Díaz-Rubio | 2005 | Medicina Clinica2005，，8： | 1 |
| 18 | Microbiology of wheat and flour milling in Australia 显示文摘 | Lana K B Ailsa D H Miskelly D | 2003 | International Journal Food Microbiology2003，85，： | 1 |
| 19 | Genetic mechanisms of antigenic variation in infectious bursa disease viruses:analysis of a naturally occurring variant virus显示文摘 | LANA D P BEISEL C E AND SILVA R F | 1992 | Virus Genes1992，6，： | 1 |
| 20 | Microbiology of wheat and flour milling in Australia显示文摘 | Lana K Berghofer Ailsa D Hocking Di Miskelly Edward Jansson | 2002 | International Journal of Food Microbiology2002，，1： | 1 |
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