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| 1 | ANTI-HYPOXIA AND ANTI-OXIDATION EFFECTS OF AMINOPHYLLINE ON HUMAN WITH ACUTE HIGH-ALTITUDE EXPOSURE显示文摘Objective To investigate the anti-hypoxia and anti-oxidation effects of aminophylline on human with acute high- altitude exposure. Methods Totally 100 young male army members newly recruited from Sichuan province (400 meters above sea level) were enrolled. They were randomly divided into two groups: 50 in aminophylline group (A group) and 50 in control group (C group). A group and C group orally took aminophylline and placebo respectively for 10 days, 7 days before entering Lhasa (3 658 meters above sea level) by air and 3 days after it. Several parameters were measured at three time points: before drug taken, 7 days after drug taken, and 3 days after ascending high altitude. These parameters included serum levels of nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT), hydrogen dioxide (H2O2), lactic acid (LA), as well as arterial oxygen saturation (SO2), arterial oxygen partial pressure (PaO2), and arterial carbon dioxide partial pressure (PaCO2). Statistical analysis was conducted to compare the difference between two groups with Stata 7.0 software system. Results There were no statistical differences between groups in hypoxia and oxidation indicators before and after drug taken in plain area. Three days after ascending high altitude, the serum levels of SOD, CAT, H2O2, LA, PaCO2 increased in both groups, yet to a much larger degree in C group than A group (P<0.01); and NO, SO2, PaO2 decreased more markedly in C group (P<0.05 for NO, P<0.0001 for SO2 and PaO2). Conclusion Aminophylline has significant anti-hypoxia and anti-oxidation effects at high altitude. | Bo Yang Guang-yi Wang Bin Chen Rong-bin Qin Si Lang Zha Xi Lian Chen | 2007 | Chinese Medical Sciences Journal2007，22，1： | 8 |
| 2 | ERK1/2-mediated Cytoplasmic Accumulation of hnRNPK Antagonizes TRAIL-induced Apoptosis through Upregulation of XIAP in H1299 Cells显示文摘Objective Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) resistance greatly limits the clinical therapeutic efficacy of TRAIL. Elucidating the molecular mechanism underlying TRAIL resistance will be fundamental to resolving this problem. Methods Nuclear and cytoplasmic protein extraction and immunofluorescence(IF) assay were used to detect changes in heterogeneous nuclear ribonucleoprotein K(hn RNPK) localization in H1299 cells. The evaluation of cell apoptosis in cells transfected with GFP-hn RNPK, GFP-hn RNPK S284/353 A, or GFP-hn RNPK S284/353 D mutant was performed using cleaved caspase-3 antibody. The gene expression of XIAP was tested by quantitative RT-PCR. Results Previously, we reported that hn RNPK antagonized TRAIL-induced apoptosis through inhibition of PKC-mediated GSK3β phosphorylation. In this study, we further demonstrate that TRAIL treatment induces cytoplasmic accumulation of hn RNPK in H1299 cells. The hn RNPK localized in the cytoplasm has a higher capacity to antagonize TRAIL-induced apoptosis. Both ERK1/2 signaling inhibitor U0126 and ERK-phosphoacceptor-site mutant(GFP-hn RNPK S284/353A) diminish cytoplasmic accumulation of hn RNPK induced by TRAIL. Moreover, we show that XIAP is involved in hn RNPK-mediated TRAIL resistance in H1299 cells. Conclusion Taken together, these results give new insights into the understanding of the molecular mechanism associated with TRAIL resistance in lung adenocarcinoma. | HUANG Wen Si XU Feng Mei ZENG Qing Zhong LIU Xiao Hui GAO Xue Juan LIU Lang Xia | 2017 | Biomedical and Environmental Sciences2017，30，7： | 5 |
| 3 | Evaluation of East Asian Summer Climate Prediction from the CESM Large-Ensemble Initialized Decadal Prediction Project显示文摘Based on surface air temperature and precipitation observation data and NCEP/NCAR atmospheric reanalysis data,this study evaluates the prediction of East Asian summer climate during 1959–2016 undertaken by the CESM(Community Earth System Model)large-ensemble initialized decadal prediction(CESM-DPLE)project.The results demonstrate that CESM-DPLE can reasonably capture the basic features of the East Asian summer climate and associated main atmospheric circulation patterns.In general,the prediction skill is quite high for surface air temperature,but less so for precipitation,on the interannual timescale.CESM-DPLE reproduces the anomalies of mid-and highlatitude atmospheric circulation and the East Asian monsoon and climate reasonably well,all of which are attributed to the teleconnection wave train driven by the Atlantic Multidecadal Oscillation(AMO).A transition into the warm phase of the AMO after the late 1990s decreased the geopotential height and enhanced the strength of the monsoon in East Asia via the teleconnection wave train during summer,leading to excessive precipitation and warming over East Asia.Altogether,CESM-DPLE is capable of predicting the summer temperature in East Asia on the interannual timescale,as well as the interdecadal variations of East Asian summer climate associated with the transition of AMO phases in the late 1990s,albeit with certain inadequacies remaining.The CESM-DPLE project provides an important resource for investigating and predicting the East Asian climate on the interannual and decadal timescales. | Dabang JIANG Dong SI Xianmei LANG | 2020 | Journal of Meteorological Research2020，34，2： | 2 |
| 4 | Ammonia in urban atmosphere can be substantially reduced by vehicle emission control:A case study in Shanghai, China显示文摘To investigate the impact of emission controls on ammonia(NH_(3)) pollution in urban atmosphere, observation on NH_(3)(1 hr interval) was performed in Shanghai before, during and after the 2019 China International Import Expo (CIIE) event, along with measurements on inorganic ions, organic tracers and stable nitrogen isotope compositions of ammonium in PM_(2.5). NH_(3)during the CIIE period was 6.5±1.0μg/m^(3), which is 41% and 32% lower than that before and after the event, respectively. Such a decrease was largely ascribed to the emission controls in nonagricultural sources, of which contribution for measured NH_(3)in control phase abated by ~20% compared to that during uncontrol period. Molecular compositions of PAHs and hopanes further suggested a dominant role of the reduced vehicle emissions in the urban NH_(3)abatement during the CIIE period. Our results revealed that vehicle exhaust emission control is an effective way to mitigate NH_(3)pollution and improve air quality in Chinese urban areas. | Can Wu Shaojun Lv Fanglin Wang Xiaodi Liu Jin Li Lang Liu Si Zhang Wei Du Shijie Liu Fan Zhang Jianjun Li Jingjing Meng Gehui Wang | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 5 | Shear en- hanced interfacial interaction between carbon nanotubes and polyethylene and formation of nanohybrid shish-kebabs 显示文摘 | LANG Si WANG Ke CHEN Daiqiang | 2008 | Polymer2008，49，23： | 1 |
| 6 | Vitamin C and quinapril abrogate LVH and endothelial dysfunction in aortic-banded guinea pigs显示文摘 | Bell JP Mosfer SI Lang D | 2001 | Am J Physiol Heart Circ Physiol2001，281，4： | 1 |
| 7 | Coronary microvascular endothelial cell redox state in left ventricular hypertrophy: the role of angiotensin Ⅱ 显示文摘 | Lang D Mosfer SI Shakesby A | 2000 | Cir Res2000，856，： | 1 |
| 8 | Significant coal combustion contribution to water-soluble brown carbon during winter in Xingtai, China: Optical properties and sources显示文摘To understand the characteristics of atmospheric brown carbon(BrC),daily PM2.5 samples in Xingtai,a small city in North China Plain(NCP),during the four seasons of 2018-2019,were collected and analyzed for optical properties and chemical compositions.The light absorption at 365 nm(abs λ=365 nm)displayed a strong seasonal variation with the highest value in winter(29.0±14.3 M/m),which was 3.2∼5.4-fold of that in other seasons.A strong correlation of abs λ=365 nm with benzo(b)fluoranthene(BbF)was only observed in winter,indicating that coal combustion was the major source for BrC in the season due to the enhanced domestic heating.The mass absorbing efficiency of BrC also exhibited a similar seasonal pattern,and was found to correlate linearly with the aerosol pH,suggesting a positive effect of aerosol acidity on the optical properties and formation of BrC in the city.Positive matrix factorization(PMF)analysis further showed that on a yearly basis the major source for BrC was biomass burning,which accounted for 34% of the total BrC,followed by secondary formation(26.7%),coal combustion(21.3%)and fugitive dust(18%).However,the contribution from coal combustionwas remarkably enhanced in winter,accounting for∼40%of the total.Our work revealed that more efforts of“shifting coal to clean energy”are necessary in rural areas and small cities in NCP in order to further mitigate PM2.5 pollution in China. | Dapeng Li Can Wu Si Zhang Yali Lei Shaojun Lv Wei Du Shijie Liu Fan Zhang Xiaodi Liu Lang Liu Jingjing Meng Yuesi Wang Jian Gao Gehui Wang | 2023 | Journal of Environmental Sciences2023，，2： | 1 |
| 9 | Planar peristrophic multiplexing metasurfaces显示文摘As a promising counterpart of two-dimensional metamaterials,metasurfaces enable to arbitrarily control the wavefront of light at subwavelength scale and hold promise for planar holography and applicable multiplexing devices.Nevertheless,the degrees of freedom(DoF)to orthogonally multiplex data have been almost exhausted.Compared with state-of-theart methods that extensively employ the orthogonal basis such as wavelength,polarization or orbital angular momentum,we propose an unprecedented method of peristrophic multiplexing by combining the spatial frequency orthogonality with the subwavelength detour phase principle.The orthogonal relationship between the spatial frequency of incident light and the locally shifted building blocks of metasurfaces can be regarded as an additional DoF.We experimentally demonstrate the viability of the multiplexed holograms.Moreover,this newly-explored orthogonality is compatible with conventional DoFs.Our findings will contribute to the development of multiplexing metasurfaces and provide a novel solution to nanophotonics,such as large-capacity chip-scale devices and highly integrated communication. | Jia Chen Dapeng Wang Guangyuan Si Siew Lang Teo Qian Wang Jiao Lin | 2023 | Opto-Electronic Advances2023，6，8： | 1 |
| 10 | Vitamin C and quinapril abrogate LVH and endothelial dysfunction in aortic-banded guinea pigs显示文摘 | Bell JP Mosfer SI Lang D | 2001 | Am J Physiol Heart Circ Physiol2001，281，4： | 1 |
| 11 | Combined delivery approach of bone marrow mononuclear stem cells early and late after myocardial infarction:the MYSTAR prospective,randomized study显示文摘 | Gy?ngy?si M Lang I Dettke M | | 0，，01： | 1 |
| 12 | Improvement of Pixel Electrode Circuit for Active-Matrix OLED by Application of Reversed-Biased Voltage 显示文摘 | Yujuan Si Liuqi Lang Yi Zhao | 2005 | IEEE Transactions on Circuits and Systems II: Express Briefs2005，52，12： | 1 |
| 13 | Coronary microvascular endothelial cell redox state in left ventricular hypertrophy:the role of angiotensin II显示文摘 | Lang D Mosfer SI Shakesby A | 2000 | Circ Res2000，86，4： | 1 |
| 14 | Role of adult bone marrow stem cells in the repair of ischemic myocardium:current state of the art显示文摘 | CHARWAT S GYNGYSI M LANG L | 2008 | Exp Hematol2008，36，6： | 1 |
| 15 | Sintering kinetics involving grain growth and densification of Mg-PSZ nanopowders显示文摘Sintering kinetics have been found to be effective in judging the evolution of ceramics.By using magnesium oxide-partially stabilized zirconia(Mg-PSZ)powder prepared by co-precipitation as raw materials,the evolution of densification and grain growth for Mg-PSZ ceramics were investigated.The results indicated that the densification of samples was mainly controlled by grain boundary diffusion in intermediate sintering stage.During the sintering process,the grain growth mechanisms included normal grain growth,abnormal grain growth and solid solution drag-controlled grain growth.Interestingly,the apparent activation energy for grain growth of Mg-PSZ ceramics is lower than that of ZrO_(2)–Y_(2)O_(3)ceramics in the solid solution drag-controlled grain grow process,which will cause grain to grow easily.The sintering kinetics and microstructure of Mg-PSZ ceramics were studied,and the kinetic equation of grain growth at different temperatures was established.The results show that the strength difference between Mg-PSZ and yttrium oxide-stabilized zirconia is closely related to the easy grain growth of Mg-PSZ ceramics. | Yi-ming She Jie-fu Lang Di An Chao-wei Si Xu-dong Luo Zhi-peng Xie Jie-gang You | 2022 | Journal of Iron and Steel Research(International)2022，29，7： | 0 |
| 16 | Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study显示文摘Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data. | Ren-Yi Su Sun-Bin Ling Qiao-Nan Shan Xu-Yong Wei Rui Wang Chang-Ku Jia Li Zhuang Tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-Bo Sun Guang-Ming Li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang Tao Jiang Qiang He Lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo Liu-Gen Lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo Wang Jiang Liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen Wang Lin Zhong Jing-Sheng Ma Qi-Gen Li Sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua Zhang Xuan Wang Zi-Qiang Li Mu-Jian Teng Jun-Jie Li Wen-Tao Jiang Jian-Hua Li Quan-Bao Zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang Xia Shao-Hua Song Zhi-Ren Fu Wei Qiu Guo-Yue Lv Rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou Gang Chen Ying-Peng Zhao Li Li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng Xiao Xu | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，2： | 0 |
| 17 | Autologous bone marrow infusion via portal vein combined with splenectomy for decompensated liver cirrhosis: A retrospective study显示文摘BACKGROUND In a previous study,autologous bone marrow infusion(ABMI)was performed in patients with decompensated liver cirrhosis(DLC)and acquired immunodefi-ciency syndrome and achieved good results,but whether splenectomy affected outcome was unclear.AIM To investigate the efficacy of ABMI combined with splenectomy for treatment of DLC.METHODS Eighty-three patients with DLC were divided into an intervention group(43 cases)and control group(40 cases)according to whether splenectomy was performed.The control group was treated with ABMI through the right omental RESULTS After ABMI,the prothrombin time,serum total bilirubin levels,ascites volume and model for end-stage liver disease score in both groups were significantly lower,while the albumin levels were significantly higher than before ABMI(P<0.01),but there were no significant differences between the groups(P>0.05).After ABMI,the white blood cell and platelets counts in both groups were significantly higher than before ABMI(P<0.01),and the counts in the intervention group were significantly higher than in the control group(P<0.01).After ABMI the CD4+and CD8+T cell counts in both groups were significantly higher than before ABMI(P<0.01).The CD8+T cell counts in the intervention group increased continuously and the increase had a shorter duration compared with control group.CONCLUSION ABMI through the portal vein in patients with DLC can significantly improve liver synthetic and secretory functions,and splenectomy promotes improvement of bone marrow hematopoietic and cellular immune functions. | Bao-Chi Liu Ming-Rong Cheng Lin Lang Lei Li Yan-Hui Si Ai-Jun Li Qing Xu Hui Zhang | 2023 | World Journal of Gastrointestinal Surgery2023，15，9： | 0 |
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