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| 1 | Surgery for Peyronie's disease显示文摘Peyronie 的疾病(PD ) 最简单地被叫作 fibrotic tunica albuginea 的愈合创伤的混乱。它两个都是引起阴茎畸形的身体上并且心理上地破坏的混乱,弯曲,依赖,变窄并且弄短,它可以妥协性功能。尽管许多非外科的处理被建议了,注明日期提议阴茎畸形的可靠、有效的修正的没有。作为结果,外科仍然是标准答案治疗选择,提供将是这篇文章的焦点的最快速、可靠的治疗。我们考察外科手术前的评估,外科的算法,接枝材料和 PD 的手术后的管理。为弄短的 tunical 的结果, tunical 为阴茎弄直变长和阴茎修复术放置被考察。Tunica albuginea 折襞是与足够的刚硬为人弄直的比较喜欢的方法,更少的严重疾病把不到 70 ° 定义为弯曲;没有缩小 / 依赖。有更多的严重、复杂畸形,但是维持强壮的外科手术前的可勃起的功能的人应该为与匾切口或部分切除和 grafting 弄直被认为候选人。最后为有不适当的刚硬和 PD 的那些人,有弄直的阴茎修复术放置两个都是地址的最好的途径问题。 | Laurence A Levine Stephen M Larsen | 2013 | Asian Journal of Andrology2013，15，1： | 9 |
| 2 | Pharmacological challenges in chronic pancreatitis显示文摘Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease.The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH,motility disorder,bacterial overgrowth and changed pancreatic gland secretion.Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention.The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal changes.Many patients limit their food intake because of the pain caused by eating and in some cases food intake is more or less substituted with alcohol,tobacco and coffee.Alcohol and drug interaction are known to influence the pharmacokinetics by altering either drug absorption or by affecting liver metabolism.Since patients suffering from chronic pancreatitis experience severe pain,opioids are often prescribed as pain treatment.Opioids have intrinsic effects on gastrointestinal motility and hence can modify the absorption of other drugs taken at the same time.Furthermore,the increased fluid absorption caused by opioids will decrease water available for drug dissolution and may hereby affect absorption of the drug.As stated above many factors can influence drug absorption and metabolism in patients with chronic pancreatitis.The factors may not have clinical relevance,but may explain inter-individual variations in responses to a given drug,in patients with chronic pancreatitis. | Anne Estrup Olesen Anne Brokjaer Iben WD Fisher Isabelle M Larsen | 2013 | World Journal of Gastroenterology2013，19，42： | 3 |
| 3 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 4 | How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility显示文摘Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is debated.The aim of this study was to compare successful resection rates(RR)with upfront ALPPS vs.PVE with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ALPPS.Methods:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day mortality.Results:A total of 189 patients were included.Successful RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on demand.The sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS. | Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok Peter Nørgaard Larsen Nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 2 |
| 5 | The role of nematophagous fungi in the biological control of nematode parasites of livestock显示文摘 | Waller P J Larsen M | 1993 | International Journal for Parasitology1993，23，4： | 2 |
| 6 | Isoprene and its degradation products as strong ozone precursors in Insubria, Northern Italy显示文摘 | M Duane B Poma D Rembges C Astorga B.R Larsen | 2002 | Atmospheric Environment2002，，24： | 2 |
| 7 | Tolyporphins J and K,two further porphinoid metabolites from the cyanobacterium tolypothrix nodosa 显示文摘 | Prinsep M R Patterson G M L Larsen L K | 1998 | J Nat Prod1998，61，： | 2 |
| 8 | Screening of selected pesticides for oestrogen rcceptor activation in vitro 显示文摘 | VINGGAARD A M BREINBOLT V LARSEN J C | 1999 | Food Addit Contam1999，16，12： | 1 |
| 9 | Nutrients in urine/ energetical aspects of removal and recovery 显示文摘 | Maurer M Schwegler P Larsen T A | 2003 | Water Sci Technol2003，48，1： | 1 |
| 10 | Interleukin- 1-receptor antagonist in type 2 diabetes mellitus 显示文摘 | Larsen C M Faulenbach M Vaag A | 2007 | N Engl J Med2007，356，： | 1 |
| 11 | CO methanation over supported bimetallic Ni-Fe catalysts: From computational studies towards catalyst optimization 显示文摘 | Kustov A L Frey A M Larsen K E | 2007 | Appl Catal A2007，320，： | 1 |
| 12 | Formaldehydeemission-Comparison of different standard methods显示文摘 | RISHOLM SUNDMAN M LARSEN A VESTIN E | 2007 | Atmospheric Enviroment2007，，41： | 1 |
| 13 | Acute interstitial pneumonia in mink kits inoculated with defined isolates of Aleutian mink disease parvovirus显示文摘 | Alexandersen S Larsen S Aasted B Uttenthal A Bloom M E Hansen M | 1994 | Vet Patho1994，31，2： | 1 |
| 14 | Production of volatile compounds by Rhizopus oligosporus during soybean and barley tempeh fermentation显示文摘 | FENG X M LARSEN T O SCHNORER J | 2007 | International Journal of Food Microbiology2007，113，2： | 1 |
| 15 | Distribution and petrogenetic behavior of trace elements in granitic pegmatite quartz from South Norway显示文摘 | Larsen R B Henderson I Ihlen P M | 2004 | Contributions to Mineralogy and Petrology2004，147，5： | 1 |
| 16 | Five-year outcome after mild head injury: A prospective controlled study显示文摘 | Jakola A S Mvller K Larsen M | 2007 | Acta Neurol Scand2007，115，39： | 1 |
| 17 | Monofocal outer retinitis associated with hand,foot,and mouth disease caused by coxsackievirus显示文摘 | Kessel L Larsen M | 2000 | Am J Ophthalmol2000，129，： | 1 |
| 18 | Ecoregions:an approach to surface water protection显示文摘 | Hughes R M Larsen D P | 1988 | Journal of the Water Pol- lution Control Federation1988，60，： | 1 |
| 19 | Estimating the precipitation potential in urine-collecting systems显示文摘 | Udert K M Larsen T A Gujer W | 2003 | Water Research2003，37，11： | 1 |
| 20 | 显示文摘 | Santora B P Larsen A O Gagne M R | 1998 | Organometallics1998，17，15： | 1 |
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