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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Responding to emergencies:lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 3 | Copper isotope ratios in magmatic and hydrothermal ore-forming environments显示文摘 | Peter B Larson Kierran Maher Frank C Ramos Zhaoshan Chang Miguel Gaspar Lawrence D Meinert | 2003 | Chemical Geology2003，，3： | 1 |
| 4 | Kinetics and heat transfer of CdZnTe Bridgman growth without wall contact 显示文摘 | ZHANG H LARSON JR D J WANG C L | 2003 | Journal of Crystal Growth2003，250，12： | 1 |
| 5 | A novel biomechanical model assessing continuous orthodontic archwire activation显示文摘 | Canales C Larson M Grauer D | 2013 | Am J Orthod Dentofacial Orthop2013，143，2： | 1 |
| 6 | The effect of setup uncertainties on the radiobiological advantage of fractionation in stereotaxic radiotherapy显示文摘 | Lo Y C Ling C C Larson D A | 1996 | In J Radiat Oncol Biol Plays1996，34，5： | 1 |
| 7 | Direct removal in the mouse of a floxed neo gene from a three-loxp conditional knockout allele by two novel approaches 显示文摘 | Li C Garrett-Beal L Larson D Wynshaw-Boris A Deng CX | 2001 | Genesis2001，30，1： | 1 |
| 8 | Elastic waves interacting with buried land mines: A study using the FDTD method显示文摘 | Scott W Jr Larson G D | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，： | 1 |
| 9 | Tungsten segregation in a2+Y titanium aluminides 显示文摘 | Larson D J Liu C T Miller M K | 1997 | Intermetallics1997，5，7： | 1 |
| 10 | Most apparent distortion:full-reference image quality assessment and therole of strategy显示文摘 | Larson E C Chandler D M | 2010 | Journal of Electronic Imaging2010，19，1： | 1 |
| 11 | Structural determinants of allosteric ligand activation in RXR heterodimers 显示文摘 | Shulman AI Larson C Mangelsdorf D J | 2004 | Cell2004，116，： | 1 |
| 12 | Responding to emergencies: Lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 13 | Electrical resistivity of thin epitaxially grown silver films 显示文摘 | LARSON D C BOIKO B T | 1964 | Applied Physics Letters1964，5，： | 1 |
| 14 | Infrared pupil- lometry to detect the light reflex during cardiopulmonary resuscitation: A case series 显示文摘 | Behrends M Niemann C U Larson M D | 2012 | Resuscitation2012，83，10： | 1 |
| 15 | Cross-classi-fication of JNC VI blood pressure stages and risk groups in the Framingham Heart study显示文摘 | Loyd-Jones D M Evans J C Larson M G | 1999 | Arch Intern Med1999，159，18： | 1 |
| 16 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 17 | 美国髋膝关节置换患者有多少?显示文摘越来越多的个人生活与髋膝关节置换密切相关。作者对美国的髋膝关节置换情况做了流行病学调查,从美国国家出院调查和医疗成本数据库中调取了1969-2010年的数据,并加以分析。结果发现,行髋、膝关节置换的患者分别占总人口的0.83%和1.52%,女性高于男性;80岁以上人群中,行髋、膝关节置换的患者分别占到10.38%和5.26%;且发病率趋向年轻化。 | Maradit Kremers H Larson D R Crowson C S 李军 | 2015 | 临床骨科杂志2015，18，6： | 1 |
| 18 | Economic scales for firslngener- ation biomass-gasifier/gas turbine combined cycles fueled from energy plantations显示文摘 | Larson E D Marrison C I | 1997 | Journal of Engineering for Gas Turbines and Power1997，119，2： | 1 |
| 19 | Benefits and risks of tight glucose control in critically ill adults:A meta-a- nalysis显示文摘 | Wiener R S Wiener D C Larson R J | 2008 | JAMA2008，300，8： | 1 |
| 20 | Crystal size distribution in continuous crystallizer when growth rate is size-dependent 显示文摘 | Abegg C F Stevens J D Larson M A | 1968 | AIChE J1968，14，： | 1 |
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