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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test显示文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. | Márcia Soares-Mota Tianny A Silva Luanda M Gomes Marco AS Pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 4 | A multisyringe flow injection method for the automated determination of sulfide in waters using a miniaturised optical fiber spectrophotometer 显示文摘 | Laura F Graciela A Manuel M | 2004 | Talanta2004，64，： | 1 |
| 5 | Processof Lemongrass Essential oil: Physicochemical Characteriza-tion and Assessment Quality of the Distillate and the ResidueProducts 显示文摘 | LAURA P T GLAUCIA M F P MARIA R W | 2011 | Industrial & Engineering Chemistry Research2011，50，13： | 1 |
| 6 | Thermogravimetric studies on the effect of support in sorbent-materials applied to flue gas desulfurization 显示文摘 | ROBERTO F ARTURO R CINTHYA P YULIANA M XOCHITL M LAURA G | 2008 | Fuel2008，87，： | 1 |
| 7 | Recombineering mycobacteria and their phages显示文摘 | Julia C V K Laura J M Graham F H | 2008 | Nat Rev Microbiol2008，6，11： | 1 |
| 8 | The potential impact of physical activity during pregnancy on maternal and neonatal outcomes显示文摘 | Zachary F M Laura G Kristi A B | 2012 | Obstet Gynecol Survey2012，67，2： | 1 |
| 9 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 10 | The dangers of immediate - release nifedipine for hypertensive cases显示文摘 | Aliya F M Laura A | 2002 | P&T Cme Credit2002，27，7： | 1 |
| 11 | Degradation of pharmaceuticals in non-Sterile urban wastewater by Trametes versicolor in a fluidized bed bioreactor显示文摘 | Caries C M Laura F C Sara R M | 2013 | Water Research2013，47，14： | 1 |
| 12 | Endoscopy for Anterior Pelvis Fixtion显示文摘 | Rubel F David S Laura M | 2002 | Orthop Traumar2002，16，： | 1 |
| 13 | Relative value of the lumbar spine and hip bone mineral density and bone turnover markers in men with ankylosing spondylitis显示文摘 | Laura M Marena RV Pilar F | 2011 | Clinical Rheumatology2011，30，5： | 1 |
| 14 | The influence of surface tension gradients on drop coalescence显示文摘 | BLANCHETTE F LAURA M JOHN W M B | 2009 | Physics of Fluids2009，21，07： | 1 |
| 15 | Model for the combined effects of temperature, initial pH,sodium chloride and sodium nitrite concentrations on anaerobic growth of Shigellaflexneri显示文摘 | LAURA L ROMBOUTS F M | 1994 | International Journal of Food Microbiology1994，23，： | 1 |
| 16 | Production of fermentation aroma compounds by Saccharomyces cerevisiae wine yeasts: effects of yeast assimilable nitrogen on two model strains显示文摘 | Carrau F M Karina M Laura F | 2008 | Fems Yeast Research2008，8，7： | 1 |
| 17 | Effect of reduced oocyte aging on the outcome of rescue intracytoplasmic sperm injection显示文摘 | Zsoh P Nagy Laura F Rienzi Filippo M Ubaldi | 2006 | Fertility and Sterility2006，85，4： | 1 |
| 18 | Growth of Shigella jlexneri in foods: comparison of observed and predicted growth kinetics parameters显示文摘 | LAURA ROMBOUTS F M | 1996 | International Journal of Food Microbiology1996，32，： | 1 |
| 19 | Journal o{ Inorganic Biochemistry 显示文摘 | Wolfhardt F Loria M Alessandra C Chiara B Keith F T Wolf gang L Laura El C | 2008 | 102 13292008，102，： | 1 |
| 20 | Determination of urinary ortho and meta-cresol in humans by headspace SPME gas chromatographymass spectrometry 显示文摘 | Silvia F Rosa M Laura C | 2005 | Chromatography2005，，2： | 1 |
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