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| 1 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 2 | Imaging resolution of biocatalytic activity using nanoscale scanning electrochemical microscopy显示文摘扫描电气化学的显微镜学代表一个强大的工具因为表面的电镀物品(化学药品) 描述,而是它的适用性在 microscale 在大多数情况中被限制了空间分辨率,和最大的挑战是为制造和纳米大小的尖端的使用按比例缩小到 nanoscale。这里,有纳米 electroactive 区域的磅 nanoelectrodes 为成像被制作并且采用金 nanoparticles (AuNPs ) 和在金表面上使不能调动的氧化还原作用活跃的酶的 bioelectrocatalytic 活动的分布。 | Jase M .Abad Alvaro Y. Tesio EmUiano Martinez-Perinan Felix Pariente Encamacion Lorenzo | 2018 | Nano Research2018，11，8： | 2 |
| 3 | Iron phthalocyanine supported on silica or encapsulated inside zeolite Y as solid photocatalysts for the degradation of phenols and sulfurheterocycles 显示文摘 | Alvaro M Carbonell E Espla M | 2005 | Appl Catal B: Env2005，57，： | 1 |
| 4 | Effect of Low-level Laser ( Ga-AlAs 655 nm) on Skeletal Muscle Fatigue Induced by Electrical Stimulation in Rats 显示文摘 | ALVARO R B LOPES-MARTINS RODRIGO L M | 2006 | J Appl Physiol2006，101，7： | 1 |
| 5 | Phenol biodegradation by Pseudomonas putida DSM 548 in a batch reactor显示文摘 | | 2000 | Biochemical Engineering Journal2000，6，1： | 1 |
| 6 | 显示文摘 | Sabater M J Garcia S Alvaro M | 1998 | J Am Chem Soc1998，120，33： | 1 |
| 7 | Outcome in Hodgkin's Lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells显示文摘 | Alvaro T Lejeune M Salvado MT | 2005 | Cli Cancer Res2005，11，4： | 1 |
| 8 | Dual role of interleukin 6 in regulating insulin sensitivity in mu rine skeletal muscle显示文摘 | Nieto Vazquez I Fernandez Veledo S de Alvaro C Lorenzo M | 2008 | Diabetes2008，57，： | 1 |
| 9 | Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NFkappaB through an AKT/P70S6K/p38-MAPK pathway 显示文摘 | Conejo R de Alvaro C Benito M | 2002 | Oncogene2002，21，23： | 1 |
| 10 | Ab- normal behavior detection using dominant sets 显示文摘 | MANUEL A AHDREA T ALVARO S M | 2014 | Machine Vision and Applications2014，25，5： | 1 |
| 11 | 显示文摘 | Baleizao C Das D | 2004 | J Catal2004，228，1： | 1 |
| 12 | Diagnosis of ventilator- associated pneumonia: a systematic review of the literature 显示文摘 | Alvaro Rea-Neto Nazah Cherif M Youssef | 2008 | Crit Care2008，12，2： | 1 |
| 13 | Giant versus small porphyry copper deposits of Cenozoic age in northern Chile: adakitic versus normal calc-alkaline magmatism显示文摘 | Roberto Oyarzun Alvaro Márquez Javier Lillo Ivan López Sergio Rivera | 2001 | Mineralium Deposita2001，，8： | 1 |
| 14 | Gold on diamond nanoparticles as a highly efficient fenton catalyst 显示文摘 | Navalon S Martin R Alvaro M | 2010 | Angewandte Chemie-International Edition2010，122，45： | 1 |
| 15 | Heterogeneous Fenton catalysts based on clays, silicas and zeolites显示文摘 | NAVALON S ALVARO M GARCIA H | 2010 | Applied Catalysis B:Environmental2010，99，12： | 1 |
| 16 | Functional molecules from single wall carbon nanotubes, photoinduced solubility of short single wall carbon nanotube residues by covalent anchoring of 2,4,6-triarylpyrylium units 显示文摘 | ALVARO M APRILE C FERRER B | 2007 | Journal of the American Chemical Society2007，129，17： | 1 |
| 17 | Cholangiocarcinoma:risk factors and clinical presentation 显示文摘 | Gatto M Alvaro D | 2010 | Eur Rev Med Pharmacol Sci2010，14，4： | 1 |
| 18 | Iron phthalocyanine supported on silica orencapsulated inside Zeolite Y as solid photocatalyst for the degradation of phenols andsulfur heterocycles显示文摘 | Alvaro M Carbonell E Espla M | 2005 | Appl Catalysis B:Environ2005，57，1： | 1 |
| 19 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 20 | Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes显示文摘 | Alvaro A Hagop K Taghi M | 2000 | Blood2000，1596，6： | 1 |
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