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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 3 | High-Resolution Surface-wave tomography from Ambient Seismic Noise显示文摘 | Nikolai M S Michel C Laurent S Michael H R | 2005 | Science2005，307，5715： | 1 |
| 4 | Benign and malignantvascular tumors of the liver in adults 显示文摘 | Bioulac-Sage P Laumonier H Laurent C | 2008 | Semin Liver Dis2008，28，3： | 1 |
| 5 | Effect of humic acid on toxicity of DDT and chlorpyrifos to freshwater and estuarine invertebrates显示文摘 | Laurent C M Robert C H | 2003 | Environmental Toxicology and Chemistry2003，23，3： | 1 |
| 6 | Association of adenoma and focal nodular hyperplasia:experience of a single French academic center显示文摘 | Laurent C Trillaud H Lepreux S | 2003 | Comp Hepatol2003，2，1： | 1 |
| 7 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 1 |
| 8 | NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism显示文摘 | Laurent M Martinerie C Thibout H | | 0，，： | 1 |
| 9 | Fruit quality and leaf photosynthesis in response to microenvironment modification around individual fruit by covering the fruit with plastic in nectarine and peach trees显示文摘 | LI S H GENARD M BUSSI C HUGUST J G HABIB R BESSET J LAURENT R | 2001 | Journal of Horticuhual Science &Biotechnology2001，76，1： | 1 |
| 10 | Prodrugs of gestodene for matrix-type transderrnal drug delivery systems显示文摘 | Lipp R Laurent H GOnther C | 1998 | Pharm Res1998，15，9： | 1 |
| 11 | Diagnostic value of inter- leukine-6,transforming growth factor-beta 1 and vascular endothelial growth factor in malignant pleural effusions 显示文摘 | Bernard C Jean-Louis C Laurent H | 2008 | Respiratory Medi- cine2008，102，： | 1 |
| 12 | Behaviour, capture and inertization of some trace elements during combustion of refuse-derived char from municipal solid waste显示文摘 | VASSILEV S V BRAEKMAN-DANHEUX C LAURENT P H THIEMANN T FONTAN A | 1999 | Fuel1999，78，26： | 1 |
| 13 | Benign and malignant vascular tumors of the liver in adults 显示文摘 | Bioulac-Sage P Laumonier H Laurent C | 2008 | Semin Liver Dis2008，28，3： | 1 |
| 14 | Meanvariance hedging and numeraire显示文摘 | GOURIEROUX C LAURENT J P PHAM H | 1998 | Mathematical Finance1998，8，3： | 1 |
| 15 | Carbon nanotubes in novel ceramic matrix nanocomposites 显示文摘 | Laurent C H Flahaut E | 2000 | Ceramics International2000，26，6： | 1 |
| 16 | Microwave Filters-Applications and Technology 显示文摘 | Ian C H Laurent B Bernard J | 2002 | Microwave Theory and Techniques IEEE Transactions on2002，50，3： | 1 |
| 17 | Flavonoid accumulation in Arabidopsis repressed in lignin synthesis affects auxin transport and plant growth显示文摘 | Besseau S Laurent H Pierrette G Lapierre C Pollet B | 2007 | The Plant Cell2007，19，： | 1 |
| 18 | 29Si MAS NMR study of dicalcium silicate: the structural influence of sulfate and alumina stabilizers显示文摘 | LAURENT B CATHERINE B DOMINIQUE M JEAN-PIERRE C BRUNO L H PIERRE C | 1995 | J Am Ceram Soc1995，78，10： | 1 |
| 19 | Influence of the gas density on the gas entrainment rate and gas holdup in loop- venturi reactors 显示文摘 | P H M R Cramers Laurent L Van Dierendinck A A C M Becnackers | 1992 | Chem Eng Sci1992，47，： | 1 |
| 20 | Prodrugs of gestodene for matrix-type transdermal drug delivery systems显示文摘 | Lipp R Laurent H Gunther C | 1998 | Pharm Res1998，15，9： | 1 |
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