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| 1 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 2 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 3 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 4 | Pentoxifylline treatment and penile calcifications in men Nith Peyronie's disease显示文摘 | James F Smith Alan W Shindel Yun-Ching Huang Raul I Clavijo Lawrence Flechner Benjamin N Breyer Michael L Eisenberg Tom F Lue | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
| 5 | Variability of environmental exposures to volatile organic compounds显示文摘 | STEPHEN M R LAWRENCE L K | 2004 | Journal of Exposure Science & Environmental Epidemiology2004，14，1： | 1 |
| 6 | The effect of salinity on growth and survival of Penaeus vannamei, with observations on the interaction of IHHN virus and salinity 显示文摘 | Bray W A Lawrence A L Leung-Trujillo J R | 1994 | Aquaculture1994，122，23： | 1 |
| 7 | Relationships between soil properties and vegetation at the Northern Experimental Forest, Howland, Maine显示文摘 | LEVINE L R KNOX R G AND LAWRENCE W T | 1994 | Remote Sensing of Environment1994，47，： | 1 |
| 8 | Attenuation,persistence,and vaccine potential of an Edwardsiella ictaluri purA mutant显示文摘 | Lawrence M L Cooper R K Thune R L | 1997 | Infection and Immunity1997，65，11： | 1 |
| 9 | Global elemental maps of the Moon: The lunar prospector gamma ray spectromet er显示文摘 | Lawrence D J Feldman W C Barraclough B L | 1998 | Science1998，281，： | 1 |
| 10 | Subaperture testing of aspheres with annular zones显示文摘 | Liu Y M Lawrence G N Koliopoulos C L | 1988 | Appl Opt1988，27，21： | 1 |
| 11 | The use of 3-Ddose volume analysis to predict radiation hepatitis显示文摘 | Lawrence T S Ten Haken R K Kessler M L | 1992 | Int J Radiat Oncol Biol Phys1992，23，9： | 1 |
| 12 | Pilot scale study of trace element vaporization and condensation during combustion of a pulverized subbituminous coal显示文摘 | Constance L Lawrence E | 2000 | Fuel Processing Technology2000，，63： | 1 |
| 13 | Context and Page Analysis for Improved Web Search显示文摘 | Lawrence S Giles C L | 1998 | IEEE Internet Computing1998，2，4： | 1 |
| 14 | The application of a piezoelectric bar gauge to shock tube studies显示文摘 | Edwards D H Davies L Lawrence T R | 1964 | J Sci Instrum1964，64，： | 1 |
| 15 | Observation on the decline in sperm quality of Penaeus serilferus under laboratory conditions 显示文摘 | Leung T J R Lawrence A L | 1987 | Aquaculture1987，65，： | 1 |
| 16 | Optimizing antibody panels for efficient and cost-effective flow cytometric diagnosis of acute leukemia显示文摘 | Haycocks NG Lawrence L Cain JW | 2011 | Cytometry B Clin Cytom2011，80，4： | 1 |
| 17 | Effects of dynamic exer- cise intensity on the activation of hormone-sensitive lipase in human skeletal muscle 显示文摘 | Watt M J George JF Lawrence L | 2003 | J Physiol2003，547，1： | 1 |
| 18 | Treatment of select open calcaneal fractures with reduction and inter-nal fixation:an intermediate term review 显示文摘 | l_outzenhiser L Lawrence S J Donegan RP | 2008 | Foot An-kle Int2008，29，8： | 1 |
| 19 | Measuring the efectiveness of cataract surgery:the reliability and validity of a visual function outcomes instrument显示文摘 | Lawrence D Brogan C Benjamin L | 1999 | Br J Ophthalmol1999，83，1： | 1 |
| 20 | Toxic moieties in ruminal and duodenal digesta and in milk, and hepatic integrity in cattle given diets based on rapeseed meals of different glucosinolate con tents either untreated or treated with heat or formaldehyde显示文摘 | Subuh A M H Rowa T G Lawrence T L J | 1995 | Animal Feed Science and Technology1995，52，： | 1 |
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