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| 1 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 2 | Palladium-Indium Catalyzed Reduction of N-Nitrosodimethylamine: Indium as a Promoter Metal显示文摘 | Matthew G Davie Kaimin Shih Federico A Pacheco | 2006 | Environmental Science &Technology2006，42，8： | 1 |
| 3 | Zea mays Annexins Modulate Cytosolic Free Ca^sup 2+^ and Generate a Ca^sup 2+^-Permeable Conductance(W)显示文摘 | Laohavisit Anuphon Mortimer Jennifer C Demidchik Vadim Coxon Katy M Stancombe Matthew A Macpherson Neil Brownlee Colin Hofmann Andreas Webb Alex A R Miedema Henk Battey Nicholas H Davies Julia M | 2009 | Plant Cell2009，，2： | 1 |
| 4 | Sterilization using high-pressure carbon dioxide 显示文摘 | Zhang J Davis T A Matthews M A | 2006 | The Journal of Supercritical Fluids2006，38，3： | 1 |
| 5 | Sterilization using high-pressure carbon dioxide显示文摘 | Zhang J Davis T A Matthews M A | 2006 | Journal of Supercritical Fluids2006，，38： | 1 |
| 6 | The relative role of peripheral blood and bone marrow for monitoring molecular evidence of disease in follicular lymphoma by quantitative real-time polymerase chain reaction显示文摘 | SUMMERS K E DAVIES A J MATTHEWS J | 2002 | Br J Haematol2002，118，： | 1 |
| 7 | Sterilization using high-pressure carbon dioxide显示文摘 | ZHANG J DAVIS T A MATTHEWS M A | 2006 | Supercrifical Fluids2006，38，： | 1 |
| 8 | Risk and clinical implications of Iransformation of follicular lymphoma to diffuse large B-cell lymphoma 显示文摘 | Montoto S Davies A J Matthews J | 2007 | J Clin Oncol2007，25，17： | 1 |
| 9 | The relative role of peripheral blood and bone marrow for monitoring molecular evidence of disease in follicular lymphoma by quantitative real-time polymerase chain reaction 显示文摘 | Summers KE Davies A J Matthews J | 2002 | Br J Haematol2002，118，2： | 1 |
| 10 | Sterilization using high-pressure carbon dioxide显示文摘 | ZHANG Jian DAVIS T A MATTHEWS M A | 2006 | The Journal of Supercritical Fluids2006，38，： | 1 |
| 11 | Sterilization using high- pressure carbon dioxide 显示文摘 | Zhang J Davis T A Matthews M A | 2006 | J of Supercritical Fluids2006，38，： | 1 |
| 12 | A comparison of modified Newton methods for unconstrained optimization显示文摘 | Matthews A Davies D | 1971 | Comput J1971，14，3： | 1 |
| 13 | Sterilization using high-pressure carbon dioxide显示文摘 | Zhang J Davis T A Matthews M A | 2006 | Journal of Supercritical Fluids2006，38，： | 1 |
| 14 | Future CO2 emissions and climate change from existing energy infrastructure 显示文摘 | Davis A J Caldeira K Matthews H D | 2010 | Science2010，329，5997： | 1 |
| 15 | Sterilization using high-pressure carbon dioxide显示文摘 | ZHANG Jian DAVIS T A MATTHEWS M A | 2006 | The Journal of Supereritical Fluids2006，38，： | 1 |
| 16 | Sterilization using high-pressure carbon dioxide显示文摘 | ZHANG J DAVIS T A MATTHEWS M A | 2006 | Journal of Supercritical Fluids2006，38，3： | 1 |
| 17 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020，，6： | 1 |
| 18 | Structures of isomeric substituted 14-crown-4 ethers and their LiSCN complexes显示文摘 | Burns John H Sachleben Richard A Davis Matthew C | | 0，，1： | 1 |
| 19 | Sterilizationusing high-pressure carbon dioxide显示文摘 | Zhang J Davis T A Matthews M A | 2006 | Journal ofSupercritical Fluids2006，38，3： | 1 |
| 20 | Sterilization using high-pressure carbon dioxide显示文摘 | ZHANG Jian DAVIS T A MATTHEWS M A | 2006 | Journal of Supercritical Fluids2006，38，5： | 1 |
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