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| 1 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 2 | Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study显示文摘 | Maarten J Titulaer Lindsey McCracken I?igo Gabilondo Thaís Armangué Carol Glaser Takahiro Iizuka Lawrence S Honig Susanne M Benseler Izumi Kawachi Eugenia Martinez-Hernandez Esther Aguilar Núria Gresa-Arribas Nicole Ryan-Florance Abiguei Torrents Albert S | 2013 | Lancet Neurology2013，，2： | 2 |
| 3 | The use of 3-Ddose volume analysis to predict radiation hepatitis显示文摘 | Lawrence T S Ten Haken R K Kessler M L | 1992 | Int J Radiat Oncol Biol Phys1992，23，9： | 1 |
| 4 | Allelie association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness 显示文摘 | Doull I J Lawrence S Watson M | 1996 | Am J Respir Grit Care Med1996，153，4： | 1 |
| 5 | A multicriteria approach to performance measurement in hospitals:A DEA approach显示文摘 | LAWRENCE K D LAWRENCE S M KLEINMAN G | 1999 | Advances in Mathematical Programming and Financial Planning1999，5，： | 1 |
| 6 | Allelic association of gene mairkers on chromosomes 5q and 11 q with atopy and bronchial hyperresponsiyeness 显示文摘 | DOULL J M LAWRENCE S WATON M | 1996 | AMJ Respir Critcare Med1996，153，： | 1 |
| 7 | Identification and molecular characterization of shrunken-2 cDNA clones of maize 显示文摘 | Bhave M R Lawrence S Barton C | 1990 | Plant Cell1990，2，： | 1 |
| 8 | Mixed-mode anion-cation exchange/hydrophilic interaction liquid chromatography-electrospray mass spectrometry as an alternative to reversed phase for small molecule drug discovery显示文摘 | STREGE M A STEVENSON S LAWRENCE S M | 2000 | Anal Chem2000，72，19： | 1 |
| 9 | A study of the Autographa californica multiple nucleopolyhedrovirus ODV envelope protein p74using a GFP tag显示文摘 | Slack J M Dougherty E M Lawrence S D | 2001 | J Gen Virol2001，82，9： | 1 |
| 10 | Tectonic evolution of the Cuvette Centrale, Congo显示文摘 | Daly M C Lawrence S R DiemuTshiband K | 1992 | Journal of the Geological Society1992，149，4： | 1 |
| 11 | The PsychologicalImpact Caused by Genital Warts:Has the Department ofHealth’s Choice of Vaccination Missed the Opportunity toPrevent Such Morbidity显示文摘 | Lawrence S Walzman M Sheppard S | 2009 | Int J STD AIDS2009，20，10： | 1 |
| 12 | Long-term results of hepatic artery fluorodeoxyuridine and conformal radiation therapy for primary hepatobiliary cancers显示文摘 | Robertson J M Lawrence T S Andrews J C | 1997 | Int J Radiat Oncol Biol Phys1997，37，4： | 1 |
| 13 | Hepatic toxicity resulting from cancer treatment显示文摘 | LAWRENCE T S ROBERTSON J M ANSCHER M S | 1995 | Int J Radiat Oncol Biol Phys1995，31，5： | 1 |
| 14 | Direct quantification of rare earth element concentrationsin natural waters by ICP-MS 显示文摘 | Lawrence M G Greig A Collerson K D Kamber B S | 2006 | Applied Geochemistry2006，21，： | 1 |
| 15 | The treatment of unstable thoracic spine fractures with transpedicular screw instrumentation: a 3- year consecutive series显示文摘 | Yue JJ Sossan A Selgrath C Deutsch Lawrence S Wilkens K Testaiuti M Gabriel JP | | 0，，： | 1 |
| 16 | A soluble form of P74can act as a per os infectivity factor to the Autographa californica multiple nucleopolyhedrovirus显示文摘 | Slack J M Lawrence S D Krell P J Arif1B M | 2010 | J Gen Virol2010，91，4： | 1 |
| 17 | Single clonal origin of a high proportion of Legionella pneumophila serogroup 1 isolates from patients and the environment in the area of Paris, France, over a 10-year period显示文摘 | LAWRENCE C REYROLLE M DUBROU S | 1999 | J Clin Microbiel1999，37，8： | 1 |
| 18 | Structural evolution and conductivity of PEO: LiBF4-MgO composite electrolytes 显示文摘 | BINOD K LAWRENCE S RICHARD M | 2001 | Electrochimica Acta2001，46，： | 1 |
| 19 | ShortRead: a bioconductor package for input, quality assessment and exploration of high-throughput se- quence data 显示文摘 | MORGAN M ANDERS S LAWRENCE M | 2009 | Bioinformatics2009，25，19： | 1 |
| 20 | Mutational heterogeneity in cancer and the search for new cancer-associated genes显示文摘 | LAWRENCE M S STOJANOV P POLAK P | 2013 | Nature2013，499，7457： | 1 |
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