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| 1 | 世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染显示文摘世界上有一半人口感染幽门螺杆菌(H.pylori),其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异.在发展中国家较高.发达国家较低。但总体而言,近年世界许多地区的H.pylori感染率均呈下降趋势。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖 戴宁 | 2011 | 胃肠病学2011，16，7： | 27 |
| 2 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 3 | Histone modifications:Targeting head and neck cancer stem cells显示文摘Head and neck squamous cell carcinoma(HNSCC) is the sixth most common cancer worldwide, and is responsible for a quarter of a million deaths annually. The survival rate for HNSCC patients is poor, showing only minor improvement in the last three decades. Despite new surgical techniques and chemotherapy protocols, tumor resistance to chemotherapy remains a significant challenge for HNSCC patients. Numerous mechanisms underlie chemoresistance, including genetic and epigenetic alterations in cancer cells that may be acquired during treatment and activation of mitogenic signaling pathways, such as nuclear factor kappa-light-chain-enhancer-of activated B cell, that cause reduced apoptosis. In addition to dysfunctional molecular signaling, emerging evidence reveals involvement of cancer stem cells(CSCs) in tumor development and in tumor resistance to chemotherapy and radiotherapy. These observations have sparked interest in understanding the mechanisms involved in the control of CSC function and fate. Post-translational modifications of histones dynamically influence gene expression independent of alterations to the DNA sequence. Recent findings from our group have shown that pharmacological induction of posttranslational modifications of tumor histones dynamically modulates CSC plasticity. These findings suggest that a better understanding of the biology of CSCs in response to epigenetic switches and pharmacological inhibitors of histone function may directly translate to the development of a mechanism-based strategy to disrupt CSCs. In this review, we present and discuss current knowledge on epigenetic modifications of HNSCC and CSC response to DNA methylation and histone modifications. In addition, we discuss chromatin modifications and their role in tumor resistance to therapy. | John M Le Cristiane H Squarize Rogerio M Castilho | 2014 | World Journal of Stem Cells2014，6，5： | 6 |
| 4 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 5 | 外耦合布拉格光栅 5μm量子级联激光器(英文)显示文摘窄带宽的 Al Ga As/ Ga As布拉格光栅耦合到 In P的半导体量子级联激光器从而产生稳定的激光频谱 ,其激光谱线宽度在 1纳米左右。如果不加光栅 ,非稳定的自由激射的激光器的谱线宽度有 3 0 nm左右。 | 彭川 LE H Q Sarangan A M Ishaug B Thompson L | 2003 | 重庆邮电学院学报(自然科学版)2003，15，3： | 4 |
| 6 | Generalization of the phase-screen approximation for the scattering of acoustic waves显示文摘 | DE HOOP M V LE ROUSSEAU J H WU R S | 2000 | Wave Motion2000，，31： | 1 |
| 7 | Cross sections calculations for electron oxygen scattering using the polarized orbital close coupling theory 显示文摘 | Vo Ky Lan Feautrier N Le Dourneuf M Regemorter H Van | 1972 | J Phys B1972，5，： | 1 |
| 8 | Measurements of surface roughness in cold metal rolling in the mixed lubrication regime 显示文摘 | SUTCLIFFE M P F LE H R | 2000 | Tribology Transaction2000，43，1： | 1 |
| 9 | A lower bound for S(2p(2p-1))显示文摘 | LE M H | 2001 | Smarandache Notions Journal2001，12，1： | 1 |
| 10 | Characterization of Ba- cillus pmbiotics available for human use显示文摘 | Due le H Hong H A Barbosa T M | 2004 | Appl Environ Micro- biol2004，70，4： | 1 |
| 11 | bryA:an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the masine bryozoan Bugula neritina显示文摘 | Hildebrand M Waggoner LE Liu H | 2004 | Chemistry & Biology2004，11，11： | 1 |
| 12 | The effect of surface deformation on lubrication and oxide-scale fracture in cold metal rolling显示文摘 | LE H R SUTCLIFFE M P F | 2004 | Metallurgical and Materials Transactions B2004，35，10： | 1 |
| 13 | The cytomegaloviral protein pUL138acts as potentiator of tumor necrosis factor(TNF)receptor 1surface density to enhance ULb'-encoded modulation of TNF-alpha signaling显示文摘 | Le VT Trilling M Hengel H | 2011 | J Virol2011，85，13： | 1 |
| 14 | A note on the diophantine equation 显示文摘 | Le M -H | 1989 | Proc Amer Math Soc1989，107，1： | 1 |
| 15 | Modeling the impact of summer temperatures on national electricity consumption显示文摘 | Le Comte D M Warren H E | 1981 | J Appl Meteor1981，20，12： | 1 |
| 16 | Modulation of liver injury by interleukin-10 显示文摘 | Louis H Le Moine O Goldman M | 2003 | Acta Gastroenterol Belg2003，66，1： | 1 |
| 17 | Relative influence of the topography and chemistry of TiAl6V4 surfaces on osteoblastic cell behaviour 显示文摘 | Anselme K Linez P Bigerelle M Le Maguer D Le Maguer A Hardouin P Hildebrand H F Iost A Leroy J M | 2000 | Biomaterials2000，21，： | 1 |
| 18 | Reaction of ozone and hydroxyl radicals with serine显示文摘 | Le Lacheur R M Glaze W H | 1996 | Environ Sci Technol1996，30，4： | 1 |
| 19 | Influence of host and non-host plant pollen on the calling and oviposition behaviour of the sunflower moth Homoeosoma nebulellure (Lepidoptera:Pyralidae)显示文摘 | Metayer M Le Pham-Delegue M H Thiery D | 1993 | Ecologica1993，14，5： | 1 |
| 20 | Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons 显示文摘 | Le H H Carlson E M Chua J P Belcher S M | 2008 | Toxicology Letters2008，176，2： | 1 |
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