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| 1 | 世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染显示文摘世界上有一半人口感染幽门螺杆菌(H.pylori),其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异.在发展中国家较高.发达国家较低。但总体而言,近年世界许多地区的H.pylori感染率均呈下降趋势。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖 戴宁 | 2011 | 胃肠病学2011，16，7： | 27 |
| 2 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 3 | Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma:A Pediatric Brain Tumor Consortium Study显示文摘PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received two doses of BVZ | Gururangan S Chi SN Young Poussaint T Onar-Thomas A Gilbertson RJ Vajapeyam S Friedman HS Packer RJ Rood BN Boyett JM Kun LE | 2010 | 中国神经肿瘤杂志2010，8，2： | 7 |
| 4 | Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. | H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani | 2007 | World Journal of Gastroenterology2007，13，17： | 6 |
| 5 | Donation after cardio-circulatory death liver transplantation显示文摘The renewed interest in donation after cardio-circulatory death (DCD) started in the 1990s following the limited success of the transplant community to expand the donation after brain-death (DBD) organ supply and following the request of potential DCD families. Since then, DCD organ procurement and transplantation activities have rapidly expanded, particularly for nonvital organs, like kidneys. In liver transplantation (LT), DCD donors are a valuable organ source that helps to decrease the mortality rate on the waiting lists and to increase the availability of organs for transplantation despite a higher risk of early graft dysfunction, more frequent vascular and ischemia-type biliary lesions, higher rates of re-listing and re-transplantation and lower graft survival, which are obviously due to theinevitable warm ischemia occurring during the declaration of death and organ retrieval process. Experimental strategies intervening in both donors and recipients at different phases of the transplantation process have focused on the attenuation of ischemia-reperfusion injury and already gained encouraging results, and some of them have found their way from pre-clinical success into clinical reality. The future of DCD-LT is promising. Concerted efforts should concentrate on the identification of suitable donors (probably Maastricht category Ⅲ DCD donors), better donor and recipient matching (high risk donors to low risk recipients), use of advanced organ preservation techniques (oxygenated hypothermic machine perfusion, normothermic machine perfusion, venous systemic oxygen persufflation), and pharmacological modulation (probably a multi-factorial biologic modulation strategy) so that DCD liver allografts could be safely utilized and attain equivalent results as DBD-LT. | Hieu Le Dinh Arnaud de Roover Abdour Kaba Séverine Lauwick Jean Joris Jean Delwaide Pierre Honoré Michel Meurisse Olivier Detry | 2012 | World Journal of Gastroenterology2012，18，33： | 6 |
| 6 | Intraocular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C显示文摘We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha (IFN-α) treatment in eight hepatitis C virus (HCV)-infected patients. These events include three cases of Vogt-Koyanagi-Harada like (VKH) disease (an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes), two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α treatment with ophthalmological monitoring if any ocular manifestation occurs. | Damien Sène Valérie Touitou Bahram Bodaghi David Saadoun Gabriel Perlemuter Nathalie Cassoux Jean-Charles Piette Phuc Le Hoang Patrice Cacoub | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 7 | Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples显示文摘瞄准:比较胰腺的腺癌织物标本的基因表示侧面,胰腺的人和腺癌和白血病房间线和正常的胰取样以便区分差别的冒号表示了基因并且在内视镜的指导超声的好针渴望( 指导EUS 的 FNA )由量的即时 RT-PCR ( RT-QPCR )验证基因的一个子集的微分表示标本。方法:包含 1176 基因的商业地奉献的癌症 cDNA 宏数组(地图集人癌症 1.2 ) 被使用。不同统计途径(层次聚类的、主要部件分析(PCA ) 和 SAM ) 被用来分析表示数据。RT-QPCR 和免疫组织化学的研究被用于结果的确认。结果:RT-QPCR 验证了 LCN2 的增加的表示(lipocalin 2 ) 并且第一次在恶意的胰的小块地(织物类型 plasminogen 使活跃之物或 tPA ) 同样与正常相比胰。Immunohistochemical 分析证实了在癌入侵的管的上皮细胞局部性的 LCN2 蛋白质的增加的表示。在与胰腺的腺癌从病人通过指导 EUS 的 FNA 获得的 12 件样品的小块地和 LCN2 抄本的分析与在正常纸巾发现的那些比较显示出显著地增加的表示层次,显示高质量的 RNA 的足够的数量能与这种技术被获得。结论:表示介绍是一个有用方法识别简历标记和潜在的目标基因。在胰腺的癌症的指导 EUS 的 FNA 样品的分子的分析为胰腺的腺癌的诊断作为珍贵策略出现。 | Henrik Laurell Michèle Bouisson Philippe Berthelémy Philippe Rochaix Sébastien Déjean Philippe Besse Christiana Susini Lucien Pradayrol Nicole Vaysse Louis Buscail | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 8 | Alternative splicing as a biomarker and potential target for drug discovery显示文摘其他的拼接在 pre-mRNA 成熟期间是 multi-exonic 基因表示的一个关键过程。在这个过程,基因的特别 exons 将被包括在以内或从最后的成熟 mRNA,和产生抄本排除了产生多样的蛋白质 isoforms。最近的证据证明有多重 exons 的约 95% 人的基因经历在 pre-mRNA 成熟期间的其他的拼接。因此,其他的拼接在生理的进程和房间开发程序起一个关键作用,其他的拼接的 and.dysregulation 高度与人的疾病被联系例如癌症,糖尿病和 neurodegenerative 疾病。在这评论,我们讨论其他的拼接的规定,检验在其他的拼接和人的疾病之间的关系,并且描述修改其他的拼接的几条途径,它能帮助人的疾病诊断和治疗。 | Kai-qin LE Bellur S PRABHAKAR Wan-jin HONG Liang-cheng LI | 2015 | Acta Pharmacologica Sinica2015，36，10： | 4 |
| 9 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 10 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 11 | Targeted prostate biopsy: value of multiparametric magnetic resonance imaging in detection of localized cancer显示文摘前列腺癌症是在人的第二很普通的癌症,与一最近的年里的世界健康组织全球报导的 110 万个新案例。指导活体检视被用于的 Transrectal 超声(TRUS ) 为超过 2 十年的前列腺癌症的诊断,而是这种技术对癌症通常盲目地点。而且, TRUS 活体检视的假否定的率被报导了象 47% 一样高。Multiparametric 磁性的回声成像(mp-MRI ) 包括 T1 加权、 T2 加权的成像象一样动态提高对比(数据通信设备) 并且散开加权的成像(DWI ) 。mp-MRI 是在前列腺癌症的成像的主要进展,启用可疑损害的指向的活体检视。演变指向的活体检视 techniques—包括的直接在里面厌烦活体检视,认知熔化和基于软件的 MRI 超声(MRI 美国) fusion—与更早的方法相比在癌症察觉导致了好几倍的改进。重要地,临床上重要的癌症的察觉被指向极大地便于,与系统的活体检视相比独自一个。经由 MRI 美国熔化的指向的活体检视可以戏剧性地改变前列腺癌症被诊断并且设法的方法。 | Jesse D Le Jiaoti Huang Leonard S Marks | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 12 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 13 | Spectral analysis and fingerprinting for biomedia characterisation显示文摘 | Marie-No?lle Pons Sébastien Le Bonté Olivier Potier | 2004 | Journal of Biotechnology2004，，1： | 2 |
| 14 | Internal nutrient efficiencies of irrigated lowland rice in tropical and subtropical Asia显示文摘 | C Witt A Dobermann S Abdulrachman H.C Gines Wang Guanghuo R Nagarajan S Satawatananont Tran Thuc Son Pham Sy Tan Le Van Tiem G.C Simbahan D.C Olk | 1999 | Field Crops Research1999，，2： | 2 |
| 15 | Bismuth-doped glass microsphere lasers显示文摘In this work, a hybrid structure consisting of a multicomponent germanate glass microsphere containing bismuth as a gain medium is proposed and presented. The bismuth-doped germanate glass microspheres were fabricated from a glass fiber tip with no precipitation of the bismuth metal. Coupling with a fiber taper, the bismuth-doped microsphere single-mode laser was observed to lase at around 1305.8 nm using 808 nm excitation. The low threshold of absorbed pump power at 215 μW makes this microlaser appealing for various applications, including tunable lasers for a range of purposes in telecommunication, biomedical, and optical information processing. | ZAIJIN FANG SíLE NIC CHORMAIC SHANYU WANG XIN WANG JIBO YU YUXUAN JIANG JIANRONG QIU PENGFEI WANG | 2017 | Photonics Research2017，5，6： | 2 |
| 16 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 17 | Involement of C - Abl tyrosine kinase in lipopolysaccharide- induced macrophage activation 显示文摘 | Le Quan Daniel R Chung S W | 1998 | J Immunnol1998，160，： | 2 |
| 18 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 19 | ZSM-5 zeolite with enhanced acidic properties显示文摘 | Le Van Mao R Le T S Fairbain M Muntasar A Xiao S Denes G | | 0，，： | 2 |
| 20 | A 2-Mb YAC,/BAC-based physical map of the ovum mutant(Om) locus region on mouse chromosome 11 显示文摘 | Cohen-Tannoudji M Vandormael-Poumin S Le Bras S | 2000 | Genomics2000，68，3： | 1 |
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