| 1 | Intramolecular aromatic-ring stacking interaction of ternary Zn(UTP)L^(2-) complexes显示文摘THE mechanism of the action of the classic platinum antitumor drugs can be interpreted accord-ing to their bidentate, bifunctional interaction with the DNA of the tumor cell, resulting in in-hibition of the DNA replication. Recently, it was found that a new class of compounds withthe general formula cis-[Pt(NH3)2(N-het)Cl]Cl(N-het is a heteroaromatic N-base like pyri-dine) show effective antitumor activities. However, two possible mechanisms of action | LE Xueyi, WU Fuhai, SONG Fenyun and Jl Liangnian1.Department of Chemistry, Zhongshan University, Guangzhou 510275, China State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2. Department of Hygienics, Guangdong Pharmaceutical School, Guangzhou 510224, China | 1997 | Chinese Science Bulletin1997，42，14： | 4 |
| 3 | Synthesis, Antibacterial Activities and Nuclease Properties of Ternary Copper(II) Complex Containing 2-(2'-Pyridyl)benzothiazole and Glycinate显示文摘新第三的建筑群[Cu (PBT )(Gly )(H2O )] ClO4 (PBT=2-(2-pyridyl ) benzothiazole,和 Gly=glycinate ) 被元素的分析,臼齿的传导性,和红外方法综合了并且描绘。建筑群,在结构上由单个水晶的 X 光检查晶体学描绘了,显示出在 PBT 和原子 O 和 Gly 的氨基的氮原子 N 在基础飞机绑的羧化物氧的二个氮原子的稍微弄歪的平方金字塔形的协作几何学,一个水分子在顶端的位置被协调。建筑群, Cu (ClO4 ) 2 并且免费 PBT 各为他们禁止二 Gram() 的生长的能力被测试(Escherichia 卷,沙门氏菌) 并且二克(+)( 杆菌 subtilis,葡萄球菌 aureus ) 微生物。建筑群与免费 PBT 和 Cu (ClO4 ) 相比对微生物显示出好抗菌剂活动 2。在在水的答案的建筑群和小牛胸腺 DNA 之间的相互作用用电子光谱学,荧光光谱学,圆形的二色性的光谱学,和粘性大小被调查。结果建议建筑群能由一个 intercalative 模式绑在 DNA。另外, agarose 胶化电气泳动的结果证明建筑群能由氢氧根激进分子和汗衫劈开 plasmid DNA 在生理的 pH 和房间温度的条件下面的像氧的种类。 | Lu,Yanmei Chen,Yongheng ou,Zhibin Chen,Shi Zhuang,Chuxiong Le,Xueyi | 2012 | Chinese Journal of Chemistry2012，30，2： | 0 |
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