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| 1 | Crohn’s and colitis in children and adolescents显示文摘Crohn's disease and ulcerative colitis can be grouped as the inflammatory bowel diseases(IBD).These conditions have become increasingly common in recent years,including in children and young people.Although much is known about aspects of the pathogenesis of these diseases,the precise aetiology is not yet understood,and there remains no cure.Recent data has illustrated the importance of a number of genes-several of these are important in the onset of IBD in early life,including in infancy.Pain,diarrhoea and weight loss are typical symptoms of paediatric Crohn's disease whereas bloody diarrhoea is more typical of colitis in children.However,atypical symptoms may occur in both conditions:these include isolated impairment of linear growth or presentation with extra-intestinal manifestations such as erythema nodosum.Growth and nutrition are commonly compromised at diagnosis in both Crohn's disease and colitis.Consideration of possible IBD and completion of appropriate investi-gations are essential to ensure prompt diagnosis,thereby avoiding the consequences of diagnostic delay.Patterns of disease including location and progression of IBD in childhood differ substantially from adultonset disease.Various treatment options are available for children and adolescents with IBD.Exclusive enteral nutrition plays a central role in the induction of remission of active Crohn's disease.Medical and surgical therapies need to considered within the context of a growing and developing child.The overall management of these chronic conditions in children should include multi-disciplinary expertise,with focus upon maintaining control of gut inflammation,optimising nutrition,growth and quality of life,whilst preventing disease or treatment-related complications. | Andrew S Day Oren Ledder Steven T Leach Daniel A Lemberg | 2012 | World Journal of Gastroenterology2012，18，41： | 4 |
| 2 | Synergistic effect of a recombinant N-terminal fragment of bactericidal/permeability-increasing protein and cefamandole in treatment of rabbit Gram-negative sepsis显示文摘 | Lin Y Leach WJ Ammons W S | 1996 | Antimicrob Agents Chemother1996，40，1： | 1 |
| 3 | Measuring the orbital angular momentum of a single photon显示文摘 | LEACH J PADGEFTT M J BARNETT S M | 2002 | Phys Rev Lett2002，88，25： | 1 |
| 4 | The relationship between chemiosmotic parameters and sensitivity to anions and organic acids in the acidophile Thiobacillus ferrooxidans显示文摘 | ALEXANDER B LEACH S 1NGLEDE W J | 1987 | Microbiology1987，133，5： | 1 |
| 5 | Group-level self-definition and self-investment:A hierarchical(multicomponent)model of in-group identification显示文摘 | Leach C Van Zomeren M Zebel S | 2008 | Journal of Personality and Social Psychology2008，95，1： | 1 |
| 6 | The growth performance,carcass characteristics,and meat quality of halothane carrier and negative pigs显示文摘 | Leach L M Ellis M Sutton D S | 1996 | Journal of Animal Science1996，74，： | 1 |
| 7 | Sulfur-containing compounds in the aroma volatiles of melons ( Cucumis mellon )显示文摘 | Wyllie S G Leach D H | 1992 | J Agric Food Chem1992，40，： | 1 |
| 8 | Transmission potential of smallpox in contemporary populations显示文摘 | Gani R Leach S | | 0，，： | 1 |
| 9 | A culture system to study oligodendrocyte myelination processes using engineered nanofibers显示文摘 | Lee S Leach MK Redmond SA | 2012 | Nat Methods2012，9，： | 1 |
| 10 | The increase in temperature of the anodic film formed on titanium during growth in acid media显示文摘 | Jouve G Leach J S L | 1983 | Thin Solid Films1983，110，： | 1 |
| 11 | The diagnosis and characteristics of moderate dry eye in non-contact lens wearers 显示文摘 | Narayanan S Miller WL Prager TC Jackson JA Leach NE McDermott AM | 2005 | Eye Contact Lens2005，31，3： | 1 |
| 12 | Respiratory detoxification of nitric oxide by the cytochrome c reductase of Escherichia coli 显示文摘 | Pook S Leach R Moir W | 2008 | Journal of Biological Chemistry2008，277，23： | 1 |
| 13 | Characteriza- tion of ubiquitin and uhiquitin-like-protein isopeptidase activi- ties显示文摘 | Nicholson B Leach C A Goldenberg S J | 2008 | Protein Sci2008，17，6： | 1 |
| 14 | leaching through undisturbed soil columns显示文摘 | PLEYSIER J L JUO A S R Leaching of fertilizer ions in a Ultisolfromthe high rainfall tropics | 1981 | Soil Science Society of America Journal1981，45，： | 1 |
| 15 | An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation显示文摘 | Mauze S Leach M W | 1999 | J Exp Med1999，190，7： | 1 |
| 16 | Radioprotective effects of flk2/flt3 ligand显示文摘 | Hudak S Leach MW Xu Y | 1998 | Exp Hematol1998，26，6： | 1 |
| 17 | Changes in the plasma membrane distribution of rice phospholipase D druing resistantions with Xanthomonas oryzae pvoryzae显示文摘 | Young S Wang X M Leach J E | 1996 | Plant Cell1996，8，： | 1 |
| 18 | Behaviour and control of influenza in institutions and small societies 显示文摘 | Finnie TJ Hall IM Leach S | 2012 | J R Soe Med2012，105，2： | 1 |
| 19 | Sulfur-containing compounds in the aroma volatiles of melons( Cucumis melo) 显示文摘 | Wyllie S G Leach D N | 1992 | J Ag- tic Food Chem1992，40，2： | 1 |
| 20 | The growth performance, carcass characteristics, and meat quality of halothane cartier and negative pigs显示文摘 | Leach M Ellis M Sutton D S | 1996 | J Anita Sci1996，74，： | 1 |
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