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| 1 | Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy显示文摘Real-time vibrational spectroscopic imaging is desired for monitoring cellular states and cellular processes in a label-free manner.Raman spectroscopic imaging of highly dynamic systems is inhibited by relatively slow spectral acquisition on millisecond to second scale.Here,we report microsecond scale vibrational spectroscopic imaging by lock-in free parallel detection of spectrally dispersed stimulated Raman scattering signal.Using a homebuilt tuned amplifier array,our method enables Raman spectral acquisition,within the window defined by the broadband pulse,at the speed of 32 μs and with close to shot-noise limited detection sensitivity.Incorporated with multivariate curve resolution analysis,our platform allows compositional mapping of lipid droplets in single live cells,observation of intracellular retinoid metabolism,discrimination of fat droplets from protein-rich organelles in Caenorhabditis elegans,spectral detection of fast flowing tumor cells and monitoring drug diffusion through skin tissue in vivo.The reported technique opens new opportunities for compositional analysis of cellular compartment in a microscope setting and high-throughput spectral profiling of single cells in a flow cytometer setting. | Chien-Sheng Liao Mikhail N Slipchenko Ping Wang Junjie Li Seung-Young Lee Robert A Oglesbee Ji-Xin Cheng | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 2 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 3 | The extent of algal and bacterial endosymbioses in protozoa显示文摘 | Lee J J Soldo A N Reisser W | 1985 | J Protozool1985，32，3： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | A major outbreak of severe acute respiratory syndrome in Hong Kong显示文摘 | LEE N HUI D WU A | 2003 | N Engl J Med2003，348，20： | 2 |
| 6 | Transcriptional repression of atherogenic inflammation:modulation by PPARδ显示文摘 | Lee CH Chawla A Urbiztondo N | 2003 | Science2003，302，5644： | 1 |
| 7 | A major outbreak of severe acute respiratory syndrome in Hong Kong显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，348，： | 1 |
| 8 | Recent developments in inductively coupled plasma magnetic sector multiple collector mass spectrometry 显示文摘 | Halliday A N Lee D C Christensen J N Walder A J Freedman P A Jones C E Hall C M Yi W Teagle D | 1995 | Int J Mass Spec Ion Proc1995，，： | 1 |
| 9 | Thrombospondin modules and angiogenesis显示文摘 | Iruela-Arispe ML Luque A Lee N | 2004 | Int J Biochem Cell Biol2004，36，6： | 1 |
| 10 | Label free bioelectronic detection of aptamer-protein interaction 显示文摘 | Kawde A N Rodriguez M C Lee T M H | 2005 | Electrochem Commun2005，，7： | 1 |
| 11 | microRNA directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems 显示文摘 | Kim J Jung J H Reyes J L kim Y S Kim S Y Chung K S Kiln J A Lee M Lee Y Kim V N | 2005 | The Plant Journal2005，42，： | 1 |
| 12 | Core formation on Mars and differentiated asteroids 显示文摘 | Lee D C Halliday A N | 1997 | Nature1997，388，： | 1 |
| 13 | Nonlinear dynamic of the 3D pendulum显示文摘 | Chaturvedi N A Lee T Leok M | 2011 | J of Nonlinear Science2011，21，1： | 1 |
| 14 | Prognostic implication of ST-segment resolution following primary percutaneous transluminal coronary angioplasty for ST-elevation acute myocardial infarction显示文摘 | Lee AK Sadick N Ng A | 2004 | Intern Med J2004，34，910： | 1 |
| 15 | An FPGA-based novel digital PWM control scheme for BLDC motor drives 显示文摘 | Sathyan A Milivojevic N Young-Joo Lee | 2009 | In- dustrial Electronics2009，56，8： | 1 |
| 16 | Olfactomedin 1 interacts with the nogo a receptor complex to regulate axon growth显示文摘 | Nakaya N Sultana A Lee H-S | 2012 | Journal of Biological Chemistry2012，287，37： | 1 |
| 17 | Hyaluronidases, a group of glycosidases: Current and future perspectives显示文摘 | EI-Safory N S Fazary A E Lee C K | 2010 | Carbohydr Polym2010，81，11： | 1 |
| 18 | A major outbreak of severe acute respiratory syndrome in Hong Kong 显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，7，： | 1 |
| 19 | Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，14，： | 1 |
| 20 | A major outbreak of severe acute respiratory syndrome in Hong Kong显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，348，20： | 1 |
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