|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 急性下呼吸道感染儿童的维生素D摄入显示文摘目的明确维生素D(Vit D)摄入是否与儿童急性下呼吸道感染(ALRI)相关。方法比较因毛细支气管炎或肺炎入院的5岁以下儿童和非配对、无呼吸道感染的同龄对照组儿童之间Vit D摄入的差别。197例儿童的看护人完成了问卷调查,内容包括人口统计变量、ALRI危险因素和饮食。评估ALRI与Vit D摄入及其他危险因素的相关性。结果 ALRI组儿童的平均Vit D摄入为每日48 IU/kg,对照组为每日60 IU/kg。当控制年龄、民族、社会经济地位、北部地区居住、母乳喂养、免疫接种和接触吸烟等因素时,Vit D每日摄入<80 IU/kg的儿童患ALRI的可能性比每日摄入≥80 IU/kg的儿童高4倍(OR=4.9;95%CI:1.5~16.4)。结论为了避免罹患ALRI等疾病,5岁以下儿童可能需要摄入比现在推荐量更高的Vit D剂量。因毛细支气管炎和肺炎是年幼儿童住院的最常见原因,增加Vit D的补充可能有重要的公共卫生保健意义。 | Karen S Leis J Dayre McNally Matthew R Montgomery Koravangattu Sankaran Chandima Karunanayake Alan M Rosenberg 马丽亚(译) | 2012 | 中国当代儿科杂志2012，14，1： | 25 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 4 | A model for predicting aeolian sand drift entrainment on scales from paddock to region 显示文摘 | Shao Y Raupach M R Leys J F | 1996 | Soil Research1996，34，2： | 1 |
| 5 | Bradycardia induces angiogenesis, increases coronary reserve, and preserves function in postinfarcted heart显示文摘 | LEI L ZHENG W TOMANEK R J | 2004 | Circulation2004，110，7： | 1 |
| 6 | Rate control in DCT video coding for low-delay communications 显示文摘 | Corbera J R Lei S | 1999 | IEEE Trans on CSVT1999，9，1： | 1 |
| 7 | Ordered crystslline TiO2 nanotube arrays on transparent FTO Glass for efficient dye-sensitized solar cells 显示文摘 | Lei B X Liao J Y Zhang R | 2010 | J Plays Chem C2010，114，15： | 1 |
| 8 | 查看详情显示文摘 | Xu X R Lei G Shen M Y Zhao G Z J | | 0，，： | 1 |
| 9 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 10 | Study of a proposed tunnel evacuation passageway formed by opposite-double air cur- tain ventilation 显示文摘 | GAO R LI A LEI W J | 2012 | Safety Science2012，50，7： | 1 |
| 11 | A model for predicting Aeolian sand drift and dust entrainment on scales from paddock to region 显示文摘 | Shao Yaping Raupach M R Leys J F | 1996 | Aust J Soil Res1996，34，： | 1 |
| 12 | A model for predictingAeolian sand drift entrainment on scales from paddock toregion 显示文摘 | Shao Y Raupach M R Leys J F | 1996 | Australian Journal of Soil Research1996，34，3： | 1 |
| 13 | Diffraction-pattern calculation and phase identification of hypothetical crystalline C3N4 显示文摘 | Wang J Lei J Wang R | 1998 | Phys Rev B1998，，： | 1 |
| 14 | Thermolumine- scence and temperature-dependent afterglow properties in BaSi202N2 : Eu2+ 显示文摘 | Qin J L Zhang H R Lei B F | 2013 | Journal of the American Ceramic Society2013，96，10： | 1 |
| 15 | Honeys from Different Floral Sources as lnhibitors of Enzymatic Browning in Fruit and Vegetable Homogcnates 显示文摘 | LEI CHEN AMAR MEHTA MAY BERENBAUM ARTHUR R ZANGERL and NICKI J ENGESETH | 2000 | J Agric Food Chem2000，，48： | 1 |
| 16 | 显示文摘 | Ying J R Lei M Jiang C Y | 2006 | J Power Sources2006，158，1： | 1 |
| 17 | Preparation of SrSi2 02 N+ : Eu2+ phosphor by SrSi alloy precursor and its long-lasting phosphorescence properties 显示文摘 | Zhang H R Lei B F Qin J L | 2013 | Jour- nal of the American Ceramic Society2013，96，6： | 1 |
| 18 | A novel structural design of CNx-Fe3 O4 as support to immobilize Pd for catalytic oxidation of formic acid显示文摘 | JIA J WANG R WANG H JI S KEY J LINKOV V SHI K LEI Z | 2011 | Catal Commun2011，16，1： | 1 |
| 19 | Dielectric Properties of Azo-Poly(Methyl Methacrylate) Mixtures显示文摘 | Runt J Du Lei Safari A Newnham R E | 1987 | Macromolecules1987，20，1987： | 1 |
| 20 | The effect of roughness elements on wind erosion threshold 显示文摘 | Raupach M R Gilleuc A D Leys J F | 1993 | J Geophys Res1993，98，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员