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| 1 | Cyclin A2:At the crossroads of cell cycle and cell invasion显示文摘Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However,whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed,recent observations show that a small fraction of cyclin A2 persists beyond metaphase and is degraded by autophagy. Its implication in the control of cytoskeletal dynamics and cell movement has unveiled its role in the modulation of Rho A activity. Since this GTPase is involved in both cell rounding early in mitosis and later,in the formation of the cleavage furrow,this suggests that cyclin A2 is a novel actor in cytokinesis. Taken together,these data point to this cyclin as a potential mediator of cell-niche interactions whose dysregulation could be taken as a hallmark of metastasis. | Abdelhalim Loukil Caroline T Cheung Nawal Bendris Bénédicte Lemmers Marion Peter Jean Marie Blanchard | 2015 | World Journal of Biological Chemistry2015，6，4： | 6 |
| 2 | 昼夜周期节律与给药显示文摘人体功能如心血管(血压、心率和血流量等)、肺、肝和肾等的功能均存在昼夜周期节律。症状和疾病的发生,例如冠状动脉梗塞、心绞痛及哮喘发作等,在昼夜24小时中也非均等分布。因此,药物疗效和/或药物动力学表现明显的日周期变化也就不足为奇。新近有关H_2-阻滞剂、平喘药(茶碱、叔丁喘宁)、心血管活性药物(心得安、硝酸酯、心痛定)的药物动力学和药效学资料即为其典型实例。这些资料阐明了药物治疗的基础,在评价给药系统、药剂配制和药物动力学时应当考虑生物周期节律。 | Lemmer B 吕建强 | 1993 | 国外医学(内科学分册)1993，20，3： | 6 |
| 3 | Role of Pirh2 in mediating the regulation of p53 and c-Myc显示文摘 | Hakem A Bohgaki M Lemmers B | 2011 | PLo S Genet2011，7，10： | 1 |
| 4 | Chronopharmacology--importance of the biological clock in drug treatment显示文摘 | Lemmer B | 2009 | Med Monatsschr Pharm2009，32，11： | 1 |
| 5 | Cell cycle, cytoskeleton dynamics and beyond: the many functions of Cyclins and CDK inhibitor显示文摘 | Bendris N Lemmers B Blanchard JM | 2015 | Cell Cycle2015，14，17： | 1 |
| 6 | LNG receiving and regasifica- tion terminal operations 显示文摘 | LEMMERS S p B Fluor Haarlem B V | 2005 | Hydrocarbon Processing2005，，7： | 1 |
| 7 | Effects of music composed by Mozart and Ligeti on blood pressure and heart rate circadian rhythms in normotensive and hypertensive rats 显示文摘 | Lemmer B | 2008 | Chronobiol Int2008，25，6： | 1 |
| 8 | Circadian rhythms and drug delivery 显示文摘 | LEMMER B | 1991 | J Controlled Release1991，16，12： | 1 |
| 9 | The importance of circadian rhythms on drug response in hypertension and coronary heart disease--from mice and man显示文摘 | Lemmer B | 2006 | Pharmacol Ther2006，111，3： | 1 |
| 10 | Discoveries of rhythms in human biological functions: a historical review显示文摘 | Lemmer B | 2009 | Chronobiollnt2009，26，6： | 1 |
| 11 | A short account of metastatic bone disease显示文摘 | Feller L Kramer B Lemmer J | 2011 | Cancer Cell Int2011，11，5： | 1 |
| 12 | Circadian changes in estimated hepatic blood flow in healthy subject显示文摘 | Lemmer B Nold G | 1991 | Br J Clin Pharmacol1991，32，： | 1 |
| 13 | chronopharmacological aspects for the prevention of acute coro- nary syndromes 显示文摘 | Lemmer B | 1998 | Eur Heart J1998，19，： | 1 |
| 14 | The importance of circadian rhythms on drug response in hypertension and coronary heart disease-from mice and man显示文摘 | Lemmer B | 2006 | Pharmacol Ther2006，111，3： | 1 |
| 15 | Safety and efficacy of strength training in patients with sporadic inclusion body myositis显示文摘 | Spector S A Lemmer J T Koffman B M | 1997 | Muscle Nerve1997，20，10： | 1 |
| 16 | Rhythms in second messenger mechanisms显示文摘 | Witte K Lemmer B | 2001 | Phar- macol Ther2001，51，2： | 1 |
| 17 | Circadian rhythms and drug delivery 显示文摘 | Lemmer B | 1991 | J Controlled Release1991，16，12： | 1 |
| 18 | Chronopharmacology--importance of the biological clock in drug treatment显示文摘 | Lemmer B | 2009 | Medizinische Monatsschrift für Pharmazeuten2009，，： | 1 |
| 19 | Circadian changes in estimated hepatic blood flow in healthy subject显示文摘 | Nold G | 1991 | Br J Clin Pharmacol1991，32，： | 1 |
| 20 | Circadian changes in estimated hepatic blood flow in healthy subjects 显示文摘 | Lemmer B Nold G | 2004 | Br J Clin Pharmacol2004，32，5： | 1 |
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