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| 1 | 从远志中分离鉴定出1种多巴胺受体活性化合物显示文摘目的从中药远志中提取脑内多巴胺(DA)受体活性化合物。方法用体外的放射配体-受体结合和高压液相法提取、分离、纯化DA受体活性化合物,用核磁共振和质谱仪确定活性化合物的结构。结果提取、分离到1种四氢非洲防己胺的活性化合物。其在体外可抑制3H-SCH23390(DA1受体亚型)和3H-螺呱隆(DA2受体亚型)与大鼠纹状体细胞膜的结合,其IC50值分别为(0.75±0.08)μmol/L和(0.92±0.10)μmol/L。这种活性化合物还能抑制3H-呱唑嗪和大鼠大脑膜α1-肾上腺素受体的结合(IC50值为46μmol/L),但是不能改变3H-QNB及3H-muscimol对膜的结合。Scatchardplot分析显示此化合物对3H-SCH23390和3H-螺呱隆与纹状体细胞膜的结合的抑制作用是通过竞争性与非竞争性混合机制而实现的。结论远志中提取到的四氢非洲防己胺是脑内多巴胺受体的活性化合物,它的抑制作用是通过竞争性与非竞争性混合机制而实现的。 | 沈行良 Witt MR Dekermendjian K Nielsen M | 2004 | 海南医学院学报2004，10，3： | 7 |
| 2 | Circadian rhythms in renal function in hypertensive TGR (mRen-2)27 rats and their nnrmotentive controls显示文摘 | Pons M Schnecko A Witte K | 1996 | Am J physio1996，271，： | 2 |
| 3 | Recent applications of protein arrays in target identification and disease monitoring 显示文摘 | WITTE K L NOCK S | 2004 | Drug Discovery Today: Technologies2004，1，： | 1 |
| 4 | Chronic alcoholism causes deleterious conditioning of innate immnnity显示文摘 | Frank J Witte K Schrodl W | 2004 | Alcohol Alcohol2004，9，35： | 1 |
| 5 | IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis 显示文摘 | Wolk K Witte E Wallace E | 2008 | Eur J Immunol2008，36，5： | 1 |
| 6 | Interleukin (IL) -19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs 显示文摘 | Kunz S W olk K Witte E et at | 2006 | Exp Dennatol2006，5，12： | 1 |
| 7 | Biopsies of olfactory epithelium in patients with Parkinson's disease显示文摘 | Witt M Bormann K Gudziol V | | 0，，06： | 1 |
| 8 | A meta-analysis of fear appeals- implications for effective public health campaigns 显示文摘 | WITTE K ALLEN M | 2000 | Health Education & Behavior2000，27，5： | 1 |
| 9 | Economies of scope in research and teaching: a non-parametric investigation显示文摘 | Witte K D Rogge N Cherchye L | 2012 | Omega2012，41，2： | 1 |
| 10 | A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infeetion显示文摘 | SCHOTT E WITT H NEUMANN K | 2007 | Journal of Hepatology2007，47，2： | 1 |
| 11 | Geometric relations between scales of small colour differences显示文摘 | K Witt | 1999 | Color Research Application1999，24，2： | 1 |
| 12 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 13 | Contribution of the nitric oxide-guanylyl cyclase system to circadian regulation of blood pressure in normotensive Wistar-Kyoto rats 显示文摘 | Schnecko A Zuther P | 1995 | Cardiovasc Res1995，30，5： | 1 |
| 14 | The prevalence of heart failure and asymptomatic left ventricular systolic dysfunction in a typical regional pacemaker population显示文摘 | Thackray S D Witte K K Nikitin N P | 2003 | Eur Heart J2003，24，12： | 1 |
| 15 | IL - 22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes : a potential role in psoriasis 显示文摘 | Wolk K Witte E Wallace E | 2006 | Eur J Immunol2006，36，5： | 1 |
| 16 | Identification of a rhabdomyosarco-ma targeting peptide by phage display with sequence similarities tothe tumour lymphatic-homing peptide Lyp-1 显示文摘 | Witt H Hajdin K Iljin K | 2009 | Int J Cancer2009，124，9： | 1 |
| 17 | Job Insecurity,Union Support and Intentions to Resign Membership:A Psychological Contract Perspective显示文摘 | De Witte H Sverke M Van Ruysseveldt J Goslinga S Chirumbolo A Hellgren J Naswall K | | 0，，1： | 1 |
| 18 | Picralide A:an unusual sosquit- erpene from Acrop6lon repens显示文摘 | Stevens K L Witt S C IGnt S | 1991 | Journal of Natural Products1991，54，1： | 1 |
| 19 | Structure function relationships in the lymphatic stystem and implications for cancer biology显示文摘 | Witte MH Jones K Wilting J | 2006 | Cancer Metastasis Rev2006，25，2： | 1 |
| 20 | IL-22 induces lipopolysaccharidebinding protein in hepatocytes: a potential systemic role of IL-22 in Crohn' s disease显示文摘 | Wolk K Witte E Hoffmann U | 2007 | J Immunol2007，178，9： | 1 |
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